FORMULATION AND EVALUATION OF MICONAZOLE NITRATE NANOEMULSION AND CREAM

  • Hetty Lendora Maha Department of Pharmaceutics, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
  • Kasmirul Ramlan Sinaga Department of Pharmaceutics, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
  • Kasmirul Ramlan Sinaga Department of Pharmaceutics, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
  • Masfria Masfria Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
  • Masfria Masfria Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

Abstract

 Objective: The present study is to determine the evaluation profile of the preparations nanoemulsion and cream of miconazole nitrate.

Methods: Preparation of nanoemulsi with concentrations 1%, 1.5%, and 2% using the principle of low-energy emulsification and miconazole nitrate cream was then performed physical evaluation of the preparation which included organoleptic test, pH measurement, viscosity test, emulsion type, cycling test, centrifugation test, particle size measurement with particle size analyzer, and homogeneity test of cream preparations.

Result: Based on organoleptic test, it can be seen that the miconazole nitrate nanoemulsion preparations produced are clear, colored weak yellow, and the cream is white. The average pH of the nanoemulsion preparations ranged from 6.01 to 6.25, while the cream preparations were 5.95–6.52. The average viscosity values of nanoemulsion preparations were 1707 cps, 1920 cps, and 1987 cps, respectively. In the cycling test, the nanoemulsion preparation remained weak yellow and odorless, and the cream preparation remained white and did not experience phase separation. In the centrifugation test, the nanoemulsion preparation and the cream were centrifuged at a rate of 3800 for 5 h, after centrifugation tests, both the nanoemulsing and cream preparations did not show any phase separation, in the nanoemulsion preparation possibly due to the high viscosity of the preparation. On the type nanoemulsi test, by dripping methylene blue on the formula. After observed, the blue methylene is evenly dispersed into the formula, indicating that all four formulas have an oil-in-water emulsion type (o/w). The particle size of the nanoemulsion preparation ranged from 102.36 nm to 309.11 nm.

Conclusion: The results of evaluation of miconazole nitrate nanoemulsion preparations were better than cream preparations.

Keywords: Nanoemulsion, Cream, Miconazole nitrate, Antifungal, Topical preparation.

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How to Cite
Maha, H. L., K. R. Sinaga, K. R. Sinaga, M. Masfria, and M. Masfria. “FORMULATION AND EVALUATION OF MICONAZOLE NITRATE NANOEMULSION AND CREAM”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 3, Mar. 2018, pp. 319-21, doi:10.22159/ajpcr.2018.v11i3.22056.
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Original Article(s)