ANTIMICROBIAL POTENTIAL OF STREPTOMYCES CHEONANENSIS VUK-A FROM MANGROVE ORIGIN

  • Krishna Naragani
  • Ushakiranmayi Mangamuri
  • Vijayalakshmi Muvva Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur 522510, Andhra Pradesh, India
  • Sudhakar Poda
  • Rajesh Kumar Munaganti

Abstract

Objectives: The aim of the present study was to isolate, characterize and evaluate the activity of compounds produced by Streptomyces cheonanensis VUK-A.

Methods: Chemical examination of the secondary metabolites of the strain Streptomyces cheonanensis VUK-A has led to the segregation of one bioactive compound (1) and a partially purified fraction (2). The strain was isolated from the sediment samples of mangrove ecosystem of Coringa, south coastal Andhra Pradesh, India. The chemical structure of the active compound 1 was established on the basis of spectroscopic analysis including 1H NMR, 13C NMR spectroscopy, FTIR and EIMS. The partially purified sub-fraction (2) subjected to Gas Chromatography-Mass spectroscopy. The antimicrobial activity of the bioactive compounds produced by the strain was expressed in terms of minimum inhibitory concentration.

Results: The compound 1 was isolated from the fermentation broth was characterized as benzoic acid (1) based on spectroscopic analysis. The partially purified sub-fraction (2) subjected to Gas Chromatography-Mass spectroscopy contained nine analogues: 1-tetradecene, tetradecane, 1-hexadecene, hexadecane, 5-octadecene, octadecane, 5-eicosene, 1-nonadecene and cyclo tetracosane. The compounds recorded moderate to significant antimicrobial activity against medicinally and agriculturally important bacteria and fungi. This is the first report of six partially purified compounds 1-tetradecene, tetradecane, hexadecane, octadecane, 5-eicosene and cyclo tetracosane from the genus Streptomyces.

Conclusion: The results of the present study showed that the metabolites of Streptomyces cheonanensis VUK-A exhibited antibacterial and antifungal activities. The study also supports that Coringa, a promising mangrove ecosystem remained to be explored for new bioactive compounds.

Keywords: Streptomyces cheonanensis, Mangrove Ecosystem, Natural Products, Antimicrobial activity.

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How to Cite
Naragani, K., U. Mangamuri, V. Muvva, S. Poda, and R. K. Munaganti. “ANTIMICROBIAL POTENTIAL OF STREPTOMYCES CHEONANENSIS VUK-A FROM MANGROVE ORIGIN”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 3, Mar. 2016, pp. 53-57, https://innovareacademics.in/journals/index.php/ijpps/article/view/8234.
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