GENETIC DISORDER ALZHEIMER


Pratibha Rani, Kamaldeep Singh, Anania Arjuna, Savita Devi

Abstract


Alzheimer’s disease (AD), slowly continuous neurological disorder, mostly appears in older >65 age that deals with the memory loss due to death or damage of brain cells and cognitive functions (thinking, reasoning, and behavior abnormalities) due to the accumulation of the specific protein (beta-amyloid protein) which form plaque and fibers (tau tangles) in the brain. Not only the genetic factors are responsible but also most of the non-genetic factors are responsible for AD. Several mutations in the gene (APP, APOE, PENS1, PENS2 on chromosome no. 21, 19, 14, 1) are responsible for causing four types of AD. Memory loss is most common sign of AD. Predisposing factors of AD are hereditary, severe brain injury or traumatic, and metabolic diseases such as diabetes mellitus, hypercholesteremia, and obesity. Although treatment can manage some symptoms in few people, but there is no current mechanism to cure AD or stop its progression. Beta-secretase inhibitor molecule prevents the first step in a chain accumulation which leads to the formation of amyloid plaque in the brain. However, the scientist or researchers have established a compound NIC5-15 they have been found NIC5-15 has safe and effectual treatment which has been used to stabilize cognitive performance in patients with mild to moderate AD.


Keywords


Alzheimer’s disease, Beta-amyloid protein, Memory loss, Hypercholesteremia.

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About this article

Title

GENETIC DISORDER ALZHEIMER

Keywords

Alzheimer’s disease, Beta-amyloid protein, Memory loss, Hypercholesteremia.

DOI

10.22159/ajpcr.2017.v10i12.18684

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 36-39

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

13 Views | 40 Downloads

Authors & Affiliations

Pratibha Rani
Department of Medical Laboratory Sciences, C.T Group of Institute, Shahpur, Jalandhar, Punjab, India.
India

Kamaldeep Singh
Deparatment of Medical Laboratory Sciences, Lovely Professional University, Phagwara – 144 411, Punjab, India.
India

Anania Arjuna
Department of Medical Laboratory Sciences, C.T Group of Institute, Shahpur, Jalandhar, Punjab, India.
India

Savita Devi
Department of Medical Laboratory Sciences, C.T Group of Institute, Shahpur, Jalandhar, Punjab, India.
India


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