PROSPECTIVE OBSERVATIONAL STUDY ON MYOCARDIAL INFARCTION IN RELATIONSHIP WITH VARIOUS RISK FACTORS

Authors

  • Linu P Baby
  • Neema Johnson
  • Shyamily John
  • KamesWaran R J.K.K.NATTRAJA COLLEGE OF PHARMACY
  • Sambathkumar R

DOI:

https://doi.org/10.22159/ajpcr.2016.v9s3.13735

Abstract

ABSTRACT
Objective: The aim of this study was to determine the prevalence of risk factors which influence the increased rate of myocardial infarction in a
tertiary care hospital.
Methods: Data for this 6 months prospective observational study were collected from 227 patients admitted to a tertiary care hospital with acute
myocardial infarction, through patient interviews and case reports and were analyzed.
Results: A total of 227 cases were taken for this study. Out of 227 patients, 168 (74.19%) were males and 59 (25.81%) were females. This study
reveals some major risk factors which contribute the increased rate of myocardial infarction and were smoking, chronic alcoholism, obesity, sedentary
lifestyle, male sex, physical inactivity, comorbid diseases, sleep disorders as well as age group between 41 and 60 years. No association between oil
consumption coffee intake and a positive association between tea intake was observed. Out of 105 patients diagnosed with ST elevated MI, 55 (52.23%)
were treated with fibrinolytic therapy and 50 (47.77%) were excluded from this therapy mainly due to delayed admission. All the patients were found
to be benefited by beta-blocker therapy.
Conclusion: Results suggested that awareness regarding moderate physical activity, cessation of cigarette smoking, increased daily consumption of
fruits and vegetables may reduce the increased myocardial infarction risk.
Keywords: Myocardial infarction, Risk factors, Fibrinolytic therapy, Beta blockers.

References

Yusuf S, Reddy S, Ounpuu S, Anand S. Global burden of cardiovascular diseases: Part I: General considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 2001;104(22):2746-53.

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifible risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study. Lancet 2004;364(9438):937-52.

Gupta R, Joshi P, Mohan V, Reddy KS, Yusuf S. Epidemiology and causation of coronary heart disease and stroke in India. Heart 2008;94(1):16-26.

The Joint European Society of Cardiology/American College of Cardiology Committee. Myocardial infarction redefined—A consensus document of the joint European Society of Cardiology/American College of Cardiology for the redefinition of myocardial infarction. EurHeart J 2000;21:1502-13.

Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: Global burden of disease study. Lancet 1997;349(9061):1269-76.

Enas EA, Senthilkumar A. Coronary artery disease in Asian Indians: An update and review. Int J Cardiol 2002;1(2):1-34.

McGill HC Jr, McMahan CA, Zieske AW, Tracy RE, Malcom GT, Herderick EE, et al. Association of coronary heart disease risk factors with microscopic qualities of coronary atherosclerosis in youth. Circulation 2000;102(4):374-9.

Tanna NA, Srivastava RS, Tanna VA, Vaishnani HV. The role of unknown risk factors in myocardial infarction. Int J Biomed Adv Res 2013;4(6):6-10.

Hanratty B, Lawlor DA, Robinson MB, Sapsford RJ, Greenwood D, Hall A. Sex differences in risk factors, treatment and mortality after acute myocardial infarction: An observational study. J Epidemiol Community Health 2000;54(12):912-6.

Ding YL, Fuu JT, Chang HT, Chih YH. Mechanisms governing the protective effect of 17b-estradiol and estrogen receptors against cardiomyocyte injury. Bio Med 2011;4:21-8.

Shraddha C, Bani TA. Prevalence of cardiovascular disease in India and it is economic impact - A review. Int J Sci Res Publ 2013;3(10):10-7.

Bergström G, Redfors B, Angerås O, Dworeck C, Shao Y, Haraldsson I, et al. Low socioeconomic status of a patient’s residential area is associated with worse prognosis after acute myocardial infarction in Sweden. Int J Cardiol 2015;182:141-7.

Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 2010;56(14):1113-32.

Ismail J, Jafar TH, Jafary FH, White F, Faruqui AM, Chaturvedi N. Risk factors for non-fatal myocardial infarction in young South Asian adults. Heart 2004;90(3):259-63.

Meisinger C, Heier M, Löwel H, Schneider A, Döring A. Sleep duration and sleep complaints and risk of myocardial infarction in middle-aged men and women from the general population: The MONICA/KORA Augsburg cohort study. Sleep 2007;30(9):1121-7.

Rao V, Rao P, Carvalho N. Risk factors for acute myocardial infarction in Coastal region of India: A case control study. Heart India 2014;2(3):70-5.

Howard DS, Michael GJ, Julie EB, Charles HH. Coffee and tea intake and the risk of myocardial infarction. Am J Epidemiol 1991;149(2):162-7.

Amir M. Association between consumption of dairy products and serum lipids in subjects with coronary heart disease. Public Health Nutr 2013;1:1-39.

Campos H, Baylin A, Willett WC. Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. Circulation 2008;118(4):339-45.

Conrado SD. Coconut oil: Atherogenic or not? Philipp J Cardiol 2003;31(3):97-104.

Thompson DP, David B, Pina L, Gary JB, Mark AW, Bess HM, et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease. Circulation 2003;107(24):3109-16.

Faisal AW, Ayub M, Waseem T, Khan RS, Hasnain SS. Risk factors in young patients of acute myocardial infarction. J Ayub Med Coll Abbottabad 2011;23(3):10-3.

Ghosh JD, Dasgupta S, Rajni, Banerjee I, Biswas UK. Risk factor for acute myocardial infarction among rural population of Bihar: A community based study. Sch J Appl Med Sci 2014;2(3C):1075-80.

Vinay R, Prasannalakshmi R, Nikita C. Risk factors for acute myocardial infarction in Coastal region of India: A case–control study. Heart India 2014;2(3):70-5.

Roncaglioni MC, Santoro L, D’Avanzo B, Negri E, Nobili A, Ledda A, et al. Role of family history in patients with myocardial infarction. An Italian case-control study. GISSI-EFRIM investigators. Circulation 1992;85(6):2065-72.

Richard WN, Stuart Z. Acute myocardial infarction in diabetes mellitus. Circulation 1998;97(23):12-5.

Joseph DP, Robert LT, Gary CY, Gary RM. Pharmacotherapy. A Pathophyphysiologic Approach. 7th ed. United States of America. M. Graw Hill; 2008.

Howard PA, Ellerbeck EF. Optimizing beta-blocker use after myocardial infarction. Am Fam Physician 2000;62(8):1853-60, 1865-6.

Published

2016-12-01

How to Cite

Baby, L. P., N. Johnson, S. John, K. R, and S. R. “PROSPECTIVE OBSERVATIONAL STUDY ON MYOCARDIAL INFARCTION IN RELATIONSHIP WITH VARIOUS RISK FACTORS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 9, Dec. 2016, pp. 156-60, doi:10.22159/ajpcr.2016.v9s3.13735.

Issue

Section

Original Article(s)