STUDY OF PERFORMANCE CHARACTERISTICS OF TSH ON FINECARE™ POCT DEVICE

Authors

  • JASPREET KAUR Department of Biochemistry, Noida International Institute of Medical Sciences, Gautam Buddha Nagar, Uttar Pradesh, India. https://orcid.org/0000-0002-7491-0061
  • MITHILESH KUMAR SINGH Department of Biochemistry, Noida International Institute of Medical Sciences, Gautam Buddha Nagar, Uttar Pradesh, India.
  • AMIT SAMADHIYA Department of Biochemistry, Noida International Institute of Medical Sciences, Gautam Buddha Nagar, Uttar Pradesh, India.
  • GITANJALI GUPTA Department of Biochemistry, Noida International Institute of Medical Sciences, Gautam Buddha Nagar, Uttar Pradesh, India.
  • RENU CHANE Department of Biochemistry, Noida International Institute of Medical Sciences, Gautam Buddha Nagar, Uttar Pradesh, India.
  • JASWANT KAUR Department of Biochemistry, NC Medical College and Hospital, Panipat, Haryana, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i3.46724

Keywords:

Immunofluorescence assay, Preliminary evaluation, Final evaluation, TSH

Abstract

Objective: Thyroid diseases can be diagnosed and monitored by serum thyroid stimulating hormone (TSH) measurement along with serum T3 and T4 (both free and total). However, TSH is used to distinguish between euthyroid and hyperthyroid patients. Hence, analysis sensitivity of the TSH assay plays a very significant role. Aims and objectives – The aim of the study was to perform the precision study, calculate the randomerror and analytical measurement rangeverification, as well as verify the accuracy of TSH estimation on Finecare™ point of care testing (POCT).

Methods: The experimental evaluation was done in preliminary and final parts. The preliminary part calculates random errors, systemic errors, and recovery whereas the final evaluation comprises the implementation of the method comparison between chemiluminescence and immunofluorescence assay (CLIA).

Results: In the preliminary evaluation, the inter-assay-high-value sample had CV% was 15 whereas the low-value sample has 13, and the intra-assay had a CV% of 5.8. The recovery test shows 22.22% CV. The final evaluation of the new method Immuno Fluorescence Assay and reference method (CLIA) has a correlation of coefficient 0.9937.

Conclusion: POCT reduces pre-analytical error by reducing misidentification of the patient, specimen, and sample handling. This reduces the turn-around time. It helps to improve the quality of care, healthy outcomes, and affordability.

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References

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Published

07-03-2023

How to Cite

KAUR, J., M. K. SINGH, A. SAMADHIYA, G. GUPTA, R. CHANE, and J. KAUR. “STUDY OF PERFORMANCE CHARACTERISTICS OF TSH ON FINECARE™ POCT DEVICE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 3, Mar. 2023, pp. 48-51, doi:10.22159/ajpcr.2023.v16i3.46724.

Issue

Vol 16 Issue 3 March 2023

Section

Original Article(s)

Copyright (c) 2022 jaswant kaur jaswant kaur, Jaspreet Kaur

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This work is licensed under a Creative Commons Attribution 4.0 International License.

The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.

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