CARDIOSPERMUM HALICACABUM LINN. - A REVIEW
Â Before the modern day, medicine and its pharmacopeia of synthetic drugs, there were plants and ancient civilizations knew how to use the plants strategically to treat common ailments and even life-threatening diseases. Natural plant-based remedies are used for the both acute and chronic health problems from treating common colds to control blood pressure and cholesterol. Plant medicines were the most widely used medicines in the world because of their safety and very less or no side effects. In this way, the aim of this review article was to summarize the phytochemical and medicinal information of the readily reachable plant Cardiospermum halicacabum Linn. This is commonly known as Balloon vine extensively dispersed in tropical and subtropical areas of world. The roots, leaves, stem, and seeds of this plant are employed as herbal medication. The phytochemical analysis confirmed that this herb contains flavonoids, terpenoids, tannins, saponin, protein, carbohydrates, glycosides, variety of fatty acids, and volatile esters. Due to the presence of various compounds, this plant has antibacterial, antifungal, antiparasitic, antidiarrheal, anxiolytic, antioxidant, antipyretic, antirheumatic, anticonvulsant, anti-inflammatory, and anticancinogenic activities.
2. Jeyadevi R, Sivasudha T, Ilavarasi A, Thajuddin N. Chemical constituents and antimicrobial activity of Indian green leafy vegetable Cardiospermum halicacabum. Indian J Microbiol 2013;53(1):208-13.
3. Senthilkumar S, Vijayakumari K. Phytochemical and GC-MS analysis of Cardiospermum halicacabum Linn. Leaf. Int J Inst Pharm Life Sci 2013;3 Suppl 5:95-8.
4. Rajasekaran A, Kaliselvan V, Sarathikumar N, Kalaivani M. Simultaneous estimation of luteolin and apigenin in methanolic leaf extract of Cardiospermum halicacabum by HPLC. Int Res J Pharm 2013;4 Suppl 7:109-13.
5. Vinoth B, Manivasagaperumal R. Phytochemical analysis and antibacterial activity of Cardiospermum halicacabum Linn. Int J Curr Sci Technol 2013;2 Suppl 1:9-12.
6. Patil AG, Joshi KA, Patil DA, Chandra N. Pharmacological standardization and HPTLC fingerprint of Cardiospermum halicacabum L. Stem. Res J Pharm Biol Chem Sci 2011;2 Suppl 2:343-52.
7. Annadurai A, Elangovan V, Velmurugan S, Ravikumar R. Preliminary phytochemical screening and antibacterial activity of medicinal plant Cardiospermum halicacabum L. Adv Appl Sci Res 2013;4 Suppl 5:302-8.
8. Rajesh S, Sivakumari K, Ashok K, Abitha AR. Anticancer activity of Cardiospermum halicacabum Linn. Leaf extracts against Hepatocellular carcinoma cell line (Hep-G2). World J Pharm Pharm Sci 2016;5 Suppl 3:1133-54.
9. Aishwarya V, Abdulla SS, Dheeba B, Renuka R. In vitro antioxidant and anticancer activity of Cardiospermum halicacabum L. against EAC cell line. Int J Pharm Pharm Sci 2014;6 Suppl 8:263-8.
10. Viji M, Murugesan S. Phytochemical analysis and antibacterial activity of medicinal plant Cardiospermum halicacabum Linn. J Phytol 2010;2 Suppl 1:68-77.
11. Shareef H, Rizwani GH, Mahmood S, Khursheed R, Zahid H. Invitro Antimicrobial and Phytochemical analysis of Cardiospermum halicacabum L. Pak J Bot 2012;44 Suppl 5:1677-80.
12. Boonmars T, Khunkitti W, Sithithaworn P, Fujimaki Y. In vitro antiparasitic activity of extracts of Cardiospermum halicacabum against third-stage larvae of Strongyloides Stercoralis. Parasitol Res 2005;97 Suppl 5:417-9.
13. Huang MH, Huang SS, Wang BS, Wu CH, Sheu MJ, Hou WC, et al. Anti-oxidant and Anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo. J Ethnopharmacol 2011;133 Suppl 2:743-50.
14. Babu G, Sudhakaran R, Reddy CH. Phytochemical and pharmacological investigations of Cardiospermum halicacabum and Gymnema sylvestre. World J Pharm Pharm Sci 2014;3 Suppl 11:739-58.
15. Babu KC, Kumari SK. Cardiospermum halicacabum suppresses the production of TNF-alpha and nitric oxide by human peripheral blood mononuclear cells. Afr J Biomed Res 2006;9:95-9.
16. Babu KC, Krishnakumari S. Anti-inflammatory and antioxidant compound, rutin in Cardiospermum halicacabum leaves. Anc Sci Life 2005;25(2):47-9.
17. Shobanadevi S, Nandhini P, Tripathi H, Hari R. Antioxidant activity of combined ethanolic extract of Pisonia grandis and Cardiospermum halicacabum. Int J Pharm Sci Res 2016;39 Suppl 1:95-100.
18. Kumaran A, Karunakaran RJ. Antioxidant activities of the methanol extract of Cardiospermum halicacabum. J Pharm Biol 2006;44(2):146-51.
19. Molina V. DPPH radical scavenging activity and reducing power of balloon vine (Cardiospermum halicacabum Linn.) leaf extract. Int J Trend Res Dev 2016;3 Suppl 3:531-3.
20. Annamalai A, Ponmari G, Sathishkumar R, Lakshmi PT. Effect of drying treatment on the contents of antioxidants in Cardiospermum halicacabum Linn. Int J Pharm Biosci 2011;2 Suppl 1:304-13.
21. Asha VV, Pushpangadan P. Antipyretic activity of Cardiospermum halicacabum. Indian J Exp Biol 1999;37:411-4.
22. Abdullahi AL, Agho MO, Amos S, Gamaniel KS, Wambebe C. Antidiarrhoeal activity of the aqueous extract of Terminalia avicennoides roots. Phytother Res 2001;15(5):431-4.
23. Prakash KC, Kuppast IJ. Antidiarrhoeal activity of Cardiospermum halicacabum and Dodonea Viscosa. Int J Pharm Sci 2014;6 Suppl 10:257-60.
24. Rao NV, Prakash KC, Kumar SM. Pharmacological investigation of Cardiospermum halicacabum (Linn.) in different animal models of diarrhoea. Indian J Pharmacol 2006;38 Suppl 5:346-9.
25. Narayani PC, Anbu J, Vasuk R, Hari R. In vitro and in vivo anti-arthritic activity of combined ethanolic extracts of Calotropis gigantean and Cardiospermum halicacabum in Wistar Rats. J Nat Remedies 2014;14 Suppl 1:58-66.
26. Jeyadevi R, Sivasudha T, Rameshkumar A, Dineshkumar L. Anti-arthritic activity of the Indian leafy vegetable Cardiospermum halicacabum in Wistar rats and UPLC-QTOF-MS/MS identification of the putative active phenolic components. Inflamm Res 2013;62 Suppl 1:115-26.
27. Aiyalu R, Subramaniam I, Govindarajan A, Ramasamy A. Evaluation of synergistic effect of methanol leaf extract of Cardiospermum halicacabum and Vitex negundo on inflammation and arthritis. J Herbs Spices Med Plants 2014;20 Suppl 4:372-85.
28. Aiyalu R, Govindarajan A, Ramasamy A. Formulation and evaluation of tropical herbal gel for the treatment of arthritis in animal model. Braz J Pharm Sci 2016;52 Suppl 3:493-507.
29. Kumar KE, Mastan SK, Reddy GA, Raghunandhan N, Sreekanth N, Chaitanya, G. Anti-arthritic property of the ethanolic leaf extract of Cardiospermum halicacabum Linn. Biomed Pharmacol J 2008;1 Suppl 2:467.
30. Padmini N, Sundaramoorthy SD, Tripathi H, Hari. In vitro and in vivo anti-arthritic activity of combined ethanolic extract of Pisonia grandis and Cardiospermum halicacabum in Wistar rats. J Appl Pharm Sci 2016;6 Suppl 9:102-8.
31. Selvi RS, Bai GV. A comparative study of anti-arthritic efficacy of Cardiospermum halicacabum (L) and Cissus vitiginia (L) freundâ€™s complete adjuvant induced arthritis. Int J Res Biol Sci 2014;4 Suppl 4:94-100.
32. Mahmood R, Najam R, Rizwani GH, Khatoon H. Evalution of neuropharmacological activity of Cardiospermum halicacabum (Linn.) leaf extract. World J Pharm Pharm Sci 2016;5 Suppl 3:896-906.
33. Malaviya SN, Andhakumar K, Vghasiya J, Bhalodiya Y, Jivani N, Sheth N, et al. Anxiolytic activity of root extracts of Cardiospermum halicacabum in mice. Internet J Pharmacol 2009;7 Suppl 1:1.
34. Rajeshkumar G, Murugananthan G, Nandakumar K, Talwar S. Isolation of anxiolytic principle from ethanolic root extract of Cardiospermum halicacabum. Phytomedicine 2011;18 2 Suppl 3:219-23.
35. Sudha K, Mathangi SK. Functional compounds of some traditional greens and its medicinal properties. Int J Univ Pharm Biosci 2013;2 Suppl 4:267-92.
36. Stalin C, Vivekanandhan K, Bhavya E. In vitro antidiabetic activity of Cardiospermum halicacabum Leaves extract. Glob J Med Res B 2013;13 Suppl 7:41-3.
37. Gandhi GR, Sasikumar P. Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats. Asian Pac J Trop Biomed 2012;2:281-6.
38. Veeramani C, Pushpavalli G, Pugalendi KV. Antihyperglycaemic effect of Cardiospermum halicacabum Linn. Leaf extract on STZ-induced diabetic rats. J Appl Biomed 2008;6:19-26.
39. Rajeswari R, Sridevi M. Study on in vitro glucose uptake activity of isolated compounds from hydroalcoholic leaf extract of Cardiospermum halicacabum Linn. Int J Pharm Pharm Sci 2014;6 Suppl 11:181-5.
40. Govindappa M. A review on role of plant(s)extract and its phytochemicals for the treatment of diabetes. J Diabetes Metab 2015;6 Suppl 7:565.
41. Naik VK, Babu KS, Latha J, Prabakar V. A review on its ethnobotany, phytochemical and pharmacological profile of Cardiospermum halicacabum Linn. Int J Pharm Res Biosci 2014;3 Suppl 6:392-402.
42. Vetrichlvan T, Narasimhana CL, Venkatramani R. Antionvulsant action of petroleum ether fraction of Cardiospermum halicacabum against electroshock induced convulsion in rats. Ancient Sci Life 2000;19 3 Suppl 4:1-3.
43. Kukkar MR, Saluja AK, Sachdeva PD, Kukkar RR. In vivo investigation of the neuroprotective potential of Cardispermum halicacabum Linn. Int J Pharm Pharm Sci 2014;6 Suppl 4:64-6.
44. Sagadevan P, Suresh SN, Rathishkumar S, Gayathri S, Eswari DV. Anticancer activity of methanolic leaf extract of Andrographis paniculata (Nees) and Cardiospermum halicacabum (Linn.) against human breast cell cancer cell line. (MCF-7). Int J Pharm Life Sci 2013;4 Suppl 9:2983-6.
45. Jacob B, Natarajan S, Pattiyappan S, Sivaraman R, Suresh MS. Study on anti-carcinogenic and apoptotic properties of methanolic stem extract of Cardiospermum halicacabum in MCF7 cell line. J Sci Innov Res 2015;4 Suppl 1:43-8.
46. Arunkumar S, Valentina P, Deepa G, Anitapriyadharshini K, Rekha D, Sreekiran M, et al. Preliminary phytochemical analysis, HPTLC finger printing and in vitro anticancer screening of extracts of aerial parts of Cardiospermum halicacabum. Int J Pharm Pharm Sci 2013;5 Suppl 3:301-4.
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