ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF METHANOLIC SEED EXTRACT OF STERCULIA VILLOSA ROXB.

  • H. M. Arif Ullah Gyeongsang National University
  • Lucky Akter Department of Pharmacy, School of Life Sciences, North South University
  • Sayera Zaman Department of Pharmacy, School of Life Sciences, North South University
  • Fatematuj Juhara Department of Pharmacy, School of Life Sciences, North South University
  • Syed Mohammed Tareq Department of Pharmacy, Faculty of Science and Engineering, Southern University
  • Rajib Bhattacharjee Department of Pharmacy, School of Life Sciences, North South University
  • Hye Jin Chung Gyeongsang National University

Abstract

objective: To scientifically validate the analgesic and anti-inflammatory properties of methanolic seed extract of Sterculia villosa Roxb. (SVME) in
animal models.
Methods: Analgesic activity of SVME was evaluated by the hot plate-induced pain model, acetic acid-induced abdominal writhing response, and
formalin test in mice at the doses of 250 and 500 mg/kg. A carrageenan-induced paw edema model was also used to evaluate anti-inflammatory
potential of SVME in rats at doses of 250 and 500 mg/kg.
Results: Phytochemical analysis revealed the presence of flavonoid, gums and carbohydrates, steroids, alkaloid, reducing sugar, and terpenoids in
significant amounts. The SVME produced significant analgesic activity in the hot-plate test in mice at all the time points measured. Extracts of 250 and
500 mg/kg reduced dose-dependent acetic acid-induced writhing by 40.2% (p<0.01) and 59.8% (p<0.001), respectively. Significant inhibition
of formalin-induced pain was also observed, with inhibition of 62.1% (p<0.001) and 66.7% (p<0.001) in the early phase at dosages of 250 and
500 mg/kg, respectively, and 64.4% (p<0.01) and 70.3% (p<0.01) in the late stage at these dosages. SVME pretreatments showed significant antiinflammatory
activity
against
carrageenan-induced
edema at all the time points measured.
Conclusion: The results suggest that SVME possesses analgesic and anti-inflammatory activities. These findings provide support use of this plant in
traditional medicine to treat pain and inflammation.
Keywords: Sterculia villosa Roxb., Analgesic, Anti-inflammatory, Carrageenan.

 

Author Biography

Hye Jin Chung, Gyeongsang National University

Assistant Professor

College of Pharmacy

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How to Cite
Ullah, H. M. A., L. Akter, S. Zaman, F. Juhara, S. M. Tareq, R. Bhattacharjee, and H. J. Chung. “ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF METHANOLIC SEED EXTRACT OF STERCULIA VILLOSA ROXB.”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 5, Sept. 2015, pp. 247-51, https://innovareacademics.in/journals/index.php/ajpcr/article/view/7564.
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