EVALUATION OF THE GENOTOXICITY OF ESSENTIAL OIL FROM ORIGANUM COMPACTUM BENTH. IN HUMAN LYMPHOCYTES

  • Houda Sbayou Faculty of Sciences and Technologies, Hassan 1st University. Settat
  • Hayat Talbi Faculty of Sciences and Technologies, Hassan 1st University. Settat
  • Ibtissam Talha Faculty of Sciences and Technologies, Hassan 1st University. Settat
  • Souad Amghar Higher Normal School, Mohammed V University. Rabat
  • Abderraouf Hilali Faculty of Sciences and Technologies, Hassan 1st University. Settat

Abstract

ABSTRACT
Objective: Essential oils with antimicrobial and antioxidant activities have gained importance. This study was conducted to investigate the genotoxic
potential of the essential oil of Origanum compactum.
Methods: Micronucleus test and proliferation index (PI) were used to evaluate the genotoxic effect of the essential oil of O. compactum on human
lymphocytes.
Results: The results demonstrated that the PI values were influenced by the tested essential oil. An increase in concentration of essential oil also
caused the appearance of micronuclei.
Conclusion: The results of the present work suggest that O. compactum essential oil exhibited genotoxic activity at higher concentration. Further
studies are necessary to confirm these findings.
Keywords: Origanum compactum, Human lymphocytes, Proliferation index, Micronucleus test.

Author Biographies

Houda Sbayou, Faculty of Sciences and Technologies, Hassan 1st University. Settat
Laboratory of Agrofood and Health, Faculty of Sciences and Technolgies Hassan 1st University. Settat
Hayat Talbi, Faculty of Sciences and Technologies, Hassan 1st University. Settat
Laboratory of Agrofood and Health, Faculty of Sciences and Technolgies Hassan 1st University. Settat
Ibtissam Talha, Faculty of Sciences and Technologies, Hassan 1st University. Settat
Laboratory of Agrofood and Health, Faculty of Sciences and Technolgies Hassan 1st University. Settat
Souad Amghar, Higher Normal School, Mohammed V University. Rabat
Laboratory of Improved Soil and Productivity, Mohammed V University. Rabat
Abderraouf Hilali, Faculty of Sciences and Technologies, Hassan 1st University. Settat
Laboratory of Agrofood and Health, Faculty of Sciences and Technolgies Hassan 1st University. Settat

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How to Cite
Sbayou, H., H. Talbi, I. Talha, S. Amghar, and A. Hilali. “EVALUATION OF THE GENOTOXICITY OF ESSENTIAL OIL FROM ORIGANUM COMPACTUM BENTH. IN HUMAN LYMPHOCYTES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 8, Oct. 2016, pp. 274-6, doi:10.22159/ajpcr.2016.v9s2.13743.
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