CORRELATION OF BODY MASS INDEX WITH THYROID-STIMULATING HORMONES IN THYROID PATIENT

  • Anupam Sharma Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara - 144411, Punjab, India.
  • Savita Devi Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara - 144411, Punjab, India.
  • Kamaldeep Singh Department of Medical Laboratory Sciences and Biotechnology, CT Group of Institute, Shahpur, Jalandhar, Punjab, India.
  • Pranav Kumar Prabhakar Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara - 144411, Punjab, India.

Abstract

Objective: The present study was investigated to determine the correlation of body mass index (BMI) with thyroid-stimulating hormones (TSH) in thyroid patient.

Methods: The data which are used in this study were taken in Tagore Hospital and Heart Care Centre (Jalandhar). A total of 90 volunteers both males and females in the age group between 17 and 85 years were included in this study. The following information taken on pro forma such as age in years, height (cm), weight (kg), and history (including: Chief complaints, family thyroid history, blood pressure, temperature, and head and neck examination) from the subjects were collected. Serum T3, T4 and TSH test are performed by the use of instrument ADVIA Centaur@CP Immunoassay System (SIEMENS). The total data were divided into three groups named as: Subclinical hypothyroid (SH) (n=30), euthyroid (n=57), and hyperthyroid including only three patients, and according to age, weight (kg), height (m2), and BMI, the mean±standard deviation (S.D) values were calculated. The BMI is calculated with the formula given by the WHO.

Results: For correlation analysis, according to total male and female population in euthyroid group, the mean and SD values of TSH and BMI were calculated. Maximum values of T3 (4.7) and T4 (22.1) in hyperthyroid and TSH (9.9) in SH group were found. The high mean values of T3 (2.92) and T4 (18.46) in hyperthyroid and TSH (29.1) in SH group were observed. Low mean values of T3 (0.97) and T4 (7.7) in SH and low mean TSH (0.04) in hypothyroid group were noticed.

Conclusion: Based on the data analysis, it can interpreted that a poor positive correlation between TSH and BMI and poor negative correlation between TSH and BMI are associated in euthyroid subjects. It indicates that, when TSH increases, the BMI will also be increased in total and female euthyroid subjects.

Keywords: Thyroid hormones, Thyroiditis, Hypothyroidism, Euthyroid, Subclinical hypothyroidism

References

1. Tortora GJ, Derrickson BH. Principles of Anatomy and Physiology. 12th ed., Vol. 1. Hoboken, NJ: John Wiley & Sons; 2009. p. 658-9.
2. Peeters RP. Regulation of Thyroid Hormone Bioactivity in Health and Disease; 2005.
3. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, et al. Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management. J Am Med Assoc 2004;291:228-38.
4. Surks MI, Schadlow AR, Stock JM, Oppenheimer JH. Determination of iodothyronine absorption and conversion of L-thyroxine (T4) to L-triiodothyronine (T3) using turnover rate techniques. J Clin Invest 1973;52:805-11.
5. Koumourou R, Hanner R. Running on Empty Hypothyroidism; Introduction to an Underactive Thyroid Gland. Dandenong, Australia: GN & EJ Ridgway; 2004. p. 41-2.
6. Brent GA, Koenig RJ. Thyroid and antithyroid drugs. In: Brunton L, Chabner B, Knollman B, editors. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. New York, USA: McGraw-Hill Professional; 2002, 2010. p. 1129-61.
7. Bello F, Bakari AG. Hypothyroidism in adults: A review and recent advances in management. J Diabetes Endocrinol 2012;3:57-69.
8. The National Academy of Clinical Biochemistry. Standards of Laboratory Practice. Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease. American Association of Clinical Chemistry; 1996. p. 1-64.
9. Komarica EB, Beciragic A. The importance of HbA1c control in patients with subclinical hypothyroidism. Mater Soc Med 2012;24:212-9.
10. Greenspan FS. The thyroid gland. In: Greenspan FS, Gardner DG, editors. Basic and Clinical Endocrinology. 7th ed. New York: The McGraw-Hill Companies; 2004. p. 215-94.
11. Rizos CV, Elisaf MS, Liberopoulos EN. Effects of thyroid dysfunction on lipid profile. Open Cardiovasc Med J 2011;5:76-84.
12. Proces S, Delgrange E, Vander Borght TV, Jamart J, Donckier JE. Minor alterations in thyroid-function tests associated with diabetes mellitus and obesity in outpatients without known thyroid illness. Acta Clin Belg 2001;56:86-90.
13. Michalek AM, Mahoney MC, Calebaugh D. Hypothyroidism and diabetes mellitus in an American Indian population. J Fam Pract 2000;49:638-40.
14. Helfand M. Screening for subclinical thyroid dysfunction in non-pregnant adults: A summary of the evidence for the U.S. preventive services task force. Ann Intern Med 2004;140:128-41.
15. Shilpashree MK, Ravi BV, Vedavathi. Serum lipoprotein (a) and lipid profile in hypothyroidism. J Clin Biomed Sci 2014;4:235-9.
16. Gwinup G, Morton E. The high lying thyroid: A cause of pseudo goiter. J Clin Endocrinol Metab 1975;40:37-42.
17. Jain G, Marwaha TS, Khurana A, Dhoat PS. Prevalence of thyroid disorders in patients of Type 2 diabetes mellitus. Indian J Med Dent Sci 2013;2:48-52.
18. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease sprevalence study. Arch Intern Med 2000;160:526-34.
19. Jung CH, Sung KC, Shin HS, Rhee EJ, Lee WY, Kim BS, et al. Thyroid dysfunction and their relation to cardiovascular risk factors such as lipid profile, hsCRP, and waist hip ratio in Korea. Korean J Intern Med 2003;18:146-53.
20. Packard CJ, O’Reilly DS, Caslake MJ, McMahon AD, Ford I, Cooney J, et al. Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland coronary prevention study group. N Engl J Med 2000;343:1148-55.
21. Weetman AP, McGregor AM. Autoimmune thyroid disease: Developments in our understanding. Endocr Rev 1984;5:309-55.
22. Mariotti S, Caturegli P, Piccolo P, Barbesino G, Pinchera A. Anti-thyroid peroxidase autoantibodies in thyroid diseases. J Clin Endocrinol Metab 1990;71:661-9.
23. Nordyke RA, Gilbert FI Jr, Miyamoto LA, Fleury KA. The superiority of antimicrosomal over an-tithyroglobulin antibodies for detecting Hashimoto’s thyroiditis. Arch Intern Med 1993;153:862-5.
24. Surks MI, Ocampo E. Subclinical thyroid disease. Am J Med 1996;100:217-23.
Statistics
203 Views | 576 Downloads
Citations
How to Cite
Sharma, A., S. Devi, K. Singh, and P. K. Prabhakar. “CORRELATION OF BODY MASS INDEX WITH THYROID-STIMULATING HORMONES IN THYROID PATIENT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 14, July 2018, pp. 65-68, doi:10.22159/ajpcr.2018.v11s2.28580.
Section
Original Article(s)