FORMULATION AND PHYSICAL CHARACTERISTICS OF DETAM II SOYBEAN (GLYCINE MAX (L.) MERR) TABLET WITH VARIOUS CONCENTRATION OF SILICON DIOXIDE AND MAGNESIUM STEARATE
Objective: This research was conducted to obtain several formulation and evaluate the physical characteristics of the soybean Glycine max (L.) Merr Detam II variety tablets.
Methods: Detam II varieties of soybean (G. max (L.) Merr.) were cleaned and grinded into 30 mesh-sized powder. Weighed soybean powder and internal phase of excipients (based on the formula) mixed by a Y-cone mixer until homogeneous, and then continue with dry granulation process. Granules formed, then sieved into 16 mesh size, and then, the characteristics examined. Dried granules then mixed with magnesium stearate and silicon dioxide using a drum mixer and compressed into tablets. Physical characteristics of tablets measured at 0, 4, 7, 14, 21, and 28 days.
Results: Evaluation was done for particle size distribution, moisture content (MC), flow properties, weight uniformity, friability, hardness, and disintegration time. Dry granulation was the best method to improve the characteristics of soybean powder with poor compressibility, poor flowability, and hygroscopic. Flow properties of the granules became better for Formula II and III by adding the concentration of silicon dioxide. The formulas also showed the good uniformity of weight, size, MC, friability, and disintegration time. Reducing the lubricant until 0, 5% of the formula made differences in friability, hardness, and disintegration time better than another formula.
Conclusion: The result of this research indicates that differences in silicon dioxide and magnesium stearate composition of the formula can affect the physical characteristics of soybean (G. max (L.) Merr.) tablets.
2. Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci 2008;4:89-90.
3. Yulia R, Christyaningsih J, Irmasari V. The antioxidant substances profile of Glycine max L. merr. var. Detam II ultrasonic extract. Res J Pharm Biol Chem Sci 2015;6:502-8.
4. Astuti S. Isoflavon kedelai dan potensinya sebagai penangkap radikal bebas. J Teknol Ind Hasil Pertanian 2008;13:127-31.
5. Pavithra S, Manibala J, Ramachandran J. Evaluation of in-vitro antioxidant and fibrinolytic activity of flavonoid-rich fraction from the whole plant of wedelia Chinensis. Asian J Pharm Clin Res 2016;9:234-9.
6. Sen S, Chakraborty R, Sridhar C, Reddy YS, De B. Free radicals, antioxidants, diseases and phytomedicines: Current status and future prospect. Int J Pharm Sci Rev Res 2010;3:94.
7. Christyaningsih J, Yulia R. The effects Gycine max L. Merr on Lipid peroxidation and kidneyâ€™s histopathology in lead intoxication mice. Res
J Pharm Biol Chem Sci 2015;6:1204-10.
8. Jeong JH, Jo YN, Kim JH, Eun JD, Dae-Ok K, Jin HH. Black soybean extract protects against TMT-induced cognitive defects in mice. J Med Food 2014;17:83.
9. Xu BJ, Chang SK. A comparative study on phenolic profiles and antioxidant of legumes as affected by extraction solvents. J Food Sci 2007;72:159-66.
10. Salih OS, Nief RA. Effect of natural and synthetic polymers on the properties of candesartan cilexetil matrix tablet prepared by dry granulation. Asian J Pharm Clin Res 2016;9:161-70.
11. Qiu YH, Chen YS, Zhang GG, Yu L, Mantri RV. Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice. London: Elsevier; 2017 209,561.
12. Departemen Kesehatan Republik Indonesia. Direktorat Jenderal Pengawas Obat dan Makanan, Farmakope Indonesia V. Jakarta: Departemen Kesehatan Indonesia; 2014.
13. Troy DB. Remington: The Science and Practice of Pharmacy. 21st ed. Baltimore: Lippincott Williams & Wilkins; 2006. p. 893, 916-7.
14. Hadisoewigyo L, Fudholi A. Sediaan Solida. Yogyakarta: Pustaka Pelajar; 2013.
15. United States Pharmacopeia (USP). The United State Pharmacopoeial Convention. 37th ed. United States: The United States Pharmacopeia (USP); 2014.