PYRAZOLINES AS POTENT ANTITUBERCULAR AND CYTOTOXIC AGENTS


Ishwar Bhat K, Abhishek Kumar

Abstract


Objective: Pyrazolines are known to exhibit different biological and pharmacological properties such as anticancer, antibacterial, antifungal and antitubercular activities. Chalcones with an enone group between two aromatic rings exhibit remarkable pharmacological activities such as antiinflammatory, antibacterial, antitumor, antifungal, and antimalarial activity. A series of pyrazolines from chalcones have been synthesized and evaluated for antitubercular and cytotoxic activity studies.

Methods: Chalcones [3-substituted phenyl-1-(p-tolyl)prop-2-en-1-one] were synthesized from various substituted aldehydes and 4-methyl acetophenone and cyclized into pyrazolines [5-substituted phenyl-3-(p-tolyl)-4,5-dihydro-1H-pyrazole] using hydrazine hydrate. Antitubercular and cytotoxic activity studies were carried out.

Results: Antitubercular and cytotoxic activity studies of synthesized pyrazoline revealed that some compounds have showed promising activity.

Conclusion: The observed results proved that pyrazolines are found to be interesting lead molecules for further synthesis as antitubercular and cytotoxic agents.


Keywords


Chalcones, Pyrazoline, Antitubercular activity, Cytotoxic activity.

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About this article

Title

PYRAZOLINES AS POTENT ANTITUBERCULAR AND CYTOTOXIC AGENTS

Keywords

Chalcones, Pyrazoline, Antitubercular activity, Cytotoxic activity.

DOI

10.22159/ajpcr.2017.v10i6.17344

Date

01-06-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 6 June 2017 Page: 247-249

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

53 Views | 66 Downloads

Authors & Affiliations

Ishwar Bhat K
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, India.
India

Abhishek Kumar
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, India.
India


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