ECHINOCANDINS VERSUS DATED ANTIFUNGALS IN COMBINATION AGAINST OPPORTUNISTIC MYCOTIC INFECTIONS


Mrridula Dangi Narwal, Meenakshi Balhara, Renu Chaudhary, Chhillar Ak

Abstract


Scientific and clinical reports globally demonstrated that the opportunistic mycotic infections are at major risk to the human fitness. In past few decades, development of resistance in microbes to existing antifungals, has emphasized on the search of new antimycotic drugs. As a matter of fact "echinocandins" are new categories of broad-spectrum antifungal enlighten a hope in this direction. Echinocandins are bulky lipopeptides that inhibits the production of β-[1,3]-glucan "a major constituent of fungal cell wall" which ultimately leads to the death of fungal pathogens. In vitro as well as in vivo published reports have demonstrated that the echinocandins exhibit fungicidal activity against most Candida spp while fungistatic against Aspergillus spp and exclusively found to be more effective when tested in combination with polyenes/azoles. Present article is an expert views on the recent and historical literature available on the antifungal therapies with accessing their impact on the human health. Emphasis is given on the utility of the echinocandins as potential antifungal agent by discussing recent examples of clinical and laboratory studies including the use of improved proteomics approaches to know a bit more about the interaction of human host and fungal pathogens.


Keywords


Echinocandins, Antifungal, Aspergillus, Candida, Opportunistic, Combination.

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References


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About this article

Title

ECHINOCANDINS VERSUS DATED ANTIFUNGALS IN COMBINATION AGAINST OPPORTUNISTIC MYCOTIC INFECTIONS

Keywords

Echinocandins, Antifungal, Aspergillus, Candida, Opportunistic, Combination.

DOI

10.22159/ajpcr.2017.v10i8.17186

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 8 August 2017 Page: 54-59

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

179 Views | 134 Downloads

Authors & Affiliations

Mrridula Dangi Narwal
Department of Biotechnology , Centre for Biotechnology, M.D. University, Rohtak, Haryana, India.
India

Meenakshi Balhara
Department of Biotechnology , Centre for Biotechnology, M.D. University, Rohtak, Haryana, India.
India

Renu Chaudhary
Department of Biotechnology , Centre for Biotechnology, M.D. University, Rohtak, Haryana, India.

Chhillar Ak
Department of Biotechnology , Centre for Biotechnology, M.D. University, Rohtak, Haryana, India.
India


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