BRAIN AND BEHAVIOR – HYPOTHALAMUS AND LIMBIC SYSTEM: THE NEUROBIOLOGY OF EMOTIONS


Anjali Daisy S

Abstract


It is intuitive to understand how sensory information gets to the brain and how motor information can travel to the muscles together where these twosystems allow us to detect and respond to the world around us but how do we engage with that world, how do we determine what is important, andhow do we fall in the analysis. These higher cortical functions involve the complex interplay between neurotransmitters and hormones throughout theentire nervous system. There are two major anatomical behaviors; the limbic system and hypothalamus. These structures that support much highercortical functions hypothalamus is a very small structure but it is absolutely critical for life and it allows us to respond to both the internal and externalenvironment and to maintain homeostasis. The limbic system is important for learning and memory, and all emotional aspects of behavior importantlylimbic and hypothalamic structures are interconnected with each other. Let’s begin with an anatomical overview of the hypothalamus in the middlesection. You can delineate the hypothalamus from the thalamus through the hypothalamic sulcus anteriorly, the hypothalamus extends to the anteriorcommissure, and the optic chiasm inferiorly and it includes the mammillary bodies and extends to the infundibula stock where it communicateswith the pituitary glands. It is a coronal section through the brain. It is the third ventricle, you can identify the thalamus on either side of the thirdventricle and underneath; the thalamus is the hypothalamus and it extends laterally to these descending fiber bundles which are part of the internalcapsule. The hypothalamus is structurally part of the diencephalon but it functions as part of the limbic system through reciprocal connections. Ithelps to maintain homeostasis in the entire body through influences on the endocrine system and importantly through its primary influence onboth the sympathetic and parasympathetic systems; the limbic system is extremely old from an evolutionary perspective in its connections and it isinterposed between the hypothalamus and the neocortex and providing a bridge between endocrine visceral emotional and voluntary responses tothe environment.


Keywords


Hypothalamus, Emotions, Amygdala, Post dramatic stress disorder

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References


Adachi Y, Osada T, Sporns O, Watanabe T, Matsui T, Miyamoto K, et al. Functional connectivity between anatomically unconnected areas is shaped by collective network-level effects in the macaque cortex. Cereb Cortex 2012;22(7):1586-92.

Cavanagh JF, Shackman AJ. Frontal midline theta reflects anxiety and cognitive control: Meta-analytic evidence. J Physiol Paris 2015;109(1-3):3-15.

John YJ, Bullock D, Zikopoulos B, Barbas H. Anatomy and computational modeling of networks underlying cognitive-emotional interaction. Front Hum Neurosci 2013;7:101.

Johnson JS, Kundu B, Casali AG, Postle BR. Task-dependent changes in cortical excitability and effective connectivity: A combined TMS-EEG study. J Neurophysiol 2012;107(9):2383-92.

Kalanthroff E, Cohen N, Henik A. Stop feeling: Inhibition of emotional interference following stop-signal trials. Front Hum Neurosci 2013;7:78.

Lin T, Vaisvaser S, Fruchter E, Admon R, Wald I, Pine D, et al. A neurobehavioral account for individual differences in resilience to chronic military stress. Psychol Med 2014;45(5):1011-23.1-13.

Lindquist KA, Barrett LF. A functional architecture of the human brain: Emerging insights from the science of emotion. Trends Cogn Sci 2012;16(11):533-40.

Birn RM, Shackman AJ, Oler JA, Williams LE, Mcfarlin DR, Rogers GM, et al. Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety. Mol Psychiatry 2014;19(8):915-22.

Moser JS, Moran TP, Schroder HS, Donnellan MB, Yeung N. On the relationship between anxiety and error monitoring: A meta-analysis and conceptual framework. Front Hum Neurosci 2013;7:466.

Admon R, Lubin G, Rosenblatt JD, Stern O, Kahn I, Assaf M, et al. Imbalanced neural responsivity to risk and reward indicates stress vulnerability in humans. Cereb Cortex 2012;23:28-35.

Bar-Haim Y, Lamy D, Pergamin L, Bakermans-Kranenburg MJ, van IJzendoorn MH. Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study. Psychol Bull 2007;133(1):1-24.

Barrett LF, Mesquita B, Ochsner KN, Gross JJ. The experience of emotion. Annu Rev Psychol 2007;58:373.

Berggren N, Derakshan N. Attentional control deficits in trait anxiety: Why you see them and why you don’t. Biol Psychol 2013;92(3):440-6.

Holtmann J, Herbort MC, Wustenberg T, Soch J, Richter S, Walter H, et al. Trait anxiety modulates fronto-limbic processing of emotional interference in borderline personality disorder. Front Hum Neurosci 2013;7:54.

Hare TA, O’Doherty J, Camerer CF, Schultz W, Rangel A. Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors. J Neurosci 2008;28:5623-30.

Murphy KP. Machine Learning: A Probabilistic Perspective. Cambridge, MA: MIT Press; 2012.

Shechner T, Britton JC, Perez-Edgar K, Bar-Haim Y, Ernst M, Fox NA, et al. Attention biases, anxiety, and development: Toward or away from threats or rewards? Depress Anxiety 2012;29(4):282-94.

Campbell DT, Fiske DW. Convergent and discriminant validation by the multitrait-multimethod matrix. Psychol Bull 1959;56(2):81-105.

Caspi A, Roberts BW, Shiner RL. Personality development: Stability and change. Annu Rev Psychol 2005;56:453-84.

Dolcos F, Denkova E. Current emotion research in cognitive neuroscience: Linking enhancing and impairing effects of emotion on cognition. Emot Rev 2014;6:362-75.

Dreisbach G, Fischer R. The role of affect and reward in the conflict-triggered adjustment of cognitive control. Front Hum Neurosci 2012;6:342.

Gross JJ. Antecedent-and response-focused emotion regulation: Divergent consequences for experience, expression, and physiology. J Pers Soc Psychol 1998;74(1):224-37.

Gross JJ. The emerging field of emotion regulation: An integrative review. Rev Gen Psychol 1998;2(3):271.

Hare TA, Camerer CF, Rangel A. Self-control in decision-making involves modulation of the vmPFC valuation system. Science 2009;324(5927):646-8.

Hartley CA, Phelps EA. Anxiety and decision-making. Biol Psychiatry 2012;72(2):113-8.

Heller AS, Lapate RC, Mayer KE, Davidson RJ. The face of negative affect: Trial-by-trial corrugator responses to negative pictures are positively associated with amygdala and negatively associated with ventromedial prefrontal cortex activity. J Cogn Neurosci 2014;26(9):2102-10.

Henderson HA, Pine DS, Fox NA. Behavioral inhibition and developmental risk: A dual-processing perspective. Neuropsychopharmacology 2014;40(1):207-24.

Hakamata Y, Lissek S, Bar-Haim Y, Britton JC, Fox NA, Leibenluft E, et al. Attention bias modification treatment: A meta-analysis toward the establishment of novel treatment for anxiety. Biol Psychiatry 2010;68(11):982-90.

Gilhotra N, Dhingra D. Neurochemical modulation of anxiety disorders. Int J Pharm Pharm Sci 2010;2 Suppl 1:1-6.

Shenhav A, Buckner RL. Neural correlates of dueling affective reactions to win-win choices. Proc Natl Acad Sci U S A 2014;111(30):10978-83.

Sheppes G, Levin Z. Emotion regulation choice: Selecting between cognitive regulation strategies to control emotion. Front Hum Neurosci 2013;7:179.

Siman-Tov T, Papo D, Gadoth N, Schonberg T, Mendelsohn A, Perry D, et al. Mind your left: Spatial bias in subcortical fear processing. J Cogn Neurosci 2009;21(9):1782-9.

Singer N, Eapen M, Grillon C, Ungerleider LG, Hendler T. Through the eyes of anxiety: Dissecting threat bias via emotional-binocular rivalry. Emotion 2012;12(5):960.

Southwick SM, Vythilingam M, Charney DS. The psychobiology of depression and resilience to stress: Implications for prevention and treatment. Annu Rev Clin Psychol 2005;1(1):255-91.

Shenhav A, Botvinick MM, Cohen JD. The expected value of control: An integrative theory of anterior cingulate cortex function. Neuron 2013;79(2):217-40.

Dreisbach G, Fischer R. The role of affect and reward in the conflict-triggered adjustment of cognitive control. Front Hum Neurosci 2012;6:342.

Honey CJ, Sporns O, Cammoun L, Gigandet X, Thiran JP, Meuli R, et al. Predicting human resting-state functional connectivity from structural connectivity. Proc Natl Acad Sci U S A 2009;106(6):2035-40.

Bhagat V, Jayaraj J, Haque M. Parent’s self-efficacy, emotionality, and intellectual ability impacting the intervention of autism spectrum disorders: A review proposed model for appraisal of intervention. Int J Pharm Pharm Sci 2015;7(11):7-12.

Sreenivasan KK, Curtis CE, Desposito M. Revisiting the role of persistent neural activity during working memory. Trends Cogn Sci 2014;18(2):82-9.

Stollstorff M, Munakata Y, Jensen AP, Guild RM, Smolker HR, Devaney JM, et al. Individual differences in emotion-cognitioninteractions: Emotional valence interacts with serotonin transporter genotype to influence brain systems involved in emotional reactivity and cognitive control. Front Hum Neurosci 2013;7:327.

Motzkin JC, Philippi CL, Wolf RC, Baskaya MK, Koenigs M. Ventromedial prefrontal cortex lesions alter neural and physiological correlates of anticipation. J Neurosci 2014;34(31):10430-7.

Pessoa L, Adolphs R. Emotion processing and the amygdala: From a ‘low road’ to “many roads” of evaluating biological significance. Nat Rev Neurosci 2010;11(11):773-83.

Ioannidis JP, Greenland S, Hlatky MA, Khoury MJ, Macleod MR, Moher D, et al. Increasing value and reducing waste in research design, conduct, and analysis. Lancet 2014;383:166-75.

Ioannidis JP, Munafo MR, Fusar-Poli P, Nosek BA, David SP. Publication and other reporting biases in cognitive sciences: Detection, prevalence, and prevention. Trends Cogn Sci 2014;18(5):235-41.

Iordan AD, Dolcos S, Dolcos F. Neural signatures of the response to emotional distraction: A review of evidence from brain imaging investigations. Front Hum Neurosci 2013;7:200.

Lindström BR, Mattsson-Mårn IB, Golkar A, Olsson A. In your face: Risk of punishment enhances cognitive control and error-related activity in the corrugator supercilii muscle. PLoS One 2013;8(6):e65692.

Bishop SJ. Trait anxiety and impoverished prefrontal control of attention. Nat Neurosci 2009;12(1):92-8.

Bishop SJ, Forster S. Trait anxiety, neuroticism and the brain basis of vulnerability to affective disorder. In: Armony J, Vuilleumier P, editors. The Cambridge Handbook of Human Affective Neuroscience. Cambridge: Cambridge University Press; 2013. p. 553-74.

Button KS, Ioannidis JP, Mokrysz C, Nosek BA, Flint J, Robinson ES, et al. Power failure: Why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci 2013;14:365-76.

Damasio A. Human behaviour: Brain trust. Nature 2005;435(7042):571-2.

Davis M, Whalen PJ. The amygdala: Vigilance and emotion. Mol Psychiatry 2001;6(1):13-34.




About this article

Title

BRAIN AND BEHAVIOR – HYPOTHALAMUS AND LIMBIC SYSTEM: THE NEUROBIOLOGY OF EMOTIONS

Keywords

Hypothalamus, Emotions, Amygdala, Post dramatic stress disorder

DOI

10.22159/ajpcr.2017.v10i8.19372

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 8 August 2017 Page: 46-49

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

67 Views | 138 Downloads

Authors & Affiliations

Anjali Daisy S
Department of MBA, School of Management, SASTRA University, Thanjavur, Tamil Nadu, India.
India


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