HISTOMORPHOMETRIC ANALYSIS IN KIDNEY TISSUE OF MICE TREATED WITH INDIGOFERA SUFFRUTICOSA MILL

  • Marllon Alex Nascimento Santana Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE, Brazil
  • Ivanise Brito Da Silva Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE
  • JESSICA ANDREIA PEREIRA BARBOSA Department of Antibiotics/Universidade Federal de Pernambuco, Recife-PE, Brazil
  • Izabela Rangel Lima Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE
  • Jeymesson Raphael Cardoso Vieira Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE
  • Roberta Maria Pereira Leite Lima Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE, Brazil
  • SONIA PEREIRA LEITE Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE, Brazil

Abstract

Objective: To investigate by histomorphometry the effect of aqueous extract of Indigofera suffruticosa leaves on proximal convoluted tubules and renal corpuscles of mice with sarcoma 180.

Methods: Male swiss albino mice (Mus musculus) with 60 days of age were divided into 3 groups of 6 animals: Group 1-sarcoma 180 treated with aqueous extract (50 mg/kg, intraperitoneally (i. p.)), Group 2-sarcoma 180 treated with saline solution (15 ml/kg, i. p.) and Group 3–without sarcoma 180 treated with saline (15 ml/kg, i. p.). After 48 hours of tumor implantation, the treatment was initiated during 7 days. Histomorphometric analysis of kidney tissue was performed using IMAGEJ software.

Results: Antitumoral treatment with aqueous extract of I. suffruticosa leaves at a dose of 50 mg/kg has not caused mice renal tissue histological changes.

Conclusion: After treatment with aqueous extract of leaves of I. suffruticosa, renal architecture was preserved, suggesting its safety use as an antitumor agent.

 

Keywords: Histomorphometry, Indigofera suffruticosa, Kidney, Sarcoma 180

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Author Biographies

Marllon Alex Nascimento Santana, Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE, Brazil
Department of Histology and Embriology
Ivanise Brito Da Silva, Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE
Department of Histology and Embriology
JESSICA ANDREIA PEREIRA BARBOSA, Department of Antibiotics/Universidade Federal de Pernambuco, Recife-PE, Brazil

Department of Antibiotics

Izabela Rangel Lima, Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE
Department of Histology and Embriology
Jeymesson Raphael Cardoso Vieira, Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE
Department of Histology and Embriology
Roberta Maria Pereira Leite Lima, Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE, Brazil
Department of Histology and Embriology
SONIA PEREIRA LEITE, Department of Embryology and Histology/Universidade Federal de Pernambuco, Recife-PE, Brazil

Department of Histology and Embriology

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How to Cite
Santana, M. A. N., I. B. D. Silva, J. A. P. BARBOSA, I. R. Lima, J. R. C. Vieira, R. M. P. Leite Lima, and S. P. LEITE. “HISTOMORPHOMETRIC ANALYSIS IN KIDNEY TISSUE OF MICE TREATED WITH INDIGOFERA SUFFRUTICOSA MILL”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 9, July 2015, pp. 505-6, https://innovareacademics.in/journals/index.php/ijpps/article/view/7004.
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