VECURONIUM AND CARDIAC ARREST
Abstract
Vecuronium is widely used to provide skeletal muscle relaxation in mechanically ventilated Intensive Care Unit patients. The absence of significant cardiovascular side-effects is one of its stated advantages. There have been isolated reports of Brady-dysrhythmias including sinus arrest and atrioventricular block when vecuronium was administered with other agents especially opioids. We report a case of cardiac arrest following administration of vecuronium alone in a mechanically ventilated child in the Intensive Care Unit.
Keywords: Vecuronium, Sinus arrest, Atrioventricular block.
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References
1. Booij LHDJ, Edwards RP, Sohn, YJ. Cardiovascular and neuromuscular effects of ORG NC45, pancuronium, metocurine and d-tubocurarine in dogs. Anesth Analg 1980;59:26-30.
2. May JR. Vecuronium and bradycardia. Anaesthesia 1985;40:410.
3. Kirkwood I, Duckworth RA. An unusual case of sinus arrest. Br J Anaesth 1983;55:1273.
4. Clayton D. Asystole associated with vecuronium. Br J Anaesth 1986;58:937-8.
5. Starr NJ, Sethna DH, Estafanous FG. Bradycardia and asystole following the rapid administration of sufentanil with vecuronium. Anesthesiology 1986;64:521-3.
6. Cozanitis DA, Erkola O. A clinical study into the possible intrinsic bradycardia activity of vecuronium. Anaesthesia 1989;44:648-50.
7. Inoue K, EI-Banayosy A, Stolarsky L. Vecuronium-induced bradycardia following induction of anaesthesia with etomidate and thiopentone with or without fentanyl. Br J Anaesth 1988;60:10-3.
8. Salmenpera M, Peltola K, Takkunen O. Cardiovascular effects of pancuronium and vecuronium during high-dose fentanyl anesthesia. Anesth Analg 1983;62:1059-64.
9. Cozanitis DA, Pouttu J, Rosenberg PH. Bradycardia associated with the use of vecuronium. A comparative study with pancuronium with and without glycopyrronium. Anaesthesia 1987;42:192-4.
10. Yeaton P, Teba L. Sinus node exit block following administration of vecuronium. Anaesthesia 1988;68:177-8.
2. May JR. Vecuronium and bradycardia. Anaesthesia 1985;40:410.
3. Kirkwood I, Duckworth RA. An unusual case of sinus arrest. Br J Anaesth 1983;55:1273.
4. Clayton D. Asystole associated with vecuronium. Br J Anaesth 1986;58:937-8.
5. Starr NJ, Sethna DH, Estafanous FG. Bradycardia and asystole following the rapid administration of sufentanil with vecuronium. Anesthesiology 1986;64:521-3.
6. Cozanitis DA, Erkola O. A clinical study into the possible intrinsic bradycardia activity of vecuronium. Anaesthesia 1989;44:648-50.
7. Inoue K, EI-Banayosy A, Stolarsky L. Vecuronium-induced bradycardia following induction of anaesthesia with etomidate and thiopentone with or without fentanyl. Br J Anaesth 1988;60:10-3.
8. Salmenpera M, Peltola K, Takkunen O. Cardiovascular effects of pancuronium and vecuronium during high-dose fentanyl anesthesia. Anesth Analg 1983;62:1059-64.
9. Cozanitis DA, Pouttu J, Rosenberg PH. Bradycardia associated with the use of vecuronium. A comparative study with pancuronium with and without glycopyrronium. Anaesthesia 1987;42:192-4.
10. Yeaton P, Teba L. Sinus node exit block following administration of vecuronium. Anaesthesia 1988;68:177-8.
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How to Cite
Sahoo, B. “VECURONIUM AND CARDIAC ARREST”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 2, Feb. 2016, pp. 342-3, https://innovareacademics.in/journals/index.php/ijpps/article/view/9670.
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