• Sadagopan Sekar University of Mysore
  • Nagaraja Naik Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006
  • Sridhara Ajjanna Mahalingappa. University of Mysore
  • Peethamber S. K. University of Mysore


Objective: Synthesis, characterization and biological screening of some new 1,6-disubstituted Octahydro-1H-pyrrolo[3,4-b]pyridine Schiff base (13a-n) derivatives.

Methods: The scaffold of Octahydro-1H-pyrrolo [3,4-b]pyridine Schiff bases was prepared, synthesised and screened for their biological activity.

Results: The structure of newly synthesized compounds was characterized by spectral data and screened for their biological activity like antioxidant, antimicrobial, antifungal, and chelating efficacy activities against various bacteria and fungi strains. Screening revealed that several of these compounds (13a-n) showed potential biological activity.

Conclusion: Investigation on newly synthesised 1,6-disubstituted Octahydro-1H-pyrrolo[3,4-b]pyridine Schiff base (13a-n) derivatives for their biological activity revealed that some of the compounds showed good antioxidant, chelating and antimicrobial properties. The fact that the newly synthesised Schiff bases in this study are chemically related to the current medication and suggests further work is clearly warranted and to be explored.


Keywords: Octahydro-1h-pyrrolo [3, 4-b]pyridine, Schiff base, Moxifloxacin, 8-methoxy fluoroquinolone, DPPH, antioxidants


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How to Cite
Sekar, S., N. Naik, S. A. Mahalingappa., and P. S. K. “SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF CERTAIN SCHIFF BASES OF OCTAHYDRO-1H-PYRROLO [3, 4-B] PYRIDINE DERIVATIVES”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 9, July 2015, pp. 412-9,
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