• Rano K Sinuraya Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, UniversitasPadjadjaran, Indonesia
  • Sharon Gondodiputro Department of Public Health, Faculty of Medicine, UniversitasPadjadjaran, Indonesia
  • Henni Djuhaeni Department of Public Health, Faculty of Medicine, UniversitasPadjadjaran, Indonesia


Objective:Stress ulcer prophylaxis is generallyadministered for the prevention stress-related mucosal disease (SRMD) in critically ill patients. Proton Pump Inhibitors (PPIs) are most commonly prescribed in preventing bleeding from SRMD. Pantoprazole iv and omeprazole iv are the most effective, but clinically effective is not always efficient. Thisstudy aimed to investigate whether the most efficient PPIs for prophylaxis in ICU settings.

Methods:An observational study was conducted on June 2014 with comparative design by using medical records in January 2012−November 2014 in a private hospital in Bandung City. Both retrospective and prospective data collection was performed in this study. Paired t-test analysis was used to compare average cost of the drugs with significant level p<0.05.

Results:The results showed average cost of pantoprazole iv 458.142 IDR/patient and omeprazole iv 575.573 IDR/patient, there were significant differences of average drug cost between pantoprazole iv and omeprazole iv (p=0.0085).

Conclusion:Both pantoprazole iv and omeprazole iv were effective but pantoprazole ivhad been found more efficient.

Keywords: Cost analysis, PPIs, Prophylaxis, Stress ulcer bleeding.


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How to Cite
Sinuraya, R. K., S. Gondodiputro, and H. Djuhaeni. “PROTON PUMP INHIBITORS FOR STRESS ULCER BLEEDING PROPHYLAXIS IN CRITICALLY ILL PATIENTS: A COST ANALYSIS STUDY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 14, May 2017, pp. 128-30, doi:10.22159/ajpcr.2017.v10s2.20413.
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