EVALUATION OF BENZYLIDENE-ACETONE ANALOGUES OF CURCUMIN AS ANTITUBERCULOSIS


Cikra Ikhda Nur Hamidah Safitri, Ritmaleni Ritmaleni, Ning Rintiswati, Sardjiman Sardjiman, Takushi Kaneko

Abstract


 Objective: The objective of this research is to evaluate the effect of benzylideneacetone analog of curcumin against Mycobacterium tuberculosis (MTB) H37Rv.

Method: The activity of benzylideneacetone analog of curcumin is evaluated using mycobacteria growth indicator tube (MGIT) method and microplate alamar blue assay (MABA) method. The compound of minimum inhibitory concentration (MIC) is defined as the minimum concentration of drugs which really inhibit the growth of MTB.

Result: The MIC compound of 1,5-bis(3,4-dichlorophenyl)-1,4-pentadiene-3-one (C9) and 1,5-bis(3-chlorophenyl)-1,4-pentadiene-3-one (C10) can inhibit the bacteria of MTB at the concentration of 500 μg/ml using MGIT method. Based on MABA method, it can be obtained similar MIC value of C9 compound and C10 compound that are 187.5 μg/ml.

Conclusion: C9 and C10 have antituberculosis activity. Benzylideneacetone analog of curcumin which has chlor moiety has a better activity in inhibiting MTB, but it still needs further research to make it become a potent antituberculosis drug.


Keywords


Tuberculosis, Curcumin analog, Mycobacteria growth indicator tube, Microplate alamar blue assay.

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About this article

Title

EVALUATION OF BENZYLIDENE-ACETONE ANALOGUES OF CURCUMIN AS ANTITUBERCULOSIS

Topics

PHARMACY

Keywords

Tuberculosis, Curcumin analog, Mycobacteria growth indicator tube, Microplate alamar blue assay.

DOI

10.22159/ajpcr.2018.v11i4.22991

Date

01-04-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 4 April 2018 Page: 226-230

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

22 Views | 64 Downloads

Authors & Affiliations

Cikra Ikhda Nur Hamidah Safitri
Department of Pharmaceutical Chemistry, Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Indonesia.
Indonesia

Ritmaleni Ritmaleni
Department of Pharmaceutical Chemistry, Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Indonesia.
Indonesia

Ning Rintiswati
Department of Microbiology, , Faculty of Medicine Universitas Gadjah Mada, Yogyakarta, Indonesia.
Indonesia

Sardjiman Sardjiman
Department of Pharmaceutical Chemistry, Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Indonesia.
Indonesia

Takushi Kaneko
Tuberculosis Alliance, New York, United State.
United States


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