COST-EFFECTIVENESS ANALYSIS OF CEFTAZIDIME-LEVOFLOXACIN AND CEFOTAXIME-ERYTHROMYCIN AS EMPIRICAL ANTIBIOTIC COMBINATIONS IN RESPIRATORY INFECTION-INDUCED SEPSIS

Dika P Destiani; Tiana Milanda; Susilawati Susilawati; Auliya A Suwantika; Ivan S Pradipta; Eli Halimah; Ajeng Diantini; Sri A Sumiwi; Ahmad Muhtadi; Anas Subarnas; Keri Lestari; Rizky Abdulah

doi:10.22159/ajpcr.2017.v10s2.19515

Authors

Dika P Destiani Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Tiana Milanda Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Susilawati Susilawati Department of Pharmacy, Hasan Sadikin Hospital, Bandung, Indonesia
Auliya A Suwantika Department of Pharmacy, University of Groningen, Groningen, Netherlands
Ivan S Pradipta Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Eli Halimah Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Ajeng Diantini Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Sri A Sumiwi Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Ahmad Muhtadi Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Anas Subarnas Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Keri Lestari Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Rizky Abdulah Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia

DOI:

https://doi.org/10.22159/ajpcr.2017.v10s2.19515

Keywords:

Empirical therapy, Cost-effectiveness, Pharmacoeconomics, Sepsis, Antibiotics

Abstract

Objective:Pharmacoeconomics has become an important consideration in the selection of therapies, including in patients with sepsis caused by respiratory infection. The aim of this study was to determine the most cost-effective antibiotic combination for respiratory infection-induced sepsis at a public hospital in Bandung, Indonesia.

Methods:This retrospective observational study was conducted at one ofpublic hospitals in Bandung. Two interventions were analyzed: (I₁) ceftazidime-levofloxacinÂ and (I₂) cefotaxime-erythromycin; and compared to the major treatment (I₀, the use of other antibiotic combinations). Data were collected from the medical records of inpatients with respiratory infection-induced sepsis from 2010 until 2012. Healthcare perspective was applied by considering only direct medical costs, which were calculated from variable (drug, administrative andtreatment cost) and fixed cost (hospitalization).

Results:Comparing with I₀, net cost per life saved was calculated to be $3,350 (I₁)and $1,589 (1₂). Number of patients survived was considered to be the most significant parameter on affecting the calculation of net cost per life saved.

Conclusion:I₂ was more cost effective than I₁, compared to I₀.

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