ANTIMICROBIAL AND ANTHELMINTIC ACTIVITIES OF SOME NEWLY SYNTHESIZED TRIAZOLES


Jeetendra Kumar Gupta, Pradeep Mishra

Abstract


Objective: The objective of this work is to synthesize and evaluate some novel 1,2,4-triazoles.

Methods: Procedure includes synthesis of triazole compounds followed by biological evaluations. The synthesis was carried out in six steps withp-bromobenzoic acid as starting material and converting to ester and then to hydrazide. Hydrazide was then converted to 4-amino triazole. Theamino triazole was then linked to different secondary amines using chloroacetyl chloride as the linking agent. All the synthesized compounds werecharacterized through Fourier transform infrared spectroscopy, gas chromatography-mass spectroscopy, and nuclear magnetic resonance. Further,the compounds were taken out for biological evaluations. To explore their effects, experiments were conducted on various micro- as well as macroorganisms.The toxicityprofilewasalso testedin accordancewith OECD 425 guideline on Wistar albino rats.

Results: The compounds were examined for antibacterial as well as antifungal activities. Among the all compound T71, T73, and T75 exhibitedantibacterial activity, and compound T71 showed antifungal activity as well. The evaluation was also carried out for anthelmintic activities. Thecompounds were treated on Pheretima posthuma at various concentrations to explore their vermifuge and vermicidal action. The triazole linked with1-methylpiperazine was found to have comparable activity to that of reference standards.

Conclusion: Triazoles are a most potent assemblage of fungal retardants. But depending on their substituents, they also have diverse pharmacologicalvalues. In this study, the compound T71 showed promising antimicrobial as well as anthelmintic action. Hence, it can be considered as a lead compoundfor further researches.


Keywords


Anthelmintic, Antimicrobial, Triazole, Piperazine, Albendazole.

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References


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About this article

Title

ANTIMICROBIAL AND ANTHELMINTIC ACTIVITIES OF SOME NEWLY SYNTHESIZED TRIAZOLES

Keywords

Anthelmintic, Antimicrobial, Triazole, Piperazine, Albendazole.

DOI

10.22159/ajpcr.2017.v10i6.17800

Date

01-06-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 6 June 2017 Page: 139-145

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

63 Views | 14 Downloads

Authors & Affiliations

Jeetendra Kumar Gupta
Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura - 281 406, Uttar Prasesh, India.
India

Pradeep Mishra
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura - 281 406, Uttar Pradesh, India.
India


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