CHRONIC UNPREDICTABLE STRESS-INDUCED BEHAVIORAL AND ELECTROPHYSIOLOGICAL ALTERATIONS AND ITS AMELIORATIVE EFFECT BY MYRICETIN MICROEMULSION

  • Sakthivel G Department of Physiology, Dr. A.L.M Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai - 600 113, Tamil Nadu, India.
  • Deva Karunya M Department of Physiology, Dr. A.L.M Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai - 600 113, Tamil Nadu, India.
  • Prajisha P Department of Physiology, Dr. A.L.M Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai - 600 113, Tamil Nadu, India.
  • Keerthipriya Cs Department of Physiology, Dr. A.L.M Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai - 600 113, Tamil Nadu, India.
  • Ravindran R Department of Physiology, Dr. A.L.M Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai - 600 113, Tamil Nadu, India.

Abstract

 Objective: The present study is designed to investigate the effects of chronic unpredictable stress (CUS) on electrophysiological and behavioral alterations in male Wistar albino rats and its ameliorating effect by myricetin-microemulsion (MYR-ME).

Materials and Methods: Adult Wistar male albino rats were exposed to CUS for 21 days and treated with MYR-ME (10 mg/kg) for 21 days by oral administration. All the experimental animals were tested for anxiety and cognitive behavior by open-field behavior, light/dark test, eight-arm radial maze, spontaneous alteration T-maze, novel object recognition test, plasma corticosterone level, and electrophysiological activity.

Results: The rats which were exposed to CUS showed memory impairment, increased anxiety, decreased novel explorations, deleterious effect on decision-making, increased corticosterone level, increased brain wave frequency and amplitude, and also heart rate. Whereas, CUS with MYR-ME-treated group showed a protective effect against CUS-induced behavioral alterations, electrophysiological activity, and corticosterone levels, which is characterized by the enhancement of cognitive function, decreased anxiety and improved decision-making, novel exploration, decreased corticosterone, and electrophysiological activity.

Conclusion: From the present study, it is shown that MYR-ME may act as a potential anxiolytic and nootropic compound against CUS-induced alterations.

Keywords: Chronic unpredictable stress, Myricetin-microemulsion, Cognitive behavior, anxiety, Learning and memory, Electrophysiology.

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G, S., D. Karunya M, P. P, K. Cs, and R. R. “CHRONIC UNPREDICTABLE STRESS-INDUCED BEHAVIORAL AND ELECTROPHYSIOLOGICAL ALTERATIONS AND ITS AMELIORATIVE EFFECT BY MYRICETIN MICROEMULSION”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 3, Mar. 2018, pp. 124-31, doi:10.22159/ajpcr.2018.v11i3.23364.
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