ANTIDIABETIC ACTIVITY OF CLERODENDRUM PHILIPPINUM SCHAUER LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

  • Mihir K. Kar University Department of Pharmaceutical Sciences (UDPS), Utkal University, Vani Vihar, Bhubaneswar 751004
  • Trupti R. Swain S. C. B. Medical College
  • Sagar K. Mishra Utkal University

Abstract

Objective: The present study has been undertaken to evaluate the antidiabetic activity of Clerodendrum philippinum Schauer leaves.

Methods: The fresh leaves were collected from Kuruan village of Jajpur district in the state of Odisha, India and extracted successively with n-hexane, methanol and water. The effect of extracts at the dose level of 400 mg/kg body weight was studied in normal, glucose loaded and streptozotocin-induced diabetic rats.

Results: The test extracts showed significant reduction of blood glucose level in normal, glucose loaded and streptozotocin-induced diabetic rats. Methanol extract demonstrated maximum blood glucose lowering potential as compared to other extracts.

Conclusion: The leaf of Clerodendrum philippinum Schauer is endowed with blood sugar lowering potential in both normal and diabetic rats.

 

Keywords: Clerodendrum philippinum Schauer, Antidiabetic activity, Streptozotocin

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How to Cite
Kar, M. K., T. R. Swain, and S. K. Mishra. “ANTIDIABETIC ACTIVITY OF CLERODENDRUM PHILIPPINUM SCHAUER LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 9, July 2015, pp. 386-9, https://innovareacademics.in/journals/index.php/ijpps/article/view/7428.
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