MYRISTICA FRAGRANS: A COMPREHENSIVE REVIEW

  • Tripathi Nagja Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat
  • Kumar Vimal Nirma University
  • Acharya Sanjeev Nirma University

Abstract

Myristica fragrans is a spreading tree, growing 9-12 m high, chiefly cultivated in Maluku region of Indonesia, known as the Spice Islands in earlier times. Caribbean islands of Grenada and Trinidad are also influential in growing this aromatic tree commercially. It belongs to Myristicaceae family and is the source of two spices, nutmeg (Jaiphal) and mace (Javitri). Nutmeg is the seed kernel inside the fruit and mace is the fleshy red, net-like skin covering (aril) on the kernel. Further, studies divulge the occurrence of different chemical constituents like Myristicin, Macelignan and Eugenol (4-allyl-2-methoxyphenol). Nutmeg possesses various pharmacological activities like hepato protective activity, anti-oxidant activity, memory enhancing activity, cytotoxicity, aphrodisiac activity, anti-diabetic activity, anti-depressant activity, hypolipidemic and hypocholesterolemic effect, anti-microbial activity, antibacterial, anti-inflammatory, anti-carcinogenic activity, flavouring properties and pesticidal activity. This article reviews various pharmacological properties of this medicinal plant.

 

Keywords: Myristica fragrans, Nutmeg, Myristicin

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References

1. Anonymous. Wealth of India: Raw materials. Vol. VI. Council of Scientific and Industrial Research, New Delhi; 1962. p. 474-6.
2. Peter KV. Handbook of herbs and spices. Vol. 2. Woodhead Publishing Ltd., Cambridge; 2001. p. 238-48.
3. Rosengarten F Jr. The book of spices. 1st ed. Livingston Publishing Company; 1969. p. 489.
4. Shinohara C, Mori S, Ando T, Tsuji T. Arg-gingipain inhibition and anti-bacterial activity selective for Porphyromonas gingivalis by malabaricone C. Biosci Biotechnol Biochem 1999;63:1475-7.
5. Smith-Palmer A, Stewart J, Fyfe L. Inhibition of listeriolysin O and phosphatidylcholine-specific production in Listeria monocytogenes by subinhibitory concentrations of plant essential oils. J Med Microbiol 2002;51:567-74.
6. Van Gils C, Cox PA. Ethnobotany of nutmeg in the spice islands. J Ethnopharmacol 1994;42:117-24.
7. Kalbhen DA. Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans). Angew Chem Int Ed Engl 1971;10:370-4.
8. Smith AC. The american species of the myristicaceae. Brittonia 1937;2:393-510.
9. Armstrong JE. Pollination by deceit in nutmeg (Myristica insipida, Myristicaceae): floral displays and beetle activity at male and female trees. Am J Bot 1997;84:1266-74.
10. Wilde WJJO. The genera of myristicaceae as distinguished by their inflorescences, and the description of a new genus. Bicuiba Beitr Biol Pflanzen 1991;66:95-125.
11. Burkill IH, Birtwistle W, Foxworthy FW, Scrivenor JB, Watson JG. A dictionary of the economic products of the malay peninsula. 2nd Ed. Vol. 1. Crown Agents, London; 1966. p. 1554-6.
12. Qiu Q, Zhang G, Sun X, Liu X. Study on chemical constituents of the essential oil from Myristica fragrans Houtt. by supercritical fluid extraction and steam distillation. Zhongyaocai 2004;27:823-6.
13. Yang XW, Huang X, Ahmat M. New neolignan from the seed of Myristica fragrans. Zhongguo Zhongyao Zazhi 2008;33:397-402.
14. Jaiswal P, Kumar P, Singh VK, Singh DK. Biological effects of Myristica fragrans. Annu Rev Biomed Sci 2009;11:21-9.
15. Sonavane GS, Sarveiya VP, Kasture VS, Kasture SB. Anxiogenic activity of Myristica fragrans seeds. Pharmacol Biochem Behav 2002;71:239-44.
16. Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of volatile plant oils. J Appl Microbiol 2000;88:308-16.
17. Valero M, Salmerón MC. Antibacterial activity of 11 essential oils against Bacillus cereus in tantalized carrot broth. Int J Food Microbiol 2003;85:73-81.
18. Orabi KY, Mossa JS, el-Feraly FS. Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans). J Nat Prod 1991;54:856-9.
19. De M, De AK, Banerjee AB. Antimicrobial screening of some Indian spices. Phytother Res 1999;13:616-8.
20. Zaleha S, Shuhairi NN, Yap NMF, Sibungkil CAH, Latip J. Antibacterial activity of Myristica fragrans against oral pathogens. J Evidence-Based Complementary Altern Med 2012;1-7. doi.org/10.1155/2012/825362. [Article in Press]
21. Radwan MM, Tabanca N, Wedge D, Tarawneh AH, Cutler SJ. Antifungal compounds from turmeric and nutmeg with activity against plant pathogens. Fitoterapia 2014;99:341-6.
22. Somani RS, Singhai AK. Hypoglycemic and antidiabetic activities of seeds of Myristica fragrans in normoglycemic and alloxan-induced diabetic rats. Asian J Exp Sci 2008;22:95-102.
23. Lestari K, Hwang JK, Kariadi SH, Wijaya A, Ahmad T, Subarnas A, et al. Screening for PPAR γ agonist from Myristica fragrans Houtt seeds for the treatment of Type 2 diabetes by in vitro and in vivo. Med Heal Sci J 2012;12:7-15.
24. Ram A, Lauria P, Gupta R, Sharma VN. Hypolipidaemic effect of Myristica fragrans fruit extract in rabbits. J Ethnopharmacol 1996;55:49-53.
25. Sharma A, Mathur R, Dixit VP. Prevention of hypercholesterolemia and atherosclerosis in rabbits after supplementation of Myristica fragrans seed extract. Indian J Physiol Pharmacol 1995;39:407-10.
26. Morita T, Jinno K, Kawagishi H. Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/d-galactosamine-induced liver injury. J Agric Food Chem 2003;51:1560-5.
27. Singh A, Rao AR. Modulatory effect of areca nut on the action of mace (Myristica fragrans, Houtt) on the hepatic detoxification system in mice. Food Chem Toxicol 1993;31:517-21.
28. Sohn JH, Han KL, Kim JH, Rukayadi Y, Hwang JK. Protective effects of mace lignan on cisplatin-induced hepatotoxicity is associated with JNK activation. Biol Pharm Bull 2008;31:273-7.
29. Kareem MA, Gadhamsetty SK, Shaik AH, Prasad EM, Kodidhela LD. Protective effect of nutmeg aqueous extract against experimentally induced hepatotoxicity and oxidative stress. J Ayurveda Integrative Med 2013;4:216-23.
30. Ozaki Y, Soedigdo S, Wattimena YR, Suganda AG. Anti-inflammatory effect of mace, aril of Myristica fragrans Houtt., and its active principles. Jpn J Pharmacol 1989;49:155-63.
31. Lee JY, Park W. Anti-inflammatory effect of myristicin on RAW 264.7 macrophages stimulated with polyinosinic-polycytidylic acid. Molecules 2011;16:7132-42.
32. Tezuka Y, Irikawa S, Kaneko T. Screening of Chinese herbal drug extracts for inhibitory activity on nitric oxide production and identification of an active compound of Zanthoxylum bungeanum. J Ethnopharmacol 2001;77:209-17.
33. Dewi K, Widyarto B, Erawijantari PP, Widowati W. In vitro study of Myristica fragrans seed (Nutmeg) ethanolic extract and quercetin compound as an anti-inflammatory agent. Int J Res Med Sci 2015;3:2303-10.
34. Helen PM. Phytochemical analysis and anticancer activity of essential oil from Myristica fragrans. Int J Curr Pharm 2012;2:188-98.
35. Piras A, Rosa A, Marongiu B. Extraction and separation of volatile and fixed oils from seeds of Myristica fragrans by supercritical COâ‚‚: chemical composition and cytotoxic activity on Caco-2 cancer cells. J Food Sci 2012;77:448-53.
36. Chirathaworn C, Kongcharoensuntorn W, Dechdoungchan T, Lowanitchapat A, Sa-nguanmoo P, Poovorawan Y. Myristica fragrans houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation. J Med Assoc Thai 2007;90:2422-8.
37. Ejechi BO, Souzey JA, Akpomedaye DE. Microbial stability of mango (Mangifera indica L.) juice preserved by combined application of mild heat and extracts of two tropical spices. J Food Prot 1998;61:725-7.
38. Jannu LN, Hussain SP, Rao AR. Chemopreventive action of mace (Myristica fragrans, Houtt) on DMBA-induced papilloma genesis in the skin of mice. Cancer Lett 1991;56:59-63.
39. Hussain SP, Rao AR. Chemopreventive action of mace (Myristica fragrans, Houtt) on methylcholanthrene-induced carcinogenesis in the uterine cervix in mice. Cancer Lett 1991;56:231-4.
40. Prakash E, Gupta DK. Cytotoxic activity of ethanolic extract of Myristica fragrans (Houtt) against seven human cancer cell lines. Universal J Food Nutrition Sci 2013;1:1-3.
41. Parle M, Dhingra D, Kulkarni SK. Improvement of mouse memory by Myristica fragrans seeds. J Med Food 2004;7:157-61.
42. Mukherjee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res 2007;21:1142-5.
43. Tajuddin, Ahmad S, Latif A, Qasmi IA. Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study. BMC Complementary Altern Med 2003;20:3-6.
44. Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrhoeal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol 2002;24:675-80.
45. Gupta S, Yadava JNS, Mehrotra R, Tandon JS. Anti-diarrhoea1 profile of an extract and some fractions from Myristica fragrans (Nutmeg) on escherichia coli enterotoxin-induced secretory response. Pharm Biol 1992;30:179-83.
46. Lee SU, Shim KS, Ryu SY, Min YK, Kim SH. Machilin, an isolated from Myristica fragrans, stimulates osteoblast differentiation. Planta Med 2009;75:152-7.
47. Dhingra D, Sharma A. Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice. J Med Food 2006;9:84-9.
48. Murcia MA, Egea I, Romojaro F, Parras P, Jiménez AM, Martínez-Tomé M. Antioxidant evaluation in dessert spices compared with common food additives. Influence of irradiation procedure. J Agric Food Chem 2004;52:1872-81.
49. Assa JR, Widjanarko SB, Kusnadi J, Berhimpon S. Antioxidant potential of flesh seed and mace of Nutmeg (Myristica fragrans Houtt). Int J ChemTech Res 2014;6:2460-8.
50. Gupta AD, Bansal VK, Babu V, Maithil N. Chemistry, the antioxidant and antimicrobial potential of nutmeg (Myristica fragrans Houtt). J Genet Eng Biotechnol 2013;11:25–31.
51. JY Chung, JH Choo, MH Lee, JK Hwang. The anticarcinogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. Phytomedicine 2006;13:261-6.
52. Jangid K, Jayakumar ND, Varghese SS. Achievable therapeutic effects of Myristica fragrans (Nutmeg) on periodontitis a short review. Int J Pharm Pharm Sci 2014;6:591-4.
53. Jung WC, Jang YS, Hieu TT, Lee CK, Ahn YJ. Toxicity of Myristica fagrans seed compounds against Blatella germanica (Dictyoptera: Blattellidae). J Med Entomol 2007;44:524-9.
54. Park IK, Kim JN, Lee YS, Lee SG, Ahn YJ, Shin SC. Toxicity of plant essential oils and their components against Lycoriella ingenua (Diptera: Sciaridae). J Econ Entomol 2008;101:139-44.
55. Chaubey MK. Fumigant toxicity of essential oils from some common spices against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae). J Oleo Sci 2008;57:171-9.
56. Nguyen PH. AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect. Bioorg Med Chem Lett 2010;20:4128-31.
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How to Cite
Nagja, T., K. Vimal, and A. Sanjeev. “MYRISTICA FRAGRANS: A COMPREHENSIVE REVIEW”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 2, Feb. 2016, pp. 27-30, https://innovareacademics.in/journals/index.php/ijpps/article/view/8552.
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Review Article(s)