ETHNOMEDICINAL, PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITIES OF TRIDAX PROCUMBENS: A REVIEW

  • Vinod Gubbiveeranna Tumkur University
  • S. Nagaraju Department of Studies and Research in Biochemistry, Tumkur University, Tumakuru 572103, Karnataka, India

Abstract

Tridax procumbens is a plant used majorly in Indian traditional medicine. This is rich in alkaloids, steroids, carotenoids, flavonoids (such as catechins, centaurein and bergenins), fatty acids, phytosterols, tannins and minerals. Concoctions of extracts from T. procumbens leaves, stem, flower, and roots are used to treat patients suffering from diabetes, arthritis, inflammatory reactions and even applied to open wounds. The medicinal value of extracts has been evident by in vitro/in vivo assay of antioxidant, anti-bacterial, anti-inflammatory, anti-microbial, vasorelaxant, anti-leishmanial and mosquitocidal activities. Still, there is derth in the studies on isolation, characterization and evaluation of active principles from the extracts. This current review article gives comprehensive information about the T. procumbens taxonomy, morphology, geographical distribution, phytoconstituents and pharmacological activities.

Keywords: Tridax procumbens, Antioxidant, Anti-hepatic, Anti-inflammatory, Anti-arthritic, Anti-microbial, Anti-diabetic, Anti-cancer, Anti-hypertensive, Immunomodulatory, Wound healing, Mosquitocidal, Nanoparticles, Waste water treatment

Downloads

Download data is not yet available.

References

1. Sanjay M Jachak, Raju Gautam, Selvam C, Himanshu Madhan, Amit Srivastava, Taj Khan. Anti-inflammatory, cyclooxygenase inhibitory and antioxidant activities of standardized extracts of Tridax procumbens L. Fitoterapia 2011;82:173-7.
2. Taddei A, Rosas-Romero AJ. Bioactivity studies of extracts from Tridax procumbens. Phytomedicine 2000;7:235-8.
3. Shabeena Yousuf Naqash, Nazeer RA. Anticoagulant, antiherpetic and antibacterial activities of sulphated polysaccharide from Indian medicinal plant Tridax procumbens L. (Asteraceae). Appl Biochem Biotechnol 2011;165:902-12.
4. Jain Ankita, Amita Jain. Tridax procumbens (L.): A weed with immense medicinal importance: a review. Int J Pharma Bio Sci 2012;3:544-52.
5. Kethamakka SRP, Meena S Deograde. Jayanti Veda (Tridax procumbens)-Unnoticed medicinal plant by Ayurveda. J Indian System Med 2014;2:6-20.
6. Yadava RN, Kumar Saurabh. A new flavone glycoside 5,7,4′-trihydroxy-6,3′-dimethoxy flavone 5-O-α-L-rhamnopyranoside from the leaves of Tridax procumbens Linn. J Asian Nat Prod Res 1998;1:147-52.
7. Sunil Christudas, Kulathivel TM, Agastian P. Phytochemical and antibacterial studies of leaves of Tridax procumbens L. Asian Pac J Trop Biomed 2012;2: S159-61.
8. Raghavan TS, Vinkatasubban KR. Contribution to the cytology of Tridax procumbens Linn. Proc Indian Academy Sci 1941;13:85-108.
9. Wen-Hao Chen, Xing-Ming Ma, Quan-Xiang Wu, Yan-Ping Shi. Chemical-constituent diversity of Tridax procumbens. Can J Chem 2008;86:892-8.
10. Zhelmy Martin-Quintal, Maria del Rosario Garcia-Miss, Mirza Mut-Martin, Abril Matus-Moo, Luis W Torres-Tapia, Sergio R Peraza-Sanchez. The leishmanicidal effect of (3S)-16,17-didehydrofalcarinol, an oxylipin isolated from Tridax procumbens, is independent of NO production. Phytother Res 2009;24:1004-8.
11. Jadhav VM, Thorat RM, Kadam VJ, Gholve SB. Kesharaja: Hair vitalizing herbs. Int J Pharm Tech Res 2009;1:454-67.
12. Sneha Mundada, Ruchi Shivhare. Pharmacology of Tridax procumbens a weed: review. Int J PharmTech Res 2010;2:1391-4.
13. Manisha Sutar, Komal Malvankar, Sonia Singh. Pharmacognostical and phytochemical investigation of leaves of a weed Tridax procumbens Linn. Int J Curr Pharm Res 2013;5:29-33.
14. Rahman AHMM, Alam MS, Khan SK, Ferdous Ahmed, Rafiul Islam AKM, Matiur Rahman M. Taxonomic studies on the family asteraceae (compositae) of the Rajshahi division. Res J Agric Biol Sci 2008;4:134-40.
15. Bhagirath S Chauhan, David E Johnson. Germination ecology of two troublesome asteraceae species of rain-fed rice siam weed (Chromolaena odorata) and coat buttons (Tridax procumbens). Weed Sci 2008;56:567-73.
16. Ikewuchi Jude C, Ikewuchi Catherine C, Igboh Ngozi M. Chemical profile of Tridax procumbens Linn. Pak J Nutr 2009;8:548-50.
17. Reddipalli Hemalatha. Anti-hepatotoxic and anti-oxidant defense potential of Tridax procumbens. Int J Green Pharm 2008;2:164-9.
18. Ahamefule FO, Obua BE, Ibeawuchi JA, Udosen NR. The nutritive value of some plants browsed by cattle in Umudike, southeastern Nigeria. Pak J Nutr 2006;5:404-9.
19. Navin Anand Ingle, Harsh Vardhan Dubey, Navpreet Kaur, Rahul Gupta. Tridax procumbens a multiuseful weed: a review. J Adv Oral Res 2014;5:14-6.
20. Harrison Ugo Nwanjo. Aqueous extract of Tridax procumbens leaves effect on lipid peroxidative stress and antioxidant status in chloroquine-induced hepatotoxicity in rats. J Herbs Spices Med Plants 2008;14:154-65.
21. Ondari Nyakundi Erick, Nalini Padmanabhan M. Antimicrobial activity of biogenic silver nanoparticles synthesized using Tridax procumbens L. Int J Curr Res Acad Rev 2014;2:32-40.
22. Udupa AL, Kulkarni DR, Udupa SL. Effect of Tridax procumbens extracts on wound healing. Int J Pharmacogn 1995;33:37-40.
23. Muhammad Shaiq Ali, Muhammad Jahangir. A bis-bithiophene from Tridax procumbens L. (Asteraceae). Nat Prod Lett 2002;16:217-21.
24. Vilwanathan Ravikumar, Kanchi Subramanian Shivashangari, Thiruvengadam Devaki. Hepatoprotective activity of Tridax procumbens against d-galactosamine lipopolysaccharide-induced hepatitis in rats. J Ethnopharmacol 2005;101:55-60.
25. Nazeruddin GM, Shirish S Pingale, Samir S Shaikh. Pharmacological review of Tridax procumbens L. Pharm Sin 2011;2:172-5.
26. Vilwanathan Ravikumar, Kanchi Subramanian Shivashangari, Thiruvengadam Devaki. Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galactosamine sensitised rats. Mol Cell Biochem 2005;269:131-6.
27. Joshi PP, Patil SD, Silawat N, Deshmukh PT. Effect of Tridax procumbens (Linn.) on bile duct ligation-induced liver fibrosis in rats. Nat Prod Res 2011;25:1975-81.
28. Awasthi S, Irshad M, Das MK, Ganti SS, Moshahid A Rizvi. Anti-inflammatory activity of Calotropis gigantea and Tridax procumbens on carrageenin-induced paw edema in rats. Ethnobotanical Leaflets 2009;13:568-77.
29. Saumya Das, Sanjita Das, Manas Kumar Das, Saumya Priya Basu. Evaluation of anti-inflammatory effect of Calotropis gigantea and Tridax procumbens on wistar albino rats. Pharm Sci Res 2009;1:123-6.
30. Margaret I, Reddy P Srinivasa, Jamil Kaiser. Antiinflammatory profile of Tridax procumbens in animal and fibroblast cell models. Phytother Res 1998;12:285-7.
31. Sudarshan Sawant, Virendra Chine, Annasaheb Kalange, Parag Joshi, Vaibhavkumar Gawali, Shuvranshu Narayan Praharaj, et al. Evaluation of lyophilized extract of leaves of Tridax procumbens Linn. in rodent models of inflammatory and neuropathic pain. Oriental Pharm Exp Med 2014;14:163-7.
32. Ramesh Petchi R, Vijaya C, Parasuraman S. Anti-arthritic activity of ethanolic extract of Tridax procumbens (Linn.) in sprague dawley rats. Pharmacogn Res 2013;5:113-7.
33. Umesh Tiwari, Bhawna Rastogi, Paramjit Singh, Dinesh K Saraf, Suresh P Vyas. Immunomodulatory effects of aqueous extract of Tridax procumbens in experimental animals. J Ethnopharmacol 2004;92:113-9.
34. Oladunmoye MK. Immunomodulatory effects of ethanolic extract of Tridax procumbens on swiss albino rats orogastrically dosed with Pseudomonas aeruginosa. Int J Trop Med 2006;1:152-5.
35. Rajinder Raina, Srivastava AK, Shahid Prawez, Azad Ahmad. Therapeutic potential of plants in wound healing. Curr Pharm Des 2012;18:1421-33.
36. Rajinder Raina, Shahid Prawez, Verma PK, Pankaj NK. Medicinal plants and their role in wound healing. Acta Vet Scand 2008;3:1-7.
37. Kumara B, Vijayakumar M, Govindarajan R, Pushpangadan P. Ethnopharmacological approaches to wound healing–exploring medicinal plants of India. J Ethnopharmacol 2007;114:103-13.
38. Satish A Bhalerao, Tushar S Kelkar. Phytochemical and pharmacological potential of Tridax procumbens Linn. Int J Adv Biotechnol Res 2012;2:392-5.
39. Sudeendra Bhat R, Shankrappa J, Shivakumar HG. Formulation and evaluation of polyherbal wound treatments. J Pharm Sci 2007;2:11-7.
40. Diwan PV, Tilloo LD, Kulkarni DR. Steroid depressed wound healing and Tridax procumbens. Indian J Physiol Pharmacol 1983;27:32-6.
41. Rao PK, Hasan SS, Bhellum BL, Manhas RK. Ethnomedicinal plants of Kathua district J and K India. J Ethnopharmacol 2015;171:12-27.
42. Manjamalai A, Mahesh Kumar MJ, Berlin Grace VM. Essential oil of Tridax procumbens L. induces apoptosis and suppresses angiogenesis and lung metastasis of the B16F-10 cell line in C57BL6 mice. Asian Pacific J Cancer Prevention 2012;13:5887-95.
43. Vishnu Priya P, Radhika K, Siva Kumar R, Boje Gowda B, Syed Sultan Beevi, Prameela Devi Y, et al. In vitro anticancer activity of aqueous and acetone extracts of Tridax procumbens leaf on PC 3 cell lines. Int J Pharm Pharm Studies 2011;3:1-4.
44. Vishnu Priya P, Radhika K, Siva Kumar R, Sri Ramchandra M, Prameela Devi Y, Srinivas Rao. Evaluation of anti-cancer activity of Tridax procumbens flower extracts on PC 3 cell lines. Pharmanest 2011;2:28-30.
45. Priyam Singh, Rajni Shrivastava, Manik Sharma, Matadeen. Ethnomedicinal drug discovery for cancer through accumulated facts and novel drug delivery systems-a review. Indian J Biotechnol Pharm Res 2013;1:1-8.
46. Sankaranarayanan S, Bama P, Sathyabama S, Bhuvaneshwari N. Anticancer compound isolated from the leaves of Tridax procumbens against human lung cancer cell A-549. Asian J Pharm Clin Res 2013;6:91-6.
47. Jude C Ikewuchi, Eugene N Onyeike, Augustine A Uwakwe, Catherine C Ikewuchi. Effect of aqueous extract of the leaves of Tridax procumbens Linn. on blood pressure components and pulse rates of sub chronic salt-loaded rats. Pacific J Sci Technol 2011;12:381-9.
48. Salahdeen HM, Yemitan OK, Alada ARA. Effect of aqueous leaf extract of Tridax procumbens on blood pressure and heart rate in rats. Afr J Biomed Res 2004;7:27-9.
49. Hussein M Salahdeen, Gbolahan O Idowu, Omoniyi K Yemitan, Babatunde A Murtala, Abdul-Rasak A Alada. Calcium-dependent mechanisms mediate the vasorelaxant effects of Tridax procumbens (Lin) aqueous leaf extract in rat aortic ring. J Basic Clin Physiol Pharmacol 2014;25:161-6.
50. Hussein M Salahdeen, Babatunde A Murtala. Vasorelaxant effects of aqueous leaf extract of Tridax procumbens on aortic smooth muscle isolated from the rat. J Smooth Muscle Res 2012;48:37-45.
51. Hussein M Salahdeen, Gbolahan O Iduwu, Babatunde A Murtala. Endothelium dependant and independent vasorelaxant effects of aqueous extract of Tridax procumbens Lin. leaf in rat aortic rings. Indian J Exp Biol 2012;50:883-8.
52. Bharathi V, Varalakshmi B, Gomathi S, Shanmuga Priya A, Karpagam T. Antibacterial activity of Tridax procumbens Linn. Int J Pharma Sci Res 2012;3:364-7.
53. Sharma B, Kumar P. Extraction and pharmacological evaluation of some extracts of Tridax procumbens and Capparis deciduas. Int J Appl Res Nat Prod 2009;1:5-12.
54. Alka Jindal, Padma Kumar. Antimicrobial flavonoids from Tridax procumbens. Nat Prod Res 2012;26:2072-7.
55. Mahato RB, Chaudhary RP. Ethnomedicinal study and antibacterial activities of selected plants of Palpa district, Nepal. Sci World 2005;3:26-31.
56. Kale M, Dhake A. Anti-bacterial potential of Tridax procumbens leaf extracts against some clinical pathogens. J Nat Prod Plant Resour 2013;3:34-7.
57. Policegoudra RS, Chattopadhyay P, Aradhya SM, Shivaswamy R, Singh L, Veer V. Inhibitory effect of Tridax procumbens against human skin pathogens. J Herbal Med 2004;4:83-8.
58. Zhelmy Martin-Quintal, Rosa Moo-Puc, Francisco Gonzalez-Salazar, Manuel J Chan-Bacab, Luis W Torres-Tapia, et al. In vitro activity of Tridax procumbens against promastigotes of Leishmania mexicana. J Ethnopharmacol 2009;122:463-7.
59. Rubi Gamboa-Leon, Marina Vera-Ku, Sergio R Peraza-Sanchez, Carloz Ku-Chulim, Aurelio Horta-Baas, Miguel Rosado-Vallado. Antileishmanial activity of a mixture of Tridax procumbens and Allium sativum in mice. Parasite 2014;21:1-7.
60. Durgacharan A Bhagwat, Suresh G Killedar, Rahul S Adnaik. Anti-diabetic activity of leaf extract of Tridax procumbens. Int J Green Pharm 2008;2:126-8.
61. Hemanth Pareek, Sameer Sharma, Balvant S Khajja, Kusum Jain, Jain GC. Evaluation of the hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn.). BMC Complementary Altern Med 2009;9:1-7.
62. Muhammad Shaiq Ali, Muhammad Jahangir, Syed Shazad ul Hussan, Muhammad Iqbal Choudhary. Inhibition of a-glucosidase by oleanolic acid and its synthetic derivatives. Phytochemistry 2002;60:295-9.
63. Rajkumar S, Jebanesan A. Repellent activity of selected plant essential oils against the malarial fever mosquito Anopheles stephensi. Asian Pac J Trop Biomed 2007;24:71-5.
64. Abubakar A, Ogbadoyi EO, Okogun JI, Gbodi TI, Tifin UF. Acute and sub chronic toxicity of Tridax procumbens in experimental animals. IOSR J Environ Sci Toxicol Food Technol 2012;1:19-27.
65. Hari Prasad M, Ramesh C, Jayakumar N, Ragunathan V, Kalpana D. Biosynthesis of bimetallic Ag/Cu2O nanocomposites using Tridax procumbens leaf extract. Adv Sci Eng Med 2012;4:85-8.
66. Pathode NH, Parwate DV, Das Sharma I. Separation of Zn(II) and Cd(II) ions from synthetic waste water by adsorption on activated carbon derived from Tridax procumbens. Anal Chem Lett 2014;4:113-22.
67. Malairajan Singanan, Alemayehu Abebaw, Vinodhini Singanan. Studies on the removal of hexavalent chromium from industrial wastewater by using biomaterials. EJEAFChe Electron J Environ Agric Food Chem 2007;6:2557-64.
68. Malairajan Singanan. Defluoridation of drinking water using metal embedded biocarbon technology. Int J Environ Health Eng 2013;5:150-60.
69. Malairajan Singanan. Biosorption of Hg(II) ions from synthetic wastewater using a novel biocarbon technology. Environ Eng Res 2015;20:33-9.
70. Singanan M, Singanan V, Abebaw A. Biosorption of Cr (III) from aqueous solutions using indigenous biomaterials. Int J Environ Res 2008;2:177-82.
71. Saratu Mamman, Ismaila Abdullahi, Reuben O Ukwede. Isotherms and batch kinetics of the biosorption of cadmium onto pre-treated Tridax procumbens. Der Parma Chemica 2011;3:94-101.
72. Mogammed Ali, Earla Ravinder, Ramidi Ramachandran. A new flavonoid from the aerial parts of Tridax procumbens. Fitoterapia 2001;72:313-5.
73. Saxena VK, Sosanna Albert. β-Sitosterol-3-O-β-D-xylopyranoside from the flowers of Tridax procumbens Linn. J Chem Sci 2005;117:263-6.
74. Ram K Verma, Madan M Gupta. Lipid constituents of Tridax procumbens. Phytochemistry 1983;27:459-63.
75. Shantha Raju T, Davidson EA. Structural features of water-soluble novel polysaccharide components from the leaves of Tridax procumbens Linn. Carbohydr Res 1994;258:243-54.
Statistics
873 Views | 6426 Downloads
How to Cite
Gubbiveeranna, V., and S. Nagaraju. “ETHNOMEDICINAL, PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITIES OF TRIDAX PROCUMBENS: A REVIEW”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 2, Feb. 2016, pp. 1-7, https://innovareacademics.in/journals/index.php/ijpps/article/view/8973.
Section
Review Article(s)