THE RELATIONSHIP BETWEEN BLOOD PRESSURE AND PUPIL TO LIMBUS DIAMETER RATIO IN HYPERTENSIVE WOMEN: A PILOT STUDY

  • Archana Rajagopalan Department of Physiology, Saveetha Medical College, Saveetha University, Chennai, Tamil Nadu, India
  • Kumar Sai Sailesh Department of Physiology, DM Wayanad Institute of Medical Sciences, Naseera Nagar, Meppadi (P.O), Wayanad, Kerala, India.
  • Srilatha Bashetti Department of Biochemistry, Apollo Institute of Medical Sciences and Research, Hyderabad, Telangana, India
  • Soumya Mishra Department of Physiology, JIPMER, Pondicherry, India.

Abstract

 

 Objective: This study was undertaken to observe the relationship between blood pressure (BP) and pupil to limbus diameter (PLD) ratio in hypertensive working women.

Methods: A total of 30 hypertensive working women were part of the study after obtaining written, voluntary, informed consent, and ensuring confidentiality. PLD ratio was measured by two-box method as described in the literature.

Results: Positive correlation was observed between PLD ratio of the right eye (r=0.951) and left eye (r=0.927) and systolic BP. This correlation is statistically significant at 0.01 levels (two tailed). Positive correlation was observed between PLD ratio of the right eye (r=0.844) and left eye (r=0.828) and diastolic BP. This correlation is statistically significant at 0.01 levels (two tailed). Positive correlation was observed between PLD ratio of the right eye (r=0.416) and left eye (r=0.396) and pulse pressure. This correlation is statistically significant at 0.05 levels (two tailed). Positive correlation was observed between PLD ratio of the right eye (r=0.883) and left eye (r=0.844) and mean arterial BP. This correlation is statistically significant at 0.05 levels (two tailed). Positive correlation was observed between PLD ratio of the right eye (r=0.841) and left eye (r=0.819) and pulse rate. This correlation is statistically significant at 0.05 levels (two tailed).

Conclusion: Positive correlation was observed between PLD ratio and autonomic parameters. We recommend further detailed studies to utilize the measurement of PLD ratio as an autonomic function test.

Keywords: Pupil, Limbus, Autonomic parameters, Blood pressure, Hypertension.

Author Biography

Archana Rajagopalan, Department of Physiology, Saveetha Medical College, Saveetha University, Chennai, Tamil Nadu, India
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References

1. FrancoEmanuele Di AngelantonioDorairaj PrabhakaranJ HypertensChobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003;42(6):1206-52.
2. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: The JNC 7 report. JAMA 2003;289(19):2560-72.
3. Wassertheil-Smoller S, Anderson G, Psaty BM, Black HR, Manson J, Wong N, et al. Hypertension and its treatment in postmenopausal women: Baseline data from the Women’s Health Initiative. Hypertension 2000;36(5):780-9.
4. Gudmundsdottir H, Høieggen A, Stenehjem A, Waldum B, Os I. Hypertension in women: Latest findings and clinical implications. Ther Adv Chronic Dis 2012;3(3):137-46.
5. Gulec S. Early diagnosis saves lives: Focus on patients with hypertension. Kidney Int Suppl 2013;3(4):332-4.
6. Yamanaka K, Kawakami M. Convenient evaluation of mental stress with pupil diameter. Int J Occup Saf Ergon 2009;15(4):447-50.
7. Mojumder DK, Patel S, Nugent K, Detoledo J, Kim J, Dar N, et al. Pupil to limbus ratio: Introducing a simple objective measure using two box method for measuring early aniscoria and progress of pupillary change in the ICU. J Neurosci Rural Pract 2015;6(2):208-15.
8. Sajeevan A, Sailesh KS. Correlation of pupil to limbus diameter ratio with blood pressure and pulse rate. Int J Pharm Bio Sci 2017;8(3):B12-6.
9. Kumar SS, Rajagopalan A, Mukkadan JK. Vestibular stimulation for stress management in students. J Clin Diagn Res 2016;10(2):CC27-31.
10. World Health Organization. Global Brief on Hypertension. Geneva: World Health Organization; 2013.
11. Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380(9859):2224-60.
12. O’Brien E, Pickering T, Asmar R, Myers M, Parati G, Staessen J, et al. Working group on blood pressure monitoring of the European society of hypertension international protocol for validation of blood pressure measuring devices in adults. Blood Press Monit 2002;7(1):3-17.
13. Qureshi AI, Suri MF, Kirmani JF, Divani AA, Mohammad Y. Is prehypertension a risk factor for cardiovascular diseases? Stroke 2005;36(9):1859-63.
14. Wu S, Huang Z, Yang X, Li S, Zhao H, Ruan C, et al. Cardiovascular events in a prehypertensive Chinese population: Four-year follow-up study. Int J Cardiol 2013;167(5):2196-9.
15. Huang Y, Wang S, Cai X, Mai W, Hu Y, Tang H, et al. Prehypertension and incidence of cardiovascular disease: A meta-analysis. BMC Med 2013;11:177.
16. Kim MJ, Lim NK, Park HY. Relationship between prehypertension and chronic kidney disease in middle-aged people in Korea: The Korean genome and epidemiology study. BMC Public Health 2012;12:960.
17. Anchala R, Kannuri NK, Pant H, Khan H, Franco OH, Di Angelantonio E, et al. Hypertension in India: A systematic review and meta-analysis of prevalence, awareness, and control of hypertension. J Hypertens 2014;32(6):1170-7.
18. Venkataraman R, Kumar BP, Kumaraswamy M, Singh R, Pandey M, Tripathi P, et al. Smoking, alcohol and hypertension. Int J Pharm Pharm Sci 2013;5(4):28-32.
19. Dhianawaty DD, Heryaman H, Syamsunarno MR. Blood pressure profiles among east bongas and west bongas people in effort and support from universitas Padjadjaran and the regent of Majalengka regency and chieves of the villages. Int J Pharm Pharm Sci 2017;9(6):215-9.
20. Oyster CW, editor. The Iris and the pupil. The Human Eye: Structure and Function. Sunderland, Mass: Sinauer Associates; 1999. p. 411-46.
21. Beatty J, Lucero-Wagoner B. The pupillary system. In: Cacioppo JT, Tassinary LG, Berntson GG, editors. Handbook of Psychophysiology. Cambridge, UK: Cambridge University Press; 2000. p. 14-62.
22. Walker HK, Hall WD, Hurst JW. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Ch. 58. Boston, MA: Butterworths; 1990.
23. Bradley MM, Miccoli L, Escrig MA, Lang PJ. The pupil as a measure of emotional arousal and autonomic activation. Psychophysiology 2008;45(4):602-7.
24. Fotiou F, Fountoulakis KN, Goulas A, Alexopoulos L, Palikaras A. Automated standardized pupillometry with optical method for purposes of clinical practice and research. Clin Physiol 2000;20(5):336-47.
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How to Cite
Rajagopalan, A., K. S. Sailesh, S. Bashetti, and S. Mishra. “THE RELATIONSHIP BETWEEN BLOOD PRESSURE AND PUPIL TO LIMBUS DIAMETER RATIO IN HYPERTENSIVE WOMEN: A PILOT STUDY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 11, Nov. 2017, pp. 142-4, doi:10.22159/ajpcr.2017.v10i11.20528.
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