CYTOTOXIC AND THROMBOLYTIC ACTIVITY OF ROOT EXTRACT OF MUSA PARADISIACA (FAMILY: MUSACEAE)
Objective: To evaluate for cytotoxicity and thrombolytic activity.
Methods: The cytotoxic activity was investigated by using brine shrimp nauplii. The ethanol extract was prepared by dissolving them in DMSO (not more than 50 ÂµL in 5 mL solution) with sea water (3.8% NaCl in water) using concentrations 6.25, 12.5, 25, 50, 100, 300 and 500 Âµg/mL. The extract was also evaluated for thrombolytic effect using clot lysis analysis at the concentration of 500Âµg, 800Âµg and 1000Âµg.
Results:The ethanol extract of M. paradisiaca showed cytotoxic activity against brine shrimp nauplii and LC50 value was 25 Âµg/ mL and thrombolytic activity was also investigated in our research that the % of clot lysis were 3.27, 7.59 and 13.04 at the concentration of 500Âµg, 800Âµg and 1000Âµg respectively.
Conclusion:This is only a preliminary study.Further studies are necessary to evaluate the exact mechanism behind these activity.
Â Key Words: Musa paradisiaca;ethanol extract; brine shrimp nauplii:cytotoxic Activity; thrombolytic Activity
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