A RETROSPECTIVE STUDY OF CLINICAL PROFILE AND DRUG PRESCRIBING PATTERN IN OSTEOPOROSIS IN A TERTIARY CARE HOSPITAL


Amruta Tripathy, Shalini Adiga, Hitesh Hasmukhlal Shah, Tara Shanbhag, Mahesh Kumar D

Abstract


Objective: To study the clinical profile and prescription pattern of drugs in the treatment of osteoporosis in a tertiary care centre in Karnataka, India.

Methods: This was a retrospective study carried out in a multi-speciality tertiary care hospital in Karnataka. Information was collected from case record forms of 100 patients of osteoporosis during a 12 mo tenure regarding various signs and symptoms they presented with and treatment provided.

Results: Majority of the subjects were females (90%). Low back ache was the most common presenting symptom. There was an increase in mean calcium (8.84±8.32 mg/dL) and phosphorus levels (2.45±1.83 mg/dL) as compared to baseline at the follow up visit. Vitamin D and calcium supplementation were the most commonly prescribed medications followed by analgesics, calcitonin and bisphosphonates. A total of 77 adverse reactions were reported, gastritis being the commonest one.

Conclusion: Vitamin D and Calcium supplements were more commonly prescribed than specific anti osteoporotic medications.

 


Keywords


Low back ache, Bisphosphonates, vitamin D, Calcium, Prescribing trends

| PDF | HTML |

References


Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. WHO Tech Rep Ser 1994;843:1-129.

India. Available from: URL: http://www.iofbonehealth. org/sites/default/files/PDFs/Audit%20Asia/Asian_regional_audit_India.pdf. [Last accessed on 27 Aug 2014]

The Asia-Pacific Regional Audit. Epidemiology, costs and burden of osteoporosis in; 2013. Available from: URL: http://www.iofbonehealth.org/sites/default/files/media/PDFs/Regional%20Audits/2013-Asia_Pacific_Audit_0_0.pdf. [Last accessed on 27 Aug 2014]

Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 2005;115:3318–25.

Das S, Crockett JC. Osteoporosis–a current view of pharmacological prevention and treatment. Drug Des Dev Ther 2013:7;435–48.

Lo CW, Paris PW, Holick MF. Indian and Pakistani immigrants have the same capacity as Caucasians to produce vitamin D in response to ultraviolet irradiation. Am J Clin Nutr 1986;44:683-5.

Osteoporosis factsheet. Available from: URL: https://dolcera.com/wiki/images/Osteoporosis_factsheet. pdf. [Last accessed on 27 Aug 2014]

Sankaran B. Clinical studies: Incidence of fracture neck of femur and intertrochanteric fractures in three Delhi hospitals. In: Sankaran B. editor. Osteoporosis. New Delhi: South East Asia Regional Office, World Health Organisation; 2000. p. 9-18.

Pasco J, Henry M, Korn S, Nicholson G, Kotowicz M. Morphometric vertebral fractures of the lower thoracic and lumbar spine, physical function and quality of life in men. Osteoporosis Int 2009;20:787-92.

Malhotra N, Mithal A. Osteoporosis in Indians. Indian J Med Res 2008;127:263-8.

Kumar KHS, Bhaskar P. Osteoporosis-an emerging disease of the 21 century, part 1:an overview. J Family Med Primary Care 2012;1:66–8.

Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D. Vitamin D status in Andhra Pradesh: a population based study. Indian J Med Res 2008;127:211-8.

Ho-Pham LT, Nguyen ND, Vu BQ, Pham HN, Nguyen TV. Prevalence and risk factors of radiographic vertebral fracture in postmenopausal Vietnamese women. Bone 2009;45:213-7.

Clark P, Cons-Molina F, Deleze M, Talavera J, Palermo L, Cummings S. The prevalence of radiographic vertebral fractures in Mexican men. Osteoporosis Int 2010;21:1523-8.

Kumar V, Abbas AK, Aster JC. editors. Robbins Basic Pathology. 9th ed. Philadelphia: Elsevier Saunders; 2013. p. 765-71.

Varenna M, Manara M, Galli L, Binelli L, Zucchi F, Sinigaglia L. The association between osteoporosis and hypertension: The role of a low dairy intake. Calcif Tissue Int 2013;93:86–92.

Saigal R, Mathur V, Prashant RK, Mittal V. Glucocorticoid induced osteoporosis. Indian J Rheumatol 2006;1:20-6.

Canalis E, Giustina A, Bilezikian JP. Mechanisms of anabolic therapies for osteoporosis. N Engl J Med 2007;357:905-16.

Roux C, Briot K, Gossec L, Kolta S, Blenk T, Felsenberg D, et al. Increase in vertebral fracture risk in postmenopausal women using omeprazole. Calcif Tissue Int 2009;84:13-9.

Papadimitropoulos E, Wells G, Shea B, Gillespie W, Weaver B, Zytaruk N, et al. Meta-analyses of therapies for postmenopausal osteoporosis. VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women. Endocr Rev 2002;23:560–9.

Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 y and older: a meta-analysis. Lancet 2007;370:657–66.

Wysowki DK, Greene P. Trends in osteoporosis treatment with oral and intravenous bisphosphonates in the United States, 2002-2012. Bone 2013;57:423-8.

Blau LA, Hoehns JD. Analgesic efficacy of calcitonin for vertebral fracture pain. Ann Pharmacother 2003;37:564-70.

van den Bergh JPW, Bouts ME, van der Veer E, van der Velde RY, Janssen MJW, Geusens PP, et al. Comparing tolerability and efficacy of generic versus brand alendronate: A randomized clinical study in postmenopausal women with a recent fracture. Plos One 2013; doi: 10.1371/journal.pone.0078153. [Article in Press].




About this article

Title

A RETROSPECTIVE STUDY OF CLINICAL PROFILE AND DRUG PRESCRIBING PATTERN IN OSTEOPOROSIS IN A TERTIARY CARE HOSPITAL

Keywords

Low back ache, Bisphosphonates, vitamin D, Calcium, Prescribing trends

Date

02-09-2015

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 7, Issue 10, 2015 Page: 390-393

Online ISSN

0975-1491

Statistics

153 Views | 63 Downloads

Authors & Affiliations

Amruta Tripathy
Department of Pharmacology Kasturba Medical College, Manipal University
India

Shalini Adiga
Kasturba Medical College, Manipal University
India

Hitesh Hasmukhlal Shah
Kasturba Medical College, Manipal University
India

Tara Shanbhag
Srinivas Institute of Medical Sciences and Research Centre, Surathkal
India

Mahesh Kumar D
Kasturba Medical College, Manipal University
India


Article Tools



Refbacks

  • There are currently no refbacks.