NIGELLA SATIVA HAS BENEFICIAL EFFECT ON OSTEOPOROSIS AND BONE HEALING. IS IT FACT OR FICTION? A SYSTEMATIC REVIEW
Osteoporosis is the most common reason for a broken bone among the elderly. Several experimental studies have been reported that Nigella sativa
(NS) and/or its major component thymoquinone (TQ) have good effects on osteoporosis and bone healing. We conducted this systematic review to
evaluate these relevant studies to prove whether NS and/or TQ has potential effect on osteoporosis and can stop pathogenesis of this disease or this
matter still just a fiction. A search on published studies was done using databases including Scopus, PubMed, Google Scholar, Web of Science, and
CINAHIL. Terms searched included â€œNigella sativa, black seed, TQ, osteoporosis, bone healing.â€ Initially, 213 articles were extracted. After reviewing their titles and abstracts, 124 articles (Medline, 43; Scopus, 67; EBSCO, 14) were retrieved for further evaluation. However, after excluding the clinical trial studies, human reviews, removal of abstracts and unrelated studies, seven studies were considered finally as eligible for our review. Finally, seven studies were considered eligible for our review. The total number of animals used was 220 (150 rats and 70 rabbits) from different experimental study. Based on the results of this systematic review, we conclude that NS or TQ extract therapy for osteoporosis cannot be recommended yet and these data will not suffice to exclude the beneficial effects of NS on bone turnover reliably. Therefore, more studies are required to explore the specific cellular and molecular targets of NS or TQ using animal osteoporosis models. Once the anti-osteoporotic effectiveness of NS or TQ will be established, human studies can be carried out.
2. Raisz LG. Pathogenesis of osteoporosis: Concepts, conflicts, and prospects. J Clin Invest 2005;115(12):3318-25.
3. Ebeling PR, Daly RM, Kerr DA, Kimlin MG. Building healthy bones throughout life: An evidence-informed strategy to prevent osteoporosis in Australia. Med J Aust 2013;199 7 Suppl: S1.
4. Body JJ. How to manage postmenopausal osteoporosis? Acta Clin Belg 2011;66(6):443-7.
5. Drugs for postmenopausal osteoporosis. Med Lett Drugs Ther 2014;56(1452):91-6.
6. Bolland MJ, Leung W, Tai V, Bastin S, Gamble GD, Grey A, et al. Calcium intake and risk of fracture: Systematic review. BMJ 2015;351:h4580.
7. Avenell A, Mak JC, Oâ€™Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev 2014;4:CD000227.
8. Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed 2013;3(5):337-52.
9. Hmza AJ, Osman MT, Adnan A, Omar E. Immunomodulatory effect of Nigella sativa oil in the disease process of Type 1 diabetic rats. Res J Pharm Biol Chem Sci 2013;4(1):980-8.
10. Hmza AJ, Omar E, Adnan A, Osman MT. Nigella sativa oil has significant repairing ability of damaged pancreatic tissue occurs in induced Type 1 diabetes mellitus. Glob J Pharmacol 2013;7(1):14-9.
11. Goreja WG. Black Seed: Natureâ€™s Miracle Remedy. New York, NY: Amazing Herbs Press; 2003.
12. Abdel-Sater KA. Gastroprotective effects of Nigella sativa oil on the formation of stress gastritis in hypothyroidal rats. Int J Physiol Pathophysiol Pharmacol 2009;1(2):143-9.
13. Assayed ME. Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. Immunopharmacol Immunotoxicol 2010;32(2):284-96.
14. Al-Ali A, Alkhawajah AA, Randhawa MA, Shaikh NA. Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. J Ayub Med Coll Abbottabad 2008;20(2):25-7.
15. Shady AM, Nooh HZ. Effect of black seed (Nigella sativa) on compact bone of streptozotocin induced diabetic rats. Egypt J Histol 2010;33(1):168-77.
16. Seif AA. Nigella sativa reverses osteoporosis in ovariectomized rats. BMC Complement Altern Med 2014;14:22.
17. Kara MI, Erciyas K, Altan AB, Ozkut M, Ay S, Inan S. Thymoquinone accelerates new bone formation in the rapid maxillary expansion procedure. Arch Oral Biol 2012;57(4):357-63.
18. Arslan AH, Tomruk CO, MeydanlI EG, Ã–zdemir I, Ã‡apar GD, KÃ¼tan E, et al. Histopathological evaluation of the effect of systemic thymoquinone administration on healing of bone defects in rat tibia. Biotechnol Biotechnol Equip 2017;31(1):175-81.
19. Al-Enazi MM. Thymoquinone attenuates ovariectomy induced alteration in bone architecture and metabolism in rats. Asian J Med Sci 2015;7(1):8-16.
20. Al-Saâ€™aidi JA, Dawoodand KA, Latif AD. Immunomodulatory effect of Nigella sativa seed extract in male rabbits treated with dexamethasone. Iraqi J Vet Sci 2012;26 Suppl IV:141-9.
21. Al-Mutheffer EA. The percutaneous effect of black seed (Nigella sativa) oil as external topical treatment on bone healing in rabbits. AL-Qadisiya J Vet Med Sci 2014;13(2):146-54.
22. Kanter M. Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochem Res 2008;33(1):87-96.
23. Mattix Kramer HJ, Grodstein F, Stampfer MJ, Curhan GC. Menopause and postmenopausal hormone use and risk of incident kidney stones. J Am Soc Nephrol 2003;14(5):1272-7.
24. Maggio D, Barabani M, Pierandrei M, Polidori MC, Catani M, Mecocci P, et al. Marked decrease in plasma antioxidants in aged osteoporotic women: Results of a cross-sectional study. J Clin Endocrinol Metab 2003;88(4):1523-7.
25. Basu S, MichaÃ«lsson K, Olofsson H, Johansson S, Melhus H. Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 2001;288(1):275-9.
26. Christensen JO, Svendsen OL. Bone mineral in pre- and postmenopausal women with insulin-dependent and non-insulin-dependent diabetes mellitus. Osteoporos Int 1999;10(4):307-11.
27. Osman MT, Adnan A, Bakar NS, Alashkham F. The potential immunomodulatory effect of allicin administration in autommune disease process of Type 1 diabetes mellitus. Int J Pharm Pharm Sci 2012;4 Suppl 5:440-4.
28. Patil US, Jaydeokar AV, Bandawane DD. Immunomodulators: A pharmacological review. Int J Pharm Pharm Sci 2012;4(1):30-6.
29. Law MR, Hackshaw AK. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: Recognition of a major effect. BMJ 1997;315(112):841-6.
30. Ahmad NS, Khalid BA, Luke DA, Ima Nirwana S. Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone. Clin Exp Pharmacol Physiol 2005;32(9):761-70.
31. Ebina Y, Okada S, Hamazaki S, Toda Y, Midorikawa O. Impairment of bone formation with aluminum and ferric nitrilotriacetate complexes. Calcif Tissue Int 1991;48(1):28-36.
32. Akhtar M, Maikiyo AM, Khanam R, Mujeeb M, Aqil M, Najmi AK. Ameliorating effects of two extracts of Nigella sativa in middle cerebral artery occluded rat. J Pharm Bioallied Sci 2012;4(1):70-5.
33. Piattelli A, Piattelli M, Mangano C, Scarano AA. Histological evaluation of eight cases of failed dental implants: Is bone over heating the most predictable cause. J Biomater 1998;19:683-90.
34. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995;61(1):33-6.
35. Steimbach LM, Loucao AD, Carraro CB, Tonin FS, Pontarolo R, Sanches AC. Metformin usage to induce ovulation in women with polycystic ovary syndrome: A meta analysis. Int J Pharm Pharm Sci 2016;8(11):86-9.
36. Shuid AN, Mohamed N, Mohamed IN, Othman F, Suhaimi F, Ramli ES, et al. Nigella sativa: A potential antiosteoporotic agent. Evi Based Complement Alternat Med 2012;2012:Article ID: 696230.
37. Tembhurne SV, Feroz S, More BH, Sakarkar M. A review on therapeutic potential of Nigella sativa (Kalonji) seeds. J Med Plants Res 2014;8(3):167-77.
38. Rajagopal PL, Amrutha C, Premaletha K, Premkumar N. Medicinal plants in osteoporosis - A review. Int J Adv Pharm Biol Chem 2013;2(4):605-8.
39. Ansari R, Gheek N. Effects of Nigella sativa against osteoporosis. Int J Pure Appl Biosci 2013;1(2):6-14.
40. Valizadeh N, Zakeri HR, Asnafi GA, Shafiee A, Sarkhail P, Heshmat R, et al. Impact of black seed (Nigella sativa) extract on bone turnover markers in postmenopausal women with osteoporosis. DARU J Pharm Sci 2009;17 Suppl 1:20-5.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.