IMMUNOMODULATORY EFFECTS OF ALGERIAN CAPER


Ridha Aichour, Noureddine Charef, Abderrahmane Baghiani, Lekhmici Arrar

Abstract


Objective: The aim of this study is to investigate the immunomodulatory properties of fruits and leaves of Capparis spinosa in mice.

Methods: The effect of methanolic extracts of C. spinosa on immune system were assessed by applying several approaches such as Lymphocyte proliferation assay in presence of mitogen (Concanavalin A), delayed-type hypersensitivity (DTH) response, humoral response and Cyclophosphamide-induced immunosuppression.

Results: Administration of methanolic extracts at doses 100 and 200 mg/kg produced statistically significant results as evidenced by the increase in delayed type hypersensitivity (DTH) response (P<0.05), enhanced the total WBC level in the cyclophosphamide induced myelosuppression model (p<0.01). These extracts also showed significant increase in humoral antibody (HA) titre (P<0.05, P<0.01) at dose 200 mg/ml. Equally, C. spinosa extracts evoked a significant (p<0.05, P<0.01) increase in mitogen-induced lymphocyte proliferation.

Conclusions: The results demonstrated that both the plant parts extracts exert a marked immunostimulatory effect on the mouse immune system.


Keywords


Capparis spinosa, Immunomodulatory properties, Hypersensitivity, Humoral response, Lymphocyte proliferation

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About this article

Title

IMMUNOMODULATORY EFFECTS OF ALGERIAN CAPER

Keywords

Capparis spinosa, Immunomodulatory properties, Hypersensitivity, Humoral response, Lymphocyte proliferation

Date

01-02-2016

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 8, Issue 2, 2016 Page: 51-54

Online ISSN

0975-1491

Authors & Affiliations

Ridha Aichour
Laboratory of Applied Biochemistry, Faculty of Nature and Life Science, University Setif 1, Algeria
Algeria

Noureddine Charef
University Setif
Algeria

Abderrahmane Baghiani
University Setif
Algeria

Lekhmici Arrar
University Setif
Algeria


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