HAIR GROWTH ACTIVITY AND SAFETY TEST OF ETHOSOMAL GEL ETHYL ACETATE FRACTION OF NOTHOPANAX LEAVES (NOTHOPANAX SCUTELLARIUM MERR.)


Mahdi Jufri, Lili Amelia, Abdul Munim

Abstract


Objective: The aims of this study were to know the hair growth activity from the ethosomal gel of ethyl acetate fraction compared to the nonethosomal gel of ethyl acetate fraction, as well as its ability to penetrate into the skin and its safety from ethosomal gel testing.

Methods: The hair growth activity was measured by three parameters: Hair length, hair thickness, and hair weight.

Results: The results obtained are shown that the ethosomal gel with concentration 1% has better hair growth activity rather than the ethosomal gel with concentration 0.5% and the nonethosomal gel but it has similarity to the positive control (minoxidil gel with concentration 2%). In vitro penetration test using Franz diffusion cells shown that the ethosomal gel with concentration 1% has cumulative penetration of quercetin higher than nonethosomal gel, which value was 3.3175±0.02 μgcm−2 for the ethosomal gel with concentration 1%; and 2.7663±0.19 μgcm-2 for the nonethosomal gel with flux values for the ethosomal gel with concentration 1% and the nonethosomal gel, respectively, are 0.4147±0.01 μgcm−2h−1 and 0.3458±0.02 μgcm−2h−1.

Conclusion: As for the safety test using hen’s egg test-chorioallantoic membrane (HET- CAM) safety test) have shown that both concentrations 0.5% and 1% of the ethosomal gel can generate mild irritation for topical application.


Keywords


Nothopanax scutellarium, Ethosome, Gel, Hair growth, Franz diffusion cell, Hen’s egg test-chorioallantoic membrane

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About this article

Title

HAIR GROWTH ACTIVITY AND SAFETY TEST OF ETHOSOMAL GEL ETHYL ACETATE FRACTION OF NOTHOPANAX LEAVES (NOTHOPANAX SCUTELLARIUM MERR.)

Keywords

Nothopanax scutellarium, Ethosome, Gel, Hair growth, Franz diffusion cell, Hen’s egg test-chorioallantoic membrane

DOI

10.22159/ajpcr.2017.v10i8.18866

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 8 August 2017 Page: 134-138

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

151 Views | 177 Downloads

Authors & Affiliations

Mahdi Jufri
Department of Pharmaceutical Science, Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, Indonesia
Indonesia

Lili Amelia
Department of Herbal Medicine, Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, Indonesia.
Indonesia

Abdul Munim
Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, Indonesia.
Indonesia


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