FOLIC ACID, VITAMIN B12, AND DNA METHYLATION: AN UPDATE.


Bhongir Aparna Varma, Srilatha Bashetti, Rajagopalan Vijayaraghavan, Kumar Sai Sailesh

Abstract


 Epigenetics is one of the exciting and fastest expanding fields of biology; this is above genetics. Methylation is the process involved in the transfer of methyl group to amino acids, proteins, enzymes and DNA of all the cells, and tissues of the body. During cell-division low folate availability may result in decreased production of thymidine wherein uracil may be substituted in the place of thymidine in the DNA sequence. It was reported that folate and Vitamin B12 restricted diet resulted in aberrant methylation patterns. The current review was undertaken to explore the role of folic acid and Vitamin B12 in DNA methylation.


Keywords


DNA methylation, Folic acid, Vitamin B12.

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About this article

Title

FOLIC ACID, VITAMIN B12, AND DNA METHYLATION: AN UPDATE.

Keywords

DNA methylation, Folic acid, Vitamin B12.

DOI

10.22159/ajpcr.2018.v11i1.21892

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 1 January 2018 Page: 17-20

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Bhongir Aparna Varma
Department of Biochemistry, Mediciti Institute of Medical Sciences, Medchal, Telangana, India.
India

Srilatha Bashetti
Department of Biochemistry, Apollo Institute of Medical sciences & Research, Hyderabad, Telangana, India.
India

Rajagopalan Vijayaraghavan
Department of Research, Saveetha University, Chennai, Tamil Nadu, India.
India

Kumar Sai Sailesh
Department of Physiology, DM Wayanad Institute of Medical Sciences, Wayanad, Kerala, India.
India


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