NEEM (AZADIRACHTA INDICA A. JUSS) AS A SOURCE FOR GREEN SYNTHESIS OF NANOPARTICLES

Authors

  • Girish K Department of Microbiology, Maharani’s Science College for Women, Mysuru – 570 008, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i3.21939

Keywords:

Azadirachta indica, Neem, Nanoparticles, Antimicrobial activity

Abstract

 Nanoscience has found various applications in different biomedical fields. The synthesis of nanoparticles (NPs) has become a vast area of research due to its potential applications. These particles can be prepared by different chemical, physical, and biological approaches. In recent years, green synthesis of NPs using plant extracts has gained much interest due to non-toxicity and very low cost of synthesis. The plant extracts act both as reducing agent as well as capping agent. Neem (Azadirachta indica A. Juss) is a well-known medicinal plant and has been studied for the biosynthesis of NPs. A. indica has various phytochemicals identified that can reduce the metal ions. The bioreduction of NPs from neem extract is an eco-friendly, low cost, and green synthesis method and these NPs are reported to exhibit good antimicrobial, mainly antibacterial, activity

Downloads

Download data is not yet available.

Author Biography

Girish K, Department of Microbiology, Maharani’s Science College for Women, Mysuru – 570 008, Karnataka, India.

Assistant Professor

Postgraduate Department of Microbiology

References

Vivehananthan K, Sudha Lakshmi SY, De Silva WH, Kumar SA. Silver nanoparticles of Azadirachta indica: Biological method of synthesis and characterization. World J Pharm Res 2015;4:77-86.

Taniguchi N. On the Basic Concept of Nano-Technology. In: Proceedings of International Conference on Product Engineering Part II. Tokyo: Japan Society of Precision Engineering; 1974. p. 18-23.

Taylor BN, editors. The International Systems of Units (SI). Washington, DC: United States Department of Commerce, National Institute of Standards and Technology, NIST Special Publication; 2001. p. 330.

Prathna TC, Mathew L, Chandrasekaran N, Raichur AM, Mukherjee A. Biomimetic synthesis of nanoparticles: Science, technology and applicability. In: Mukherjee A, editor. Biomimetics Learning from Nature. 2010. Available from: http://www.InTechOpen.com/books.

Namratha N, Monica PV. Synthesis of silver nanoparticles using Azadirachta indica (Neem) extract and usage in water purification. Asian J Pharm Tech 2013;3:170-4.

Ingale AG, Chaudhari AN. Biogenic synthesis of nanoparticles and potential applications: An eco-friendly approach. J Nanomed Nanotechol 2013;4:165.

Ahmad A, Mukherjee P, Senapati S, Mandal D, Khan MI, Kumar R. Extracellular biosynthesis of silver nanoparticles using the fungus Fusarium oxysporum. Colloids Surf B 2003;28:313-8.

Jacob J, Kapoor S, Biswas N, Mukherjee T. Size tunable synthesis of silver nanoparticles in water-ethylene glycol mixtures. Colloids Surf A 2007;301:329-34.

Sharma VK, Yngard RA, Lin Y. Silver nanoparticles: Green synthesis and their antimicrobial activities. Adv Colloid Interface Sci 2009;145:83-96.

Qiaoxin Z, Hao L, Xiaohui W, Xiaoliang S, Xinglong D. Fabrication and characterization of nanosilver powder prepared by spray pyrolysis. J Wuhan Univ Technol Mater Sci 2009;24:871-4.

Tavakoli A, Sohrabi M, Kargari A. A review of methods for synthesis of nanostructured metals with emphasis on iron compounds. Chem Pap 2007;61:151-70.

Ahmed S, Ahmad M, Swami BL, Ikram S. Plants extract mediated synthesis of silver nanoparticles for antimicrobial applications: A green expertise. J Adv Res 2016;7:17-28.

Antony E, Gunasekaran S, Sathiavelu M, Arunachalam S. A review on use of plant extracts for gold and silver nanoparticle synthesis and their potential activities against food pathogens. Asian J Pharm Clin Res 2016;9:18-23.

Sun Y, Xia Y. Shape-controlled synthesis of gold and silver nanoparticles. Science 2002;298:2176-9.

Resmi CR, Sreejamol P, Pillai P. Green synthesis of silver nanoparticles using Azadirachta indica leaves extract and evaluation of antibacterial activities. Int J Adv Biol Res 2014;4:300-3.

Thirumurugan A, Aswitha P, Kiruthika C, Nagarajan S, Christy AN. Green synthesis of platinum nanoparticles using Azadirachta indica-an eco-friendly approach. Mater Lett 2016;170:175-8.

Konishi Y, Ohno K, Saitoh N, Nomura T, Nagamine S. Microbial synthesis of gold nanoparticles by metal reducing bacterium. Trans Mater Res Soc Jpn 2004;29:2341-3.

Ahmad A, Senapati S, Khan MI, Kumar R, Sastry M. Extracellular biosynthesis of monodisperse gold nanoparticles by a novel extremophilic actinomycete, Thermomonospora sp. Langmuir 2003;19:3550-3.

Balagurunathan R, Radhakrishnan M, Rajendran RB, Velmurugan D. Biosynthesis of gold nanoparticles by actinomycete Streptomyces viridogens strain HM10. Indian J Biochem Biophys 2011;48:331-5.

Lengke M, Fleet M, Southam G. Biosynthesis of silver nanoparticles by filamentous cyanobacteria from a silver(I) nitrate complex. Langmuir 2006;10:1021-30.

Bhainsa KC, D’Souza SF. Extracellular biosynthesis of silver nanoparticles using the fungus Aspergillus fumigatus. Colloids Surf B Biointerfaces 2006;47:160-4.

Mukherjee P, Roy M, Mandal BP, Dey GK, Mukherjee PK, Ghatak J, et al. Green synthesis of highly stabilized nanocrystalline silver particles by a non-pathogenic and agriculturally important fungus T. Asperellum. Nanotechnology 2008;19:075-103.

Ravindra BK, Rajasab AH. Silver nanoparticles synthesis from different fungal species and their antifungal effect. Int J Pharm Pharm Sci 2015;7:165-70.

Marshall MJ, Beliaev AS, Dohnalkova AC, Kennedy DW, Shi L, Wang Z, et al. C-type cytochrome-dependent formation of U(IV) nanoparticles by Shewanella oneidensis. PLoS Biol 2006;4:e268.

Prasad K, Jha AK, Kulkarni AR. Lactobacillus assisted synthesis of titanium nanoparticles. Nanoscale Res Lett 2007;2:248-50.

Kirthi AV, Rahuman AA, Rajakumar G, Marimuthu S, Santhoshkumar T, Jayaseelan C, et al. Biosynthesis of titanium dioxide nanoparticles using bacterium Bacillus subtilis. Mater Lett 2011;65:2745-7.

Chandran SP, Chaudhary M, Pasricha R, Ahmad A, Sastry M. Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract. Biotechnol Prog 2006;22:577-83.

Bar H, Bhui DK, Sahoo GP, Sarkar P, De SP, Misra A. Green synthesis of silver nanoparticles using latex of Jatropha curcas. Colloids Surf A 2009;339:134-9.

Krishnaraj C, Jagan EG, Rajasekar S, Selvakumar P, Kalaichelvan PT, Mohan N, et al. Synthesis of silver nanoparticles using Acalypha indica leaf extracts and its antibacterial activity against water borne pathogens. Colloids Surf B Biointerfaces 2010;76:50-6.

Nabikhan A, Kandasamy K, Raj A, Alikunhi NM. Synthesis of antimicrobial silver nanoparticles by callus and leaf extracts from saltmarsh plant, Sesuvium portulacastrum L. Colloids Surf B Biointerfaces 2010;79:488-93.

Veerasamy R, Xin TZ, Gunasagaran S, Xiang TF, Yang EF, Jeyakumar N, et al. Biosynthesis of silver nanoparticles using Mangosteen leaf extract and evaluation of their antimicrobial activities. J Saudi Chem Soc 2011;15:113-20.

Logeswari P, Silambarasan S, Abraham J. Synthesis of silver nanoparticles using plants extract and analysis of their antimicrobial property. J Saudi Chem Soc 2012;19:311-7.

Banerjee P, Satapathy M, Mukhopahayay A, Das P. Leaf extract mediated green synthesis of silver nanoparticles from widely available Indian plants: Synthesis, characterization, antimicrobial property and toxicity analysis. Bioresour Bioprocess 2014;1:3.

Kumar SA, Ravi S, Velmurugan S. Green synthesis of silver nanoparticles from Gloriosa superba L. leaf extract and their catalytic activity. Spectrochim Acta A Mol Biomol Spectrosc 2013;115:388-92.

Logeswari P, Silambarasan S, Abraham J. Ecofriendly synthesis of silver nanoparticles from commercially available plant powders and their antibacterial properties. Sci Iran 2013;20:1049-54.

Ghaffari-Moghaddam M, Hadi-Dabanlou R. Plant mediated green synthesis and antibacterial activity of silver nanoparticles using Crataegus douglasii fruit extract. J Indus Eng Chem 2014;20:739-44.

Bindhu MR, Umadevi M. Antibacterial and catalytic activities of green synthesized silver nanoparticles. Spectrochim Acta A Mol Biomol Spectrosc 2015;135:373-8.

Padalia H, Moteriya P, Chanda S. Green synthesis of silver nanoparticles from marigold flower and its synergistic antimicrobial potential. Arab J Chem 2015;8:732-41.

Sadeghi B, Gholamhoseinpoor F. A study on the stability and green synthesis of silver nanoparticles using Ziziphora tenuior (Zt) extract at room temperature. Spectrochim Acta A Mol Biomol Spectrosc 2015;134:310-5.

Sridevi A, Sandhya A, Suvarnalatha Devi P. Characterization and antibacterial studies of leaf assisted silver nanoparticles from Carica papaya: A green synthetic approach. Int J Pharm Pharm Sci 2015;7:143-6.

Kalaiyarasu T, Karthi N, Gowri VS, Manju V. In vitro assessment of antioxidant and antibacterial activity of green synthesized silver nanoparticles from Digitaria radicosa leaves. Asian J Pharm Clin Res 2016;9:297-302.

Girish K. Antimicrobial activities of Lantana camara Linn. Asian J Pharm Clin Res 2017;10:57-67.

Gujral SS. Synthesis and characterization of Gold and Silver nano-particles using different leaf extracts namely Catharanthus roseus, Datura metel and Azadirachta indica and estimation of antimicrobial activity of silver nano-particles using disc diffusion method. Int J Drug Dev Res 2014;6:222-32.

Verma A, Mehata MS. Controllable synthesis of silver nanoparticles using Neem leaves and their antimicrobial activity. J Radiat Res Appl Sci 2016;9:109-15.

Girish K, Shankara Bhat. Neem-a green treasure. Electron J Biol 2008;4:102-11.

Shankar SS, Rai A, Ahmad A, Sastry M. Rapid synthesis of Au, Ag, and bimetallic Au core-Ag shell nanoparticles using neem (Azadirachta indica) leaf broth. J Colloid Interface Sci 2004;275:496-502.

Thirumurugan A, Jiflin GJ, Rajagomathi G, Tomy NA, Ramachandran S, Jaiganesh R. Biotechnological synthesis of gold nanoparticles of Azadirachta indica leaf extract. Int J Biol Technol 2010;1:75-7.

Bindhani BK, Panigrahi AK. Green synthesis of gold nanoparticles using neem (Azadirachta indica L.) leaf extract and its biomedical applications. Int J Adv Biotechnol Res 2014;5:457-64.

Pattanayak M, Nayak PL. Green synthesis and characterization of zero valent iron nanoparticles from the leaf extract of Azadirachta indica (neem). World J Nano Sci Technol 2013;2:6-9.

Rajendran K, Sen S. Effect of capping agent on antimicrobial activity of nanoparticles. Pharm Lett 2015;7:37-42.

Gnanasangeetha D, Sarala DT. Facile and eco-friendly method for the synthesis of zinc oxide nanoparticles using Azadirachta and Emblica. Int J Pharm Sci Res 2014;5:2866-73.

Oudhia A, Kulkarni P, Sharma S. Green synthesis of ZnO nanotubes for bioapplications. Int J Adv Eng Res Stud 2015;4:280-1.

Noorjahan CM, Jasmine Shahina SK, Deepika T, Rafiq S. Green synthesis and characterization of zinc oxide nanoparticles from neem (Azadirachta indicia). Int J Sci Eng Technol Res 2015;4:5751-3.

Krishnasamy A, Sundaresan M, Velan P. Rapid phytosynthesis of nano-sized titanium using leaf extract of Azadirachta indica. Intl J ChemTech Res 2015;8:2047-52.

Sankar R, Rizwana K, Shivashangari KS, Ravikumar V. Ultra-rapid photocatalytic activity of Azadirachta indica engineered colloidal titanium dioxide nanoparticles. Appl Nanosci 2015;5:731-36.

Larue C, Castillo-Michel H, Sobanska S, Cécillon L, Bureau S, Barthès V, et al. Foliar exposure of the crop Lactuca sativa to silver nanoparticles: Evidence for internalization and changes in ag speciation. J Hazard Mater 2014;264:98-106.

El-Chaghaby GA, Ahmad AF. Biosynthesis of silver nanoparticles using Pistacia lentiscus leaves extract and investigation of their antimicrobial effect. Oriental J Chem 2011;27:929-36.

Sharma S, Kumar S, Bulchandini BD, Taneja S, Banyal S. Green synthesis of silver nanoparticles and their antimicrobial activity against gram positive and gram negative bacteria. Int J Biotechnol Bioeng Res 2013;4:341-6.

Pourmortazavi SM, Taghdiri M, Makari V, Rahimi-Nasrabadi M. Procedure optimization for green synthesis of silver nanoparticles by aqueous extract of Eucalyptus oleosa. Spectrochim Acta A Mol Biomol Spectrosc 2015;136:1249-54.

Mittal J, Batra A, Singh A, Sharma MM. Phytofabrication of nanoparticles through plant as nanofactories. Adv Nat Sci Nanosci Nanotechnol 2014;5:043002.

Gao X, Yourick JJ, Topping VD, Black T, Olejnik N, Keltner Z, et al. Toxicogenomic study in rat thymus of F1 generation offspring following maternal exposure to silver ion. Toxicol Rep 2015;2:341-50.

Devi LS, Joshi SR. Ultrastructures of silver nanoparticles biosynthesized using endophytic fungi. J Microsc Ultrastruc 2015;3:29-37.

Richard JW, Spencer BA, McCoy LF, Carina E, Washington J, Edgar P. Acticoat versus silver ion: The truth. J Burns Surg Wound Care 2002;1:11-20.

Castellano JJ, Shafii SM, Ko F, Donate G, Wright TE, Mannari RJ, et al. Comparative evaluation of silver-containing antimicrobial dressings and drugs. Int Wound J 2007;4:114-22.

Prema P. Chemical mediated synthesis of silver nanoparticles and its potential antibacterial application. In: Carpi A, editor. Progress in Molecular and Environmental Bioengineering-From Analysis and Modeling to Technology Applications. 2011. Available from: http://www.InTechOpen.com/books.

Feng QL, Wu J, Chen GQ, Cui FZ, Kim TN, Kim JO, et al. A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. J Biomed Mater Res 2000;52:662-8.

Morones JR, Elechiguerra JL, Camacho A, Holt K, Kouri JB, Ramirez JT, et al. The bactericidal effect of silver nanoparticles. Nanotechnol 2005;16:2346-53.

Klueh U, Wagner V, Kelly S, Johnson A, Bryers JD. Efficacy of silver coated fabric to prevent bacterial colonization and subsequent device based biofilm formation. J Biomed Mater Res B Appl Biomater 2000;53:621-31.

Guggenbichler JP, Boswald M, Lugauer S, Krall T. A new technology of micro dispersed silver in polyurethane induces antimicrobial activity in central venous catheters. Infection 1999;27:16-23.

Danilczuk M, Lund A, Sadlo J, Yamada H, Michalik J. Conduction electron spin resonance of small silver particles. Spectrochim Acta A Mol Biomol Spectrosc 2006;63:189-91.

Kim JS, Kuk E, Yu KN, Kim JH, Park SJ, Lee HJ, et al. Antimicrobial effects of silver nanoparticles. Nanomed Nanotechnol Biol Med 2007;3:95-101.

Jeong SH, Yeo SY, Yi SC. The effect of filler particles size on the antibacterial properties of compounded polymer or silver fiber. J Mater Sci 2005;40:5407-11.

Gavhane AJ, Padmanabhan P, Kamble SP, Jangle SN. Synthesis of silver nanoparticles using extract of neem leaf and triphala and evaluation of their antimicrobial activities. Int J Pharm Bio Sci 2012;3:88-100.

Mathur A, Kushwaha A, Dalakoti V, Dalakoti G, Singh DS. Green synthesis of silver nanoparticles using medicinal plant and its characterization. Der Pharm Sin 2014;5:118-22.

Ahmed S, Ahmad M, Swami BL, Ikram S. Green synthesis of silver nanoparticles using Azadirachta indica aqueous leaf extract. J Radiat Res Appl Sci 2016;9:1-7.

Sajesh Kumar NK, Vazhacharickal PJ, Mathew JJ, Joy J. Synthesis of silver nano particles from neem leaf (Azadirachta indica) extract and its antibacterial activity. CIBTech J Biotechnol 2015;4:20-31.

Li Y, Leung P, Yao L, Song QW, Newton E. Antimicrobial effect of surgical masks coated with nanoparticles. J Hosp Infect 2006;62:58-63.

Tripathi A, Chandrasekaran N, Raichur AM, Mukherjee A. Antibacterial applications of silver nanoparticles synthesized by aqueous extract of Azadirachta indica (Neem) leaves. J Biomed Nanotechnol 2009;5:93-8.

Vijayameena C, Kavitha K. Studies and evaluation of phytosynthetic silver nanoparticles against UTI causing pathogens. Int J Curr Biotechnol 2013;1:22-4.

Lalitha A, Subbaiya R, Ponmurugan P. Synthesis of silver nanoparticles from leaf extract Azhadirachta indica and to study its anti-bacterial and antioxidant property. Int J Curr Microbiol App Sci 2013;2:228-35.

Shanthi D, Kalaimathi J. Plant-mediated synthesis of silver nanoparticles using neem leaf extracts and its antibacterial activity. Int J Inst Pharm Life Sci 2014;4:40-6.

Published

01-03-2018

How to Cite

K, G. “NEEM (AZADIRACHTA INDICA A. JUSS) AS A SOURCE FOR GREEN SYNTHESIS OF NANOPARTICLES”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 3, Mar. 2018, pp. 15-18, doi:10.22159/ajpcr.2018.v11i3.21939.

Issue

Section

Review Article(s)