FORMULATION DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING TABLET OF CIPROFLOXACIN HYDROCHORIDE

  • Maulesh M. Chokshi
  • Madan Mohan Gupta School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago, WI
  • Madhulika Gupta

Abstract

Objective: The aim of formulating floating tablets of ciprofloxacin hydrochloride was to prolong the gastric residence time after oral administration to achieve the controlled release of drug. Ciprofloxacin hydrochloride, a broad-spectrum fluoroquinolone antibacterial agent and it is use in the treatment of bone and joint infections, diarrhoeal infection, lower respiratory tract infections, urinary tract infections and meningococcal prophylaxis.

Methods: Floating tablets of Ciprofloxacin hydrochloride were prepared by wet granulation method using two different grades (K-100M & K-4M) of Hydroxyl Propyl Methyl Cellulose (HPMC) and Carbopol 934P using effervescent technique. Sodium bicarbonate was incorporated as a gas-generating agent. The floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy and dissolution studies. The effect of citric acid on drug release profile and floating properties was also investigated.

Results: It was observed that tablet swelled radially and axially during in vitro buoyancy studies and remained buoyant for 10-14 h. The combination of sodium bicarbonate (70 mg) and citric acid (20 mg) was found to achieve the optimum in vitro buoyancy.

Conclusion: In the present work it was concluded that the floating duration of was more in tablet with HPMC K-100 as compared with formulations containing HPMC K-4M. Drug ciprofloxacin hydrochloride release could be prolonged about 14 h in the GIT by using blend of HPMC-K 100M with sodium bicarbonate as gas generating agent and formulate it as a gastro retentive floating tablet.

Keywords: Floating lag time, Ciprofloxacin hydrochloride, Total floating time, Hydroxyl Propyl Methyl Cellulose

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References

1. Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery system. Opin Drug Delivery 2006;3:217-33.
2. Gupta MM, Patel Vishal. Formulation and evaluation oral dispersible tablet of cinnarizine. J Drug Delivery Ther 2013;3:12-7.
3. Sungthongjeen S, Paeratakul O, Limmatvapirat S, Puttipupathachorn S. Preparation and in-vitro evaluation of multiple-unit floating drug delivery system based on gas formation technique. Int J Pharm 2006;324:136-43.
4. Krogel I, Bodmeier R. Development of a multifunctional matrix drug delivery system surrounded by an impermeable cylinder. J Controlled Release 1999;61:43-50.
5. Sean C Sweetman. Martindale the complete drug reference. 34th ed. Pharmaceutical Press; 2000. p. 188-9.
6. El-kamel AH, Sokar MS, Gamal SS. Preparation and evaluation of ketoprofen floating oral delivery system. Int J Pharm 2001;220:13–21.
7. Basak, SC, Rahman J, Ramalingam M. Design and in vitro testing of a floatable gastro retentive tablet of metformin hydrochloride. Pharmazie 2007;62:145-8.
8. Patel VF, Patel NM. Intragastric floating drug delivery system of cefuroxime axetil: in vitro evaluation. AAPS PharmSciTech 2006;7:118-24.
9. Brahma N Singh, Kwon H kim. Floating drug delivery system: an approach to oral controlled drug delivery via gastric retention. J Controlled Release 2000;3:235-59.
10. Dave BS, Amin AF, Patel MM. Gastroretentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation. AAPS PharmSciTech 2004;5:34-42.
11. Basak SC, Rao N. Development and in vitro evaluation of an oral floating matrix tablet formulation of ciprofloxacin. Indian J Pharm Sci 2004;66:313-6.
12. Ravindra J, Salunke Sadhana R, Shahi Sandeep C, Atram Gajendra B Neb. Formulation and evaluation of the hydrodynamically balanced system of ciprofloxacin HCl. Int J Pharm Res Dev 2009;7:15-20.
13. Rosa M, Zia H, Rhodes T. Dosing and testing in-vitro of a bioadhesive and floating drug delivery system for oral application. Int J Pharm 1994;105:65-70.
14. Babu VBM, Khar RK. In vitro and in vivo studies of sustained release floating dosage forms containing salbutamol sulphate. Pharmazie 1990;45:268-70.
15. Whitehead L, Fell JT, Collett JH, Sharma HL, Smith A. Floating dosage forms: an in vivo study demonstrating prolonged gastric retention. J Controlled Release 1998;55:3-12.
16. Gupta MM, Niraj, Chauhan BS, Pandey Shweta. Fast disintegrating combination tablet of taste masked levocetirizine dihydrochloride and monetilukast sodium: formulation design development and evaluation. J Pharm 2014. doi.org/10.1155/2014/568320. [Article in Press]
17. Vishal G, Karkhile Sontakke MA, Ritesh R Karmarkar, Barhate SD, Tupkari S. Formulation and evaluation of floating tablet of frusemide. Int J Pharm Res Dev 2010;1:15-7.
18. Harikumar SL, Mishra SB, Kdian SS. Formulation, and evaluation of floating tablets of celecoxib. Asian J Pharm 2009;2:56-9.
19. Devarajan K, Rangasamy M, Selvaraj J, Natesan SK. Development and evaluation of floating tablets of ciprofloxacin HCl. Int J Pharm Res Scholars 2012;1:17-25.
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How to Cite
Chokshi, M. M., M. M. Gupta, and M. Gupta. “FORMULATION DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING TABLET OF CIPROFLOXACIN HYDROCHORIDE”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 4, Apr. 2016, pp. 148-52, https://innovareacademics.in/journals/index.php/ijpps/article/view/8181.
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