PROTECTIVE EFFECT OF BEE PROPOLIS AGAINST ANTI-TUBERCULOSIS DRUGS (RIFAMPICIN AND ISONIAZID)-INDUCED HEMATOLOGICAL TOXICITY IN SPRAGUE DAWLEY RATS


Umesh Bharti, Neelima R Kumar, Jaspreet Kaur

Abstract


ABSTRACT
Objective: Protective effect of bee propolis against anti-tuberculosis (TB) drugs (rifampicin and isoniazid)-induced hematological toxicity in Sprague
Dawley (SD) rats.
Methods: Experimental male SD rats weighing 180±20 g were randomly assigned into eight groups (n=6), the Group 1 served as control; Group 2
received 200 mg bee propolis/kg body weight; Groups 3, 5, and 7 were treated with drugs 100 mg rifampicin/kg body weight, 50 mg isoniazid/kg
body weight, and 100 mg rifampicin+50 mg isoniazid/kg body weight, respectively. Groups 4, 6, and 8 were treatment groups receiving 200 mg bee
propolis/kg body weight+100 mg rifampicin/kg body weight, 200 mg bee propolis/kg body weight+50 mg isoniazid/kg body weight, and 200 mg bee
propolis/kg body weight+100 mg rifampicin+50 mg isoniazid/kg body weight, respectively. All the treatments were given for 30 days, and then, the
rats were sacrificed under light esthesia by cervical dislocation and blood was collected for physiological studies.
Results: Bee propolis supplementation (200 mg/kg body weight) showed increased level of hemoglobin with respect to rifampicin (15.45%),
isoniazid (11.34%), and rifampicin plus isoniazid (5.04%) administered groups after 30 days of treatment. Moreover, the decreased level of red blood
cell count and white blood cell count by anti-TB drugs rifampicin, isoniazid, and rifampicin plus isoniazid together was also elevated in treatment
group with bee propolis.
Conclusion: Coadministration of propolis (200 mg bee propolis/kg body weight) with drugs helped modulate the toxic effects by restoring tested
values to near normal.
Keywords: Propolis, Rifampicin, Isoniazid, Hemoglobin, Red blood cell count, White blood cell count.


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About this article

Title

PROTECTIVE EFFECT OF BEE PROPOLIS AGAINST ANTI-TUBERCULOSIS DRUGS (RIFAMPICIN AND ISONIAZID)-INDUCED HEMATOLOGICAL TOXICITY IN SPRAGUE DAWLEY RATS

DOI

10.22159/ajpcr.2017.v10i3.15991

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 3 March 2017 Page: 188-190

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

54 Views | 122 Downloads

Authors & Affiliations

Umesh Bharti
pggcg-11,panjab university, chandigarh
India

Neelima R Kumar
professor, Department of Zoology, Panjab university, Chandigarh, India
India

Jaspreet Kaur
UIET,Panjab university
India


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