ACCELERATED STABILITY STUDY OF CHITRAK HARITAKI AVALEHA

  • Varun Kumar Singh
  • M. K. Nandi
  • Narendra Kumar Singh Department of Rasa Shastra, Faculty of Ayurveda, BHU, Varanasi, 221005

Abstract

Objective: Accelerated stability study of Chitrak Haritaki avaleha was done for six months to know the stability of formulation in reference of its phyto-constituents and microbial growth therein.

Methods: Chitrak Haritaki avaleha was made in laboratory following classical method [Sample lab (SL)] as per AFI part-1(The Ayurvedic formulary of India, part-1) and two samples were collected from local market [Market Sample-1(MK-1) & Market sample-2 (MK-2)] of reputed brand. These three samples were put in controlled condition following ICH (International Conference on Harmonization) guidelines for accelerated stability study for six months. The intermediate samplings were done at starting, after one, three and six month respectively. These samples were investigated for reducing sugar, phyto-constituents (Total tannins, piperine, vitamin C and total polyphenols contents), microbial load and their organoleptic characteristics.

Results: All the results were calculated and compared for variation during course of time. Variation in the result of samples was evaluated against Arrhenius equation which ensured that formulation was stable over two years and no significant variation was found over six month of accelerated stability condition.

Conclusion: Since it is traditional avalehakalpana, the shelf life period was about one year (Sharangdhar Samhita) and updated to three year in Drug and cosmetic rule 1945, 161B. The presented study reflect that Chitrak Haritaki avaleha was stable over two year (by taking inference from Arrhenious equation) and more sophisticated packing may improve the shelf life period.

Keywords: Avaleha, Shelf life, Accelerated stability, Chitrak Haritaki avaleha.

Downloads

Download data is not yet available.

References

1. Anonymous. The Ayurvedic Pharmacopoeia of India. Ministry of health and family welfare. Dept. of Indian systems of medicine and homeopathy: New Delhi; 2004. p. 10-2.
2. Anonymous. The Ayurvedic Formulary of India. Ministry of health and family welfare. Dept. of Indian systems of medicine and Homeopathy: New Delhi; 2004. p. 10.
3. Sharangdhar, Sharangadhar Samhita. Commentary by Brahmanand Tripathi, Poorva Khand; 2011.
4. Malik V. Law relating to drugs and cosmetics. 22nd edition. Estern book company: Lucknow, Rule 161B; 2014. p. 225.
5. Mukherjee PK, Ponnusankar S, Venkatesh P. Synergy in herbal medicinal products: concept to realization. Ind J Pharm Edu Res 2011;45:210-7.
6. Das G, Bhaisajya Ratnawali. Commentary by ambikadatt shastri. 18thed. Choukhambha publication: Varanasi, Nasaroga Chikitsa Prakaran; 2005. p. 987.
7. Anonymous. World Health Organization. WHO Technical Report Series No. 953. Annex-2Stability testing of active pharmaceutical ingredients and finished pharmaceutical products; 2009.
8. Siddiqua A, Premakumari KB, Sultana R, Vithya, Savitha. Antioxidant activity and estimation of total phenolic content of muntingia calabura by colorimetry. Int J Chem Tech Res 2010;2:205-8.
9. Makkar HPS, Bluemmel M, Borowy NK, Becker K. Gravimetric determination of tannins and their correlations with chemical and protein precipitation methods. J Sci Food Agric 1993;63:161–5.
10. Teepoo S. A new simple and rapid colorimetric screening test for semi-qualitative analysis of vitamin c in fruit juices based on prussian blue. J Appl Sci 2012;12:568-74.
11. Singh NK. UV-spectrophotometric method development for estimation of piperine in Chitrakadivati. Pharm Lett 2011;3:178-82.
12. Anonymous. The Ayurvedic Pharmacopoeia of India. 1st Ed. Govt. of India, Ministry of Health and Family Welfare: New Delhi; 2008. p. 163.
13. Singh E, Sharma S, Pareek A, Dwivedi J, Yadav S, Sharma S. Phytochemistry, traditional uses and cancer chemopreventive activity of Amla (Phyllanthusemblica): the sustainer. J Appl Pharm Sci 2011;2:176-83.
14. Vasavirama K, Upender M. Piperine: a valuable alkaloid from piper species. Int J Pharm Pharm Sci 2014;6:34-8.
15. Lohar DR. Protocol for testing of ASU medicine. PLIM, Department of AYUSH: Gaziabad; 1940. p. 36.
16. Sungthongjeen S. Application of arrhenius equation and plackett-burman design to ascorbic acid syrup development. Naresuan University J 2004;12:1-12.
Statistics
290 Views | 1171 Downloads
How to Cite
Singh, V. K., M. K. Nandi, and N. K. Singh. “ACCELERATED STABILITY STUDY OF CHITRAK HARITAKI AVALEHA”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 2, Feb. 2016, pp. 221-3, https://innovareacademics.in/journals/index.php/ijpps/article/view/9118.
Section
Original Article(s)