A REVIEW: ANTIMICROBIAL AGENTS BASED ON NITROGEN AND SULFUR CONTAINING HETEROCYCLES

Abstract

At present, heterocyclic compounds and their derived forms have become strong reflection in medicinal research field because of their positive pharmacological and biological properties. Heterocycles are prosperous in nature and have expanded additional importance because their structural subunits are established in many natural products such as antibiotics, vitamins, and hormones. Thiazine moieties present in compounds have multiplicity of medicinal activities such as antihypertensive, antitumor, antimicrobial, antibacterial, anticoagulant, antifungal, anticancer, and antiviral. This review article mainly based on thiazines and their derivatives with potential antimicrobial activities that are at this time in advancement.

Keywords: Nitrogen, Sulfur heterocycles (thiazines), Antibacterial, Antifungal, Antimicrobial agents.

Author Biography

Praveen Kumar Sharma, Lovely Professional University

Department of Chemistry

Assistant Professor

References

1. Sharma PK. Morpholinylbenzothiazine consider as bioactive
compound. Der Pharm Lett 2016;8(4):86-90.
2. Kumar G, Sharma PK. Synthesis, spectral, energetic and reactivity
properties of phenothiazines: Experimental and computational
approach. J Chem Pharm Res 2015;7(11):462-73.
3. Sharma PK. Antimicrobial activities of substituted
2-aminobenzothiazoles. J Chem Pharm Res 2015;7(3):819-22.
4. Sharma PK. Synthesis and antimicrobial activities of substituted
phenylthioureas. J Chem Pharm Res 2015;7(2):133-9.
5. Sharma PK. Synthesis and antimicrobial studies of fused heterocycles
pyrimidobenzothiazoles. J Chem Pharm Res 2015;7(1):710-4.
6. Sharma PK, Kumar M. Synthesis of bioactive substituted
pyrazolylbenzothiazinones. Res Chem Intermed 2015;41(9):6141-8.
7. Sharma PK, Kumar M. Synthesis and antimicrobial activity of
2H-pyrimido [2, 1-b] benzothiazol-2-ones. Res Chem Intermed
2010;36(8):985-93.
8. Sharma PK, Kumar M. One-pot, Multicomponent sequential synthesis
of benzothiazoloquinazolinones. Synth Commun 2010;40(16):2347-52.
9. Sharma PK, Kumar M. N-bridged bioactive heterocycles: Synthesis of
2-methyl-4H-pyrimido[2,1-b]benzothiazol-4-ones Res Chem Intermed
2009;35:35-41.
10. Sharma PK, Kumar M. Regioselective one-pot synthesis of 5-chloro-3methyl-8-trifluoromethyl-4H-1,4-benzothiazines.
Hetrocycl
Commun
2009;15(2):127-33.
11. Sharma PK, Kumar M. Synthesis of 2,4-diaryl-2, 3-dihydro-1,
5-benzothiazepines, Hetrocycl Commun 2008;14(3):155-60.
12. Maheshwari M. A review: Synthesis and medicinal importance of
1,4-benzothiazine analogs, Asian J Pharm Clin Res 2015;8(2):41-6.
13. Naruka YS. Antimicrobial activity and characterization of seven
synthetic formamidine disulfide derivatives. Innov J Sci 2016;4(5):1-3.
14. Bhardwaj G. Antibacterial activity in different extracts of lantana
camara against enteropathogens. Innov J Sci 2015;3(1):4-5.
15. Maheshwari M. Synthesis and anti-microbial activity of 1-(6-nitro2h-benzo[b][1,4]thiazine-3(4h)-ylidene)hydrazine-1,1-dioxide

derivatives.
Int J Pharm Pharm Sci 2016;8(10):178-82.
16. Damanjit CS. Synthesis and biological evaluation of 1,3-thiazines- A
review. Pharmacophore 2013;4(3):70-88.
17. Yavari I, Hossaini Z. Ph
P-mediated one-pot synthesis of functionalized
3, 4-dihydro-2H-1, 3-thiazines from N, N′-dialkylthioureas and activated
acetylenes in water. Monatsh Chem Chem Mon 2010;141(2):229-32.
3
18. Bhangale LP, Wadekar JB. Topliss modified approach for design
and synthesis of 1, 3-thiazines as antimicrobials. Int J Drug Des Dis
2011;2(4):637-41.
19. Thanusu J, Gopalakrishnan M. Synthesis, spectral characterization, and
in vitro antibacterial and antifungal activities of novel 1, 3-thiazine-2amines
comprising morpholine nucleus. J Enzyme Inhib Med Chem
2010;25(6):756-64.
20. Suresh CH, Jayaveera KN. Synthesis of 4-(2′-substituted
benzothiazoles)-5-mercapto-3-(substituted)-1, 2, 4-traizole derivatives
for possible antimicrobiological activities. Res J Pharm Biol Chem Sci
2010;1(4):635-40.
21. Abbas EM Farghaly TA. Synthesis, reactions, and biological activity
of 1, 4- benzothiazine derivatives. Monatsh Chem Chem Mon
2010;141(6):661-7.
22. Jupudi S, Rao PV. An overview on versatile molecule: 1, 3-thiazines.
Asian J Res Pharm Sci 2013;3(4):170-7.
23. Dipansu GS, Mander BP. Synthesis, characterization and biological
evaluation of some novel 4, 6-disubstituted-1, 3-thiaizne derivatives for
their antibacterial activity. Int J Health Pharm Sci 2012;1(1):27-33.
24. Naushad E, Panugonda R. Synthesis of N-nitroso-2, 6-dicarboxy-3,
5 diaryltetrahydro-1, 4 thiazine-1, 1 dioxides. Med Chem Res
2012;21:2056-63.
25. Varalakshmi D., Ramesh GP. Ramkrishna G. Synthesis and
biological evaluation of different Thiazine derivatives. J Pharm Res
2011;4(1):274-5.
26. Ram SG, Parhate VV. Synthesis, charecterization and antibacterial
activities of some new Bromo/Nitro 1, 3-thiazines. Rasayan J Chem
2013;6:65-7.
27. Sharma PK, Fogla A. Synthesis and antimicrobial activity of structurally
flexible heterocycles with the 1, 4-thiazine heterosystem. Res Chem
Intermed 2011;37(8):1103-11.
28. Sharma PK. Antifungal, antibacterial and antioxidant activities
of substituted morpholinylbenzothiazine. Der Pharm Lett
2016;8(11):140-2.
29. Sharma PK. Antibacterial, antifungal and antioxidant activities of
substituted pyrazolylbenzothiazines. Der Pharm Lett 2016;8(11):79-82.
30. Sharma PK. Antibacterial, antifungal and antioxidant activities of
substituted 4H-1,4-benzothiazines. Der Pharm Chem 2016;8(11):156-9.
31. Didwagh SS, Piste PB. Green synthesis of thiazine and oxazine
derivatives- A short review. Int J Pharm Sci Res 2013;4(6):20-45.
32. Elarfi MJ, Al-Difa HA. Synthesis of oxazine, thiazine and isoxazole and
their antibacterial activities. Sci Rev Chem Commun 2012;2(2):103-7.
33. Prakash N, Ingarsal N. A novel bromonaphthyl based 2-amino-1,
3-thiazines: Synthesis, characterization with in vitro antimicrobial
screening research. J Chem Sci 2015;5(7):8-11.
34. Rathore MM, Rajput, PR. Synthesis and antimicrobial activities of
some bromo-substituted-1, 3-thiazines. Int J Res Pharm Biomed Sci
2013;4:59-62.
Statistics
726 Views | 1027 Downloads
How to Cite
Sharma, P. K. “A REVIEW: ANTIMICROBIAL AGENTS BASED ON NITROGEN AND SULFUR CONTAINING HETEROCYCLES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 2, Feb. 2017, pp. 47-49, doi:10.22159/ajpcr.2017.v10i2.15673.
Section
Review Article(s)