PHOSPHOLIPASE A 2 PLASMA ELASTASE ACTIVITY IN PRE AND POST PARTUM OF PRE-ECLAMPTIC WOMEN

  • Dayanand CD SRI DEVARAJ URS MEDICAL COLLEGE,SDUAHER
  • Vanishree Bambrana sRI DEVARAJ URS MEDICAL COLLEGE,SDUAHER
  • Sheela Sr sRI DEVARAJ URS MEDICAL COLLEGE,SDUAHER

Abstract

Objective: The objectives of the present study were to evaluate the activity of phospholipase A 2 , plasma elastase enzymes and to assess relation with
an inflammatory marker high sensitive C-reactive protein (hs-CRP) in nonpregnant before and after delivery of normotensive pregnant and preeclamptic
women.

Methods: The study population consists of three groups: Nonpregnant (Group 1, n=57), normotensive pregnant (Group 2, n=57), and pre-eclamptic
women (Group 3, n=57). Groups 2 and 3 were followed after delivery within 48 hrs. Phospholipase A , plasma elastase, and hs-CRP levels were determined spectrophotometrically.

Results: The plasma elastase, phospholipase A 22 activity, and hs-CRP were elevated in pre-eclampsia significantly (p<0.05), nonsignificant rise in
normotensive pregnant before delivery condition compared to nonpregnant women. However, plasma elastase in normal pregnancy and pre-eclampsia
were decreased by 1.2- and 2.07-fold, respectively, after delivery. Whereas phospholipase A and hs-CRP found to be nonsignificantly decreased in the
postdelivery status of the both the groups. Receiver operating characteristics curve analysis showed that elastase enzyme has diagnostic importance to assess inflammation on the basis of area under curve (0.758).2

Conclusion: Our research findings generated knowledge about raised level of plasma elastase enzyme by neutrophil degranulation represents inflammation in pre-eclampsia. Elevated elastase, phospholipase A

Keywords: Elastase, High sensitive C - reactive protein, Phospholipase A2
with hs-CRP in pre-eclampsia serves as indicators of inflammation., Pre-eclampsia.

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Objective:Theobjectivesofthepresentstudywere toevaluatetheactivityofphospholipaseA,plasmaelastaseenzymesand toassessrelationwith an inflammatorymarkerhighsensitiveC-reactiveprotein(hs-CRP)innonpregnantbeforeandafterdeliveryofnormotensivepregnantandpre- eclamptic women.

 

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Methods:Thestudypopulationconsistsofthreegroups:Nonpregnant(Group1,n=57),normotensivepregnant(Group2,n=57),andpre-eclamptic women(Group3,n=57).Groups2and3werefollowedafterdeliverywithin48hrs.PhospholipaseA,plasmaelastase,andhs-CRPlevelswere

determined spectrophotometrically.


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Results:Theplasmaelastase,phospholipaseA


 

activity,andhs-CRPwereelevatedinpre-eclampsiasignificantly(p<0.05),nonsignificantrisein


normotensivepregnantbeforedeliveryconditioncomparedtononpregnantwomen.However,plasmaelastaseinnormalpregnancyandpre-eclampsia

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weredecreasedby1.2-and2.07-fold,respectively,afterdelivery.WhereasphospholipaseA  andhs-CRPfoundtobenonsignificantlydecreasedinthe postdelivery status of the both the groups. Receiver operating characteristics curve analysis showed that elastase enzyme has diagnostic importance to assess inflammation on the basis of area under curve (0.758).

 

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Conclusion: Ourresearchfindingsgeneratedknowledgeaboutraisedlevelofplasmaelastaseenzymebyneutrophildegranulationrepresents inflammation in pre-eclampsia. Elevated elastase, phospholipase A  with hs-CRP in pre-eclampsia serves as indicators of inflammation.

2

 Keywords:Elastase, High sensitive C - reactive protein, Phospholipase A, Pre-eclampsia.

Author Biographies

Dayanand CD, SRI DEVARAJ URS MEDICAL COLLEGE,SDUAHER

Professor,

Department of Biochemistry

Vanishree Bambrana, sRI DEVARAJ URS MEDICAL COLLEGE,SDUAHER

Ph.D Scholar,

Department of Bicohemistry

Sheela Sr, sRI DEVARAJ URS MEDICAL COLLEGE,SDUAHER

Professor,

Department of Obsterics and Gynecology

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Dayanand CD, V. Bambrana, and S. Sr. “PHOSPHOLIPASE A 2 PLASMA ELASTASE ACTIVITY IN PRE AND POST PARTUM OF PRE-ECLAMPTIC WOMEN”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 1, Jan. 2017, pp. 317-20, doi:10.22159/ajpcr.2017.v10i1.15358.
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