INCIDENCES OF-AND RISK FACTOR FOR NEW ONSET DIABETES AFTER TRANSPLANTATION IN LIVE DONOR KIDNEY TRANSPLANTATION: A PROSPECTIVE SINGLE CENTRE STUDY
Objective: The objective of present study was to evaluate incidence and risk factors for the development of new-onset diabetes after transplantation (NODAT) after kidney transplantation at our center.
Methods: A total 79 nondiabetic patients who underwent living donor kidney transplantation from January 2014 to August 2014 were prospectively enrolled. All the patients were followed for one year. All the patients received the same protocol of immunosuppressive therapy. NODAT was defined as if a patient had HbA1c â‰¥ 6.5%, fasting venous plasma glucose â‰¥126 mg/dl, or was receiving diet or medical therapy for diabetes.
Results: The incidence of NODAT was 29.9% after one year. Risk factors associated with the development of NODAT included older age (OR: 1.07; p<0.05), family history (OR: 3.58; P<0.05), hepatitis C virus (HCV) positivity (OR: 11.15; p<0.05), obesity (OR: 4.28; p<0.05), pre-transplant triglycerides (OR: 1.01; p<0.005) and cholesterol level (OR: 1.01; p<0.005).
Conclusion: The prevalence of potentially modifiable risk factors in our study cohort was overweight recipients and pretransplant HCV infection, serum triglycerides, and cholesterol levels.
Keywords: New-onset Diabetes after transplantation, Kidney transplantation, Tacrolimus, Hepatitis C virus.
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