BARLERIA MONTANA WIGHT AND NEES–A PROMISING NATURAL ANTI-INFLAMMATORY AGENT AGAINST FORMALIN INDUCED INFLAMMATION

  • Sriram Sridharan Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur 613401, Tamil Nadu
  • Meenaa Venkatramani SASTRA University
  • Kavitha Janakiraman SASTRA University
  • Brindha Pemiah SASTRA University
  • Sasikumar Chinnagounder SASTRA University

Abstract

Objective: To evaluate the anti-inflammatory activity of the ethanolic leaf extract of Barleria montana (B. montana) against formalin induced inflammation.

Methods: Male albino wistar rats were pretreated with oral doses of 100 mg, 200 mg and 300 mg of the extract for 30 days and the animals received a single dose of sub plantar injection of formalin (0.1 ml/kg body weight (bw.)) Indomethacin (25 mg/kg bw.) was used as the standard drug. The effect of the extract on paw thickness, biochemical and hematological parameters was investigated along with histopathological studies.

Results: The results revealed that the extract exhibited an effective dose dependent activity against formalin induced inflammation with a maximum activity at a dosage of 300 mg/kg bw. which was comparable with the standard drug.

Conclusion: The results signify promising activity of ethanolic leaf extract of B. montana against formalin induced inflammation in albino rats. The extract was also found to exhibit appreciable antioxidant activity.

 

Keywords: Barleria montana, Formalin, Inflammation, Indomethacin

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How to Cite
Sridharan, S., M. Venkatramani, K. Janakiraman, B. Pemiah, and S. Chinnagounder. “BARLERIA MONTANA WIGHT AND NEES–A PROMISING NATURAL ANTI-INFLAMMATORY AGENT AGAINST FORMALIN INDUCED INFLAMMATION”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 9, July 2015, pp. 80-84, https://innovareacademics.in/journals/index.php/ijpps/article/view/7009.
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