• Bhongir Aparna Varma Department of Biochemistry, Mediciti Institute of Medical Sciences, Medchal, Telangana, India.
  • Srilatha Bashetti Department of Biochemistry, Apollo Institute of Medical sciences & Research, Hyderabad, Telangana, India.
  • Rajagopalan Vijayaraghavan Department of Research, Saveetha University, Chennai, Tamil Nadu, India.
  • Kumar Sai Sailesh Department of Physiology, DM Wayanad Institute of Medical Sciences, Wayanad, Kerala, India.


 Epigenetics is one of the exciting and fastest expanding fields of biology; this is above genetics. Methylation is the process involved in the transfer of methyl group to amino acids, proteins, enzymes and DNA of all the cells, and tissues of the body. During cell-division low folate availability may result in decreased production of thymidine wherein uracil may be substituted in the place of thymidine in the DNA sequence. It was reported that folate and Vitamin B12 restricted diet resulted in aberrant methylation patterns. The current review was undertaken to explore the role of folic acid and Vitamin B12 in DNA methylation.

Keywords: DNA methylation, Folic acid, Vitamin B12.

Author Biographies

Bhongir Aparna Varma, Department of Biochemistry, Mediciti Institute of Medical Sciences, Medchal, Telangana, India.
Kumar Sai Sailesh, Department of Physiology, DM Wayanad Institute of Medical Sciences, Wayanad, Kerala, India.
pl consider


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How to Cite
Varma, B. A., S. Bashetti, R. Vijayaraghavan, and K. S. Sailesh. “FOLIC ACID, VITAMIN B12, AND DNA METHYLATION: AN UPDATE.”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 1, Jan. 2018, pp. 17-20, doi:10.22159/ajpcr.2018.v11i1.21892.
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