HIGH SENSITIVE C-REACTIVE PROTEIN AND ITS RELATIONSHIP WITH OTHER CARDIOVASCULAR RISK VARIABLES IN OBESE, OVERWEIGHT AND HEALTHY INDIVIDUALS

  • Gayathri B Department of Biochemistry, SRM Medical College Hospital and Research Centre, Kattankulathur, SRM University, Kanchipuram - 603 203, Tamil Nadu, India.
  • Vinodhini Vm Department of Biochemistry, SRM Medical College Hospital and Research Centre, Kattankulathur, SRM University, Kanchipuram - 603 203, Tamil Nadu, India.

Abstract

Objective: More than 50% of the world's population is considered overweight and being overweight is associated with several comorbidities such as Type 2 diabetes mellitus, hypertension, cardiovascular diseases, dyslipidemia, respiratory diseases, osteoarthritis, and depression. Therefore, in this study, we have estimated the high sensitive C-reactive protein (hs-CRP) levels in obese, overweight, and normal body mass index (BMI) individuals and whether there was any relationship between hs-CRP and other risk factors of the cardiovascular system such as serum total cholesterol (TC) and other lipids.

Methods: A total of 150 participants, divided into three groups. Group I - 50 participants with normal BMI (18–22.99 kg/m2), Group II - 50 participants who were overweight (BMI = 23–24.99 kg/m2), and Group III - 50 who were obese (BMI ≥25 kg). We measured fasting plasma glucose, postprandial plasma glucose, serum TC, triacylglycerol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and hs-CRP.

Results: Obese individuals had increased hs-CRP compared with control (Group I) and overweight (Group II) groups. hs-CRP positively correlated with BMI and lipid profile.

Conclusion: Elevated hs-CRP was associated with cardiovascular risk factors in overweight and obese individuals. This high-risk group should be targeted for therapeutic lifestyle modifications to prevent further complications.

Keywords: Cardiovascular disease, High sensitive C-reactive protein, Obesity.

Author Biographies

Gayathri B, Department of Biochemistry, SRM Medical College Hospital and Research Centre, Kattankulathur, SRM University, Kanchipuram - 603 203, Tamil Nadu, India.
Assistant professor, Biochemistry
Vinodhini Vm, Department of Biochemistry, SRM Medical College Hospital and Research Centre, Kattankulathur, SRM University, Kanchipuram - 603 203, Tamil Nadu, India.
Professor, Biochemistry

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B, G., and V. Vm. “HIGH SENSITIVE C-REACTIVE PROTEIN AND ITS RELATIONSHIP WITH OTHER CARDIOVASCULAR RISK VARIABLES IN OBESE, OVERWEIGHT AND HEALTHY INDIVIDUALS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 8, Aug. 2018, pp. 194-8, doi:10.22159/ajpcr.2018.v11i8.26056.
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