SYNTHESIS AND EVALUATION OF ZINC SUBSTITUTED MAGNETITE NANOPARTICLES FOR DRUG DELIVERY SYSTEMS


Iryna Vedernikova

Abstract


Objective: The aim of this study is to synthesis zinc substituted magnetite nanoparticles with higher values of saturation magnetization and testing its antibacterial activity.

Methods: The particles of zinc substituted magnetite with the composition ofZnxFe3-xO4 (х = 0.0, 0.2, 0.3, 0.4, 0.5) were prepared using a chemical condensation method. The crystalline structure, morphology and the magnetic properties of the ferrite particles were studied by means of X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer. The synthesized ZnMNPs40 were tested for their antibacterial and antifungal activity by disc diffusion method.

Results: X-ray diffraction analysis showed that the nanoparticles formed in the present synthesis were crystalline (spinel type) in nature. The size of the synthesized nanoparticles was in the range of 3-13 nm obtained from TEM image. Magnetic measurements at 300 Кhavede monstrated the super paramagnetic behavior of the nanoparticles. The synthesized ZnMNPs40 nanoparticles exhibited antibacterial activity against bacterial strains like Bacillus subtilis, Escherichia coli, Staphylococcus aureus and antifungal activity.

Conclusion: Zinc has been incorporated into the crystal structure of magnetite to enhance the saturation magnetization of nanoparticles. The synthesized ZnMNPs had a nanometric size and a superparamagnetic behavior, exhibited effective antibacterial property.

 


Keywords


Ferrite nanoparticles, Composition, Structure, Magnetization, Antibacterial activity

| PDF | HTML |

References


Mudshinge SR, Deore AB, Patil S, Bhalgat CM. Nanoparticles: emerging carriers for drug delivery. Saudi Pharm J 2011;19:129-41.

Krishnan K. Biomedical nanomagnetics: a spin through possibilities in imaging, diagnostics, and therapy. IEEE Trans Magn 2010;46:2523-58.

Tartaj P, Morales M, Veintemillas-Verdaguer S, Gonz´alez T, Serna C. The preparation of magnetic nanoparticles for applications in biomedicine. J Phys D: Appl Phys 2003;36:182-97.

Faraji M, Yamini Y, Rezaee M. Magnetic nanoparticles: synthesis, stabilization, functionalization, characterization, and applications. J Iran Chem Soc 2010;7:1-37.

Indira TK, Lakshmi MK. Magnetic nanoparticles–a review. Int J Pharm Sci Nanotechnol 2010;3:1035-42.

Sangeetha N, Kumaraguru AK. Antitumor effects and characterization of biosynthesized iron oxide nanoparticles using seaweeds of Gulf of Mannar. Int J Pharm Pharm Sci 2015;7:469-76.

Koppisetti V, Sahiti B. Magnetically modulated drug delivery systems. Int J Drug Dev Res 2011;3:260-6.

Saiyed Z, Telang S, Ramchand C. Application of magnetic techniques in the fields of drug discovery and biomedicine. BioMagnetic Res Technol 2003;1:1-13.

Girgis E, Wahsh M, Othman A, Bandhu L, Rao KV. Synthesis, magnetic and optical properties of core/shell Co1-x ZnxFe2O4/SiO2 nanoparticles. Nanoscale Res Lett 2011;6:1-12.

Kharkwal R, Uma S, Nagarajan R. Synthesis and optical properties of pure CdTiO3 and Ni2+and Zn2+ion substituted CdTiO3 obtained by a novel precursor route. Indian J Chem 2012;51A:1538-44.

Krishna RK, Ravinder D, Kumar K. Thermo electrical power studies of nickel-zinc ferrites synthesized by citrate gel technique. Int J Eng Res Ind Appl 2013;3:1459-68.

Chu A, Foster M, Hancock D, Bell-Anderson K, Petocz P, Samman S. TNF-a gene expression is increased following zinc supplementation in type 2 diabetes mellitus. Genes Nutr 2015;10:1-10.

Miceli MV, Tatejr DJ, Alcock NW, Newsome DA. Zinc deficiency and oxidative stressin the retina of pigmented rats. Invest Ophthalmol Visual Sci 1999;40:1238-44.

Harréus U, Baumeister P, Zieger S, Matthias C. The influence of high doses of vitamin C and zinc on oxidative DNA damage. Anticancer Res 2005;25:3197–202.

Osredkar J, Sustar N. Copper and zinc, biological role and significance of copper/zinc imbalance. J Clin Toxicol 2011;3:2-18.

Prasad AS. Zinc: role in immunity, oxidative stress and chronic inflammation. Curr Opin Clin Nutr Metab Care 2010;12:646-52.

Baskar G, Chandhuru J, Fahad S, Praveen A. Mycological synthesis, characterization and antifungal activity of zinc oxide nanoparticles. Asian J Pharm Technol 2013;3:142-6.

Xie Y, He Y, Irwin P, Jin T, Shi X. Antibacterial activity and mechanism of action of zinc oxide nanoparticles against Campylobacter jejuni. Appl Environ Microbiol 2011;77:2325-31.

Zhang LL, Jiang YH, Ding YL, Povey M, York D. Investigation into the antibacterial behaviour of suspensions of ZnO nanoparticles (ZnO nanofluids). J Nanopart Res 2007;9:479-89.

Azam A, Ahmed A, Oves M, Khan M, Habib S, Memic A. Antimicrobial activity of metal oxide nanoparticles against Gram-positive and Gram-negative bacteria: a comparative study. Int J Nanomed 2012;7:6003-9.

Gordon T, Perlstein B, Houbara O, Felner I, Banin E, Margel S. Synthesis and characterization of zinc/iron oxide composite nanoparticles and their antibacterial properties. Colloids Surf A 2001;374:1-8.

Mathew DS, Juang RS. An overview of the structure and magnetism of spinel ferrite nanoparticles and their synthesis in microemulsions. Chem Eng J 2007;129:51-65.

Kumar L, Kumar P, Narayan A, Kar M. Rietveld analysis of XRD patterns of different sizes of nanocrystalline cobalt ferrite. Int Nano Lett 2013;3:26-34.

Singhal S, Namgyal T, Bansal S, Chandra K. Effect of Zn substitution of the magnetic properties of cobalt ferrite nanoparticles prepared via sol-gel route. J Electromagn Anal Appl 2010;2:376-81.

Mahdavi M, Ahmad MB, Haron M, Namvar F, Nadi B, Zaki M, et al. Synthesis, surface modification and characterisation of biocompatible magnetic iron oxide nanoparticles for biomedical applications. Molecules 2013;18:7533-48.

Navale GR, Thripuranthaka M, Late DJ, Shinde SS. Antimicrobial activity of ZnO nanoparticles against pathogenic bacteria and fungi. J Sci Med Nanotechnol Nanomed 2015;3:2-9.

Atmaca S, Gul K, Cicek R. The effect of zinc on microbial growth. Turk J Med Sci 1998;28:595-7.

Goudouri O, Kontonasaki E, Lohbauer U, Boccaccini A. Antibacterial properties of metal and metalloid ions in chronic periodontitis and peri-implantitis therapy. Acta Biomater 2014;10:3795–810.

Chandrika R, Mayi P, Kumar R. Role of ZnO nanoparticles in enhancing the antibacterial activity of antibiotics. Asian J Pharm Clin Res 2012;5:97-9.




About this article

Title

SYNTHESIS AND EVALUATION OF ZINC SUBSTITUTED MAGNETITE NANOPARTICLES FOR DRUG DELIVERY SYSTEMS

Keywords

Ferrite nanoparticles, Composition, Structure, Magnetization, Antibacterial activity

Date

11-07-2015

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 7, Issue 9, 2015 Page: 177-180

Online ISSN

0975-1491

Authors & Affiliations

Iryna Vedernikova
Department of Inorganic Chemistry, National University of Pharmacy, Pushkinskaya St. 53, 61002 Kharkov, Ukraine
Ukraine


Article Tools



Refbacks

  • There are currently no refbacks.