EFFECT OF VESTIBULAR STIMULATION ON BEHAVIORAL CHANGES IN PARKINSON DISEASE-INDUCED MICE

Authors

  • Ram mohan Department of Physiotherapy, KMCH college of Physiotherapy, Coimbatore, Tamil Nadu, India. https://orcid.org/0000-0003-1140-9103
  • Mohan jayabal Department of Physiology, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India. https://orcid.org/0000-0001-9869-9910
  • Rashmi Ramanathan Department of Physiology, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India. https://orcid.org/0000-0001-8710-9639
  • Jeevithan shanmugam Department of Community Medicine, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India. https://orcid.org/0000-0002-6289-587X
  • Archana R Department of Physiology, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i9.45004

Keywords:

Vestibular stimulation, Parkinson’s disease, Behavioural changes, Elevated plus maze, open field test

Abstract

Objective: This prospective study was conducted to provide an authoritative database for beneficial effects of vestibular stimulation, a simple non-invasive method to alleviate the behavioral changes in Parkinson’s disease (PD).

Methods: Vestibule is stimulated by caloric vestibular stimulation (CVS). Pesticide Rotenone is used to induce PD. Open field test and elevated plus maze were used to access learning, memory, and behavior.

Results: Behavioral scores were taken before and after stimulation of the vestibular system. The scores were significantly different between rotenone-induced PD, control, and hot water vestibular stimulation groups (p<0.05).

Conclusion: This study categorically confirms that CVS with hot water causes behavioral changes in PD. This study certainly merits further studies with higher sample sizes to confirm the effect of CVS for enhancement of learning, memory, and behavior in patients with Parkinsonism.

Downloads

Download data is not yet available.

References

Tanner CM, Goldman SM. Epidemiology of Parkinson’s disease. Neurol Clin 1996;14:317-35. doi: 10.1016/S0733-8619(05)70259-0, PMID 8827174.

Fearnley JM, Lees AJ. Ageing and Parkinson’s disease: Substantia nigra regional selectivity. Brain 1991;114:2283-301. doi: 10.1093/ brain/114.5.2283, PMID 1933245.

Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, et al. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson’s disease and dementia with Lewy bodies. Am J Pathol 1998;152:879-84. PMID 9546347.

Pechtel P, Pizzagalli DA. Effective early life stress on cognitive and affective function: An integrated review of human literature. Psychopharmacology 2011;214:55-70.

IracemaLeroi N. Cognitive and Behavioural Complications of Parkinson’s Disease. United States: American Consolidated Natural Resources; 2010. p. 10-4.

Jamdhade VC, Surwase BS. Memory enhancing activity of Taverniera cuneifolia (roth) arn: A substitute for commercial liquorice. Int J Pharm Biol Sci 2013;4:277-85.

Dastmalchi K, Dorman HJ, Vuorela H, Hiltunen R. Plants as potential sources for drug development against Alzheimer’s disease. Int J Biomed Pharm Sci 2007;1:83-104.

Archana R, Sailesh KS, Riya AK, Udaya KR, Mukkadan JK. Vestibular stimulation: A physiological intervention for depression-a hypothesis. Res J Pharm Biol Chem Sci 2015;6:950-2.

Sailesh KS, Mukkadan JK. Vestibular modulation of endocrine secretions-a review. Int J Res Health Sci 2014;2:68-78.

Gopinath A, Archana R, Sailesh KS, Mukkadan JK. Effect of caloric vestibular stimulation on memory. Int J Pharm Biol Sci 2015;6:453-9.

Samoudi G, Jivegård M, Mulavara AP, Bergquist F. Effects of stochastic vestibular galvanic stimulation and Ldopa on balance and motor symptoms in patients with Parkinson’s disease. Brain Stimul 2015;8:474-80. doi: 10.1016/j.brs.2014.11.019, PMID 25573070.

Kataoka H, Okada Y, Kiriyama T, Kita Y, Nakamura J, Morioka S, et al. Can postural instability respond to galvanic vestibular stimulation in patients with Parkinson’s disease? J Mov Disord 2016;9:40-3. doi: 10.14802/jmd.15030, PMID 26648182.

Bronikowski AM, Carter PA, Swallow JG, Girard IA, Rhodes JS, Garland T. Open-field behavior of house mice selectively bred for high voluntary wheel-running. Behav Genet 2001;31:309-16. doi: 10.1023/a:1012283426530, PMID 11699603.

Stemmelin J, Cohen C, Terranova JP, Grancha LM, Pichat P, Bergis O, et al. Stimulation of the beta3-adrenoceptor as a novel treatment strategy for anxiety and depressive disorders. Neuropsychpharm 2008;33:574-87.

Giddings JM. Modelling the Behaviour of Rats in an Elevated Plus- Maze. Canada: Acadia University; 2002.

Walsh RN, Cummins RA. The open-field test. A critical review. Psychol Bull 1976;83:482-504. doi: 10.1037/0033-2909.83.3.482, PMID 17582919.

Balaban CD, Beryozkin G. Vestibular nucleus projections to nucleus tractus solitarius and the dorsal motor nucleus of the vagus nerve: Potential substrates for vestibulo-autonomic interactions. Exp Brain Res 1994;98:200-12. doi: 10.1007/BF00228409, PMID 8050507.

Yates BJ, Grélot L, Kerman IA, Balaban CD, Jakus J, Miller AD. The organization of vestibular inputs to nucleus tractus solitarius (NTS) and adjacent structures in the cat brainstem. Am J Physiol 1994;267:R974-83. doi: 10.1152/ajpregu.1994.267.4.R974, PMID 7524372.

Balaban CD. Neural substrates linking balance control and anxiety. Physiol Behav 2002;77:469-75. doi: 10.1016/s0031-9384(02)00935-6, PMID 12526985.

Lundblad M, Andersson M, Winkler C, Kirik D, Wierup N, Cenci MA. Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson’s disease. Eur J Neurosci 2002;15:120-32. doi: 10.1046/j.0953-816x.2001.01843.x, PMID 11860512.

Tai SK, Leung LS. Vestibular stimulation enhances hippocampal long-term potentiation via activation of cholinergic septohippocampal cells. Behav Brain Res 2012;232:174-82. doi: 10.1016/j.bbr.2012.04.013, PMID 22521836.

Kawai H, Lazar R, Metherate R. Nicotinic control of axon excitability regulates thalamocortical transmission. Nat Neurosci 2007;10:1168-75. doi: 10.1038/nn1956, PMID 17704774. doi: 10.1038/nn1956, PMID 17704774.

Dilda V, MacDougall HG, Curthoys IS, Moore ST. Effects of Galvanic vestibular stimulation on cognitive function. Exp Brain Res 2012;216:275-85. doi: 10.1007/s00221-011-2929-z, PMID 22076407.

Published

07-09-2022

How to Cite

mohan, R., M. . jayabal, R. . Ramanathan, J. shanmugam, and A. . R. “EFFECT OF VESTIBULAR STIMULATION ON BEHAVIORAL CHANGES IN PARKINSON DISEASE-INDUCED MICE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 9, Sept. 2022, pp. 84-87, doi:10.22159/ajpcr.2022.v15i9.45004.

Issue

Section

Original Article(s)