In recent days, heterocycles and their derivatives have become strong reflection in medicinal research and pharmaceutical fields because of their practical pharmacological and biological activities. Organic compounds; mainly heterocyclic compounds are wealthy in natural world and contain extra value because their structural subunits are established in many natural products such as enzymes, vitamins, antibiotics, acids, and hormones. Thiazine nucleuses found in compounds have variety of pharmacological activities such as antitumor, antimicrobial, antibacterial, antifungal, antiviral, and anti-inflammatory. This review spotlight on the substituted thiazines with possible antimicrobial activities that are at the present in development.

Keywords: Antibacterial, Substituted thiazines, Antimicrobial agents.


Author Biography

Praveen Kumar Sharma, Lovely Professional University

Department of Chemistry

Assistant Professor


1. Sharma PK. Morpholinylbenzothiazine consider as bioactive compound. Der Pharm Lett 2016;8(4):86-90.
2. Kumar G, Sharma PK. Synthesis, spectral, energetic and reactivity properties of phenothiazines: Experimental and computational approach. J Chem Pharm Res 2015;7(11):462-73.
3. Sharma PK.Antimicrobial activities of substituted 2-aminobenzothiazoles. J Chem Pharm Res 2015;7(3):819-22.
4. Sharma PK. Synthesis and antimicrobial activities of substituted phenylthioureas. J Chem Pharm Res 2015;7(2):133-9.
5. Sharma PK. Synthesis and antimicrobial studies of fused hetero cycles pyrimidobenzothiazoles. J Chem Pharm Res 2015;7(1):710-4.
6. Sharma PK, Kumar M. Synthesis of bioactive substituted pyrazolylbenzothiazinones. Res Chem Intermed2015;41(9):6141-8.
7. Sharma PK, Kumar M. Synthesis and antimicrobial activity of 2H-pyrimido [2, 1-b] benzothiazol-2-ones. Res Chem Intermed 2010;36(8):985-93.
8. Sharma PK, Kumar M. One-pot, multicomponent sequential synthesis of benzothiazoloquinazolinones. Synth Commun 2010;40(16):2347-52.
9. Sharma PK, Kumar M. N-bridged bioactive heterocycles: Synthesis of 2-methyl-4H-pyrimido[2,1-b]benzothiazol-4-ones. Res Chem Intermed 2009;35:35-41.
10. Sharma PK, Kumar M. Regioselective one-pot synthesis of 5-chloro-3- methyl-8-trifluoromethyl-4H-1,4-benzothiazines. Hetrocycl Commun 2009;15(2):127-33.
11. Sharma PK, Kumar M. Synthesis of 2, 4-diaryl-2, 3-dihydro-1, 5-benzothiazepines. Hetrocycl Commun 2008;14(3):155-60.
12. Ali TE, El-Kazak AM. Synthesis and antimicrobial activity of some new 1, 3-thiazoles, 1, 3, 4-thiadiazoles, 1, 2, 4-triazoles. Eur J Chem
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15. Deshmukh R. Synthesis, structural study and biological evaluation of 1, 3-thiazine. Pelagia Res Library Der Chem Sin 2015;6(3):59-63.
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21. Gayathri B, Jacob CM. Microwave assisted synthesis of fluoro, chloro 2-substituted benzimidazole thiazine derivatives for antibacterial and analgesic activities. Int J Res Pharm Sci 2012;2(3):146-58.
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23. Valliappan R. Synthesis, characterization and biological studies of some 3, 5-diaryltetrahydro-N-ethoxycarbonyl-1, 4-thiazine-1, 1-dioxide. J Appl Chem 2013;2(2):137-42.
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26. Gahtori P, Ghosh SK. Design, synthesis and SAR exploration of hybrid 4-chlorophenylthiazolyl-s-triazine as potential antimicrobial agents. J Enzyme Inhib Med Chem 2012;27(2):281-93.
27. Govindan S. Synthesis, characterization and biological studies of some 3, 5-diaryl-tetrahydro-N-formyl-1, 4-thiazine-1, 1-dioxide. J Chem Pharm Res 2013;5(1):99-103.
28. Sharma PK, Kumar M, Vats S. Synthesis and antimicrobial activity of morpholinyl/piperazinylbenzothiazines. Med Chem Res 2012;21(8):2072-8.
29. Rathod AK. Microwave-assisted synthesis of some new benzothiazines derivatives and their antimicrobial activity. Int J Pharm Sci Rev Res 2013;18(2):47-9.
30. Didwagh SS, Piste PB, Burungale AS, Nalawade AM. Synthesis and antimicrobial evaluation of novel 3-(4, 6-diphenyl-6H-1,
3-thiazin-2-yl)-2-(4-methoxyphenyl) thiazolidin-4-one derivatives. J Appl Pharm Sci 2013;3(11):122.
31. Dabholkar VV, Karekar A, Shinde NB, Naik P. Novel Spiro oxazoles containing triazolothiadiazines, thiadiazines and thiazines - Synthesis, characterization and biological evaluation. J Chem Biol Phys Sci
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33. Sharma PK, Kaur G. Antibacterial, antifungal and antioxidant activities of substituted pyrazolylbenzothiazines. Der Pharm Lett 2016;8(11):79-82.
34. Sharma PK. Antibacterial, antifungal and antioxidant activities of substituted 4H-1, 4-benzothiazines. Der Pharm Chem 2016;8(11):156-9.
35. Maheshwari M. A review: Synthesis and medicinal importance of 1, 4-benzothiazine analogs. Asian J Pharm Clin Res 2015;8(2):41-6.
36. Naruka YS. Antimicrobial activity and characterization of seven synthetic for mamidine disulfide derivatives. Innov J Sci 2016;4(5):1-3.
37. Bhardwaj G. Antibacterial activity in different extracts of Lantana camara against enteropathogens. Innov J Sci 2015;3(1):4-5.
38. Maheshwari M. Synthesis and anti-microbial activity of 1-(6-nitro- 2h-benzo [b] [1,4] thiazine-3(4h)-ylidene) hydrazine-1, 1-dioxide derivatives. Int J Pharm Pharm Sci 2016;8(10):178-82.
39. Badrey MG. Synthesis and antibacterial activity of fused isoxazole derivatives using grinding method. Int J Pharm Pharm Sci
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How to Cite
Sharma, P. K., and R. Makkar. “A REVIEW: THIAZINES DERIVATIVES TREATED AS POTENTIAL ANTIMICROBIAL AGENTS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 1, Jan. 2017, pp. 43-46, doi:10.22159/ajpcr.2017.v10i1.115467.
Review Article(s)