PHYSICAL, CHEMICAL CHARACTERISTICS AND RELEASE RATE OF MELOXICAM FROM NANOSTRUCTURED LIPID CARRIERS (NLC) SYSTEM USING SOME CONCENTRATION RATIOS OF MONOSTEARIN AND ALPHA TOCOPHEROL ACETATE LIPID MATRIX

  • Yulia Anggraeni Post Graduated student of Airlangga University, Jalan Dharmawangsa Dalam, Surabaya, 60286, East Java
  • Isnaeni Isnaeni Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya, 60286, East Java
  • Esti Hendradi Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya, 60286, East Java

Abstract

Objective: The objective of this research is to develop nanostructured lipid carriers (NLC) of meloxicam (MLX) for topical application using monostearin and alpha-tocopherol as lipid matrix.

Methods: MLX-NLC was prepared by high-shear homogenization, and it was characterized for organoleptic, pH, viscosity, particle size and size distribution, zeta potential, crystallinity, morphology, and entrapment efficiency. The six different ratios of solid and liquid lipid matrix were

70:30, 75:25, 80:20, 85:15, 90:10, and 95:5, respectively.

Results: The pH value of all formulas met the pH range of topical dosage at 4.5-6.5. Viscosity test showed that a trend toward the decrease in viscosity with the increase in alpha-tocopherol content was observed. The results of particle size test proved that all six NLC system formulas have <1000 nm particle size with a quite narrow particle size distribution. Scanning electron microscope revealed nearly spherical shape NLC with negligible effect ratios of solid and liquid lipid on the particle morphology. The X-ray diffraction result showed the decreasing of peaks intensity of MLX-NLC system. It showed that MLX in NLC system is amorphous. The result showed that the increasing concentration of liquid lipid in NLC system caused the rising entrapment efficiency of MLX.

Conclusion: The result of this research indicates that the concentration ratio of monostearin and alpha-tocopherol acetate affects the physical and chemical characteristics of NLC system.

Keywords: Nanostructured lipid carriers, Meloxicam, Monostearin, Physical and chemical characteristics, Entrapment efficiency.

 

Author Biographies

Yulia Anggraeni, Post Graduated student of Airlangga University, Jalan Dharmawangsa Dalam, Surabaya, 60286, East Java

Post Graduated Student in Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University

Isnaeni Isnaeni, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya, 60286, East Java
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University
Esti Hendradi, Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya, 60286, East Java
Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University

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How to Cite
Anggraeni, Y., I. Isnaeni, and E. Hendradi. “PHYSICAL, CHEMICAL CHARACTERISTICS AND RELEASE RATE OF MELOXICAM FROM NANOSTRUCTURED LIPID CARRIERS (NLC) SYSTEM USING SOME CONCENTRATION RATIOS OF MONOSTEARIN AND ALPHA TOCOPHEROL ACETATE LIPID MATRIX”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 2, Feb. 2017, pp. 132-7, doi:10.22159/ajpcr.2017.v10i2.14806.
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