A CASE REPORT: DRUG INTERACTION BETWEEN LINEZOLID AND DOPAMINE


Smitha S1, Vidya Alex, Suja Abraham, Sreeja Pa

Abstract


Linezolid is a weak, non-selective inhibitor of monoamine oxidase (MAO). It can inhibit the breakdown of the tyramine by MAO in the gut and can also potentiate the effect of tyramine at nerve endings, thereby causing an increase in blood pressure. We encountered a neonate who developed acute hypertensive episode after simultaneous administration of dopamine and linezolid. A 25 w preterm neonate was admitted in NICU (Neonatal Intensive Care Unit) with complaints of Patent Ductus Arteriosus and respiratory infection. Linezolid infusion 6.5 mg every 8 h over 30 min (7 am, 3pm, 11 pm) was added after confirmation of gram-positive cocci (Staphylococcus epidermis) growth. Inj. Dopamine 20 mcg/kg/min was started for derangement in blood pressure 52/28 mm Hg (Mean blood pressure 43) at 5 pm. The baby developed acute hypertensive episode at 5.30 pm for which dopamine was withdrawn immediately. The half-life of Linezolid is 5.6 h in preterm baby, and that of Dopamine is 2 min. Since the probability of peak concentration for both the administered drugs was around the same time period, the baby developed acute hypertensive episode. So the combination of Linezolid with Dopamine should be avoided if possible or the dosage interval has to be extended to minimize the adverse reaction.

 


Keywords


Linezolid, Acute hypertension, Neonatal Intensive Care Unit

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About this article

Title

A CASE REPORT: DRUG INTERACTION BETWEEN LINEZOLID AND DOPAMINE

Keywords

Linezolid, Acute hypertension, Neonatal Intensive Care Unit

Date

25-11-2015

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 8, Issue 1, 2016 Page: 467-468

Online ISSN

0975-1491

Statistics

338 Views | 96 Downloads

Authors & Affiliations

Smitha S1, Vidya Alex
Department of Pharmacy Practice, Grace College of Pharmacy, Palakkad, Kerala 678004
India

Suja Abraham
Clinical pharmacist, Aster Medicity, Ernakulum
India

Sreeja Pa
Grace College of Pharmacy
India


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