SIRT6 IS CORRELATED WITH ESTRADIOL IN WOMEN WITH IN VITRO FERTILIZATION FAILURE
Objective: In vitro fertilization (IVF) is an important tool and it is widely used in the treatment of infertility. However, the failure rate is still high. Thus the study of the factors affecting the rate of success of IVF cycles is very important field of study. In the present study, the possible relationship between the Sirtuin-6 (SIRT6), a stress-responsive protein deacetylase, and the outcome of IVF was studied. SIRT6 also was correlated with hormone levels in women with IVF failure.
Methods: Sixty women undergo IVF patients were participated in the study. Women group that had conceived from IVF are expressed as "pregnant group" while women who hadn't are expressed as "failure group." All groups had same preparations and same treatment regimen.
Results: Results revealed that there is an insignificant difference between pregnant and failure groups in serum SIRT6 level. The results showed a significant higher estradiol, and lower prolactin and antimullerian hormone in pregnant in comparing with failure group. Correlations studies indicated no significant correlation between SIRT6 and hormones in pregnant group, while there is a significant correlation between SIRT6 and estradiol hormone in the failure group.
Conclusion: It can be concluded that serum SIRT6 level does not differ between women who had success or failure IVF. However, in women with failure, SIRT6 is correlated with estradiol level.
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