PROPHYLACTIC AND CURATIVE EFFECT OF ETHANOLIC EXTRACT OF BASSIA MALABARICA BARK AGAINST CISPLATIN INDUCED NEPHROTOXICITY
Objective: The present study was designed to investigate the prophylactic and curative effect of ethanolic extract of Bassia malabarica bark (EBBM)
against cisplatin (7 mg/Kg single dose i. p) induced nephrotoxicity in male albino rats of Wistar strain.
Materials and Methods: After the treatment schedule for 15 days, the extent of nephrotoxicity was quantified using serum samples and isolated
kidneys. Serum samples were used to assess levels of protein, creatinine, urea, uric acid and blood urea nitrogen (BUN). The isolated kidneys were
used to assess antioxidants such as lipid peroxidation (LPO), reduced glutathione (GSH) and catalase (CAT).
Results: No mortality was observed in acute toxicity studies conducted as per organization for economic co-operation and development guidelines
423 and was found to be safe with no gross behavioral changes up to 2000 mg/Kg body weight (bwt). On administration of cisplatin there was a rise
in weight of the kidney, creatinine, urea, uric acid, BUN, LPO and a decrease in bwt, urine volume, total protein, GSH and CAT indicating the role of
oxidants to induce nephrotoxicity.
Conclusion: Prophylactic and curative groups were found to ameliorate the cisplatin induced alterations in the kidney in a dose-dependent manner.
Keywords: Antioxidants, Bassia malabarica, Cisplatin, Nephrocurative, Nephroprotective
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