• Harishkumar S Kuvempu University, Department of Pharmaceutical Chemistry, Post Graduate Centre, Kadur-577548
  • Satyanarayan Nd Kuvempu University, Department of Pharmaceutical Chemistry, Post Graduate Centre, Kadur-577548
  • Santhosha Sm Kuvempu University, Department of Pharmaceutical Chemistry, Post Graduate Centre, Kadur-577548


 Objective: Synthesis and antiproliferative study of novel 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinoline 7(a-j) derivatives.

Methods: 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinolines were synthesized by the addition of 4-(chloromethyl)-2-(thiophen-2-yl) quinoline (0.01 mol), piperidine (0.01 mol) in DMF (10 v) and K2CO3 (0.02 mol). The anticancer activity of the title compounds performed against T-47D, HeLa, HepG2, and MCF-7 human cancer cell lines growth was investigated by MTT assay.

Results: The compounds 7b and 7g exhibited 90% of the growth inhibitory effect on T-47D, HeLa, and MCF-7 and also 80% growth inhibition in HepG2 when compared with standard drug paclitaxel.

Conclusion: The synthesized compounds 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinoline 7(a-j) exhibited a considerable degree of growth inhibition of human cancer cell lines. The synthesized molecules 7(a-j) are in acceptable range and are less toxic and can be considered as possible hits for drug discovery.

Keywords: MTT assay, In silico, T-47D, HeLa, HepG2, MCF-7, Molinspiration.


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How to Cite
S, H., S. Nd, and S. Sm. “ANTIPROLIFERATIVE AND IN SILICO ADMET STUDY OF NEW 4-(PIPERIDIN-1-YLMETHYL)-2- (THIOPHEN-2-YL) QUINOLINE ANALOGUES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 4, Apr. 2018, pp. 306-13, doi:10.22159/ajpcr.2018.v11i4.24147.
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