FORMULATION AND EVALUATION OF ESOMEPRAZOLE FAST DISSOLVING BUCCAL FILMS
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i10.27321Keywords:
Fast dissolving buccal films, Esomeprazole, Polyvinyl alcohol, Polyvinylpyrrolidone, Polyethylene glycol 400 solvent evaporation methodAbstract
Objective: The present study deals with the formulation and evaluation of fast dissolving buccal films for effective treatment option in the gastroesophageal reflux disease.
Methods: Esomeprazole fast dissolving buccal films are a convenient formulation of which can be taken with or without water. In the present investigation, polyvinyl alcohol and polyvinylpyrrolidone were used as film-forming agents and polyethylene glycol 400 is taken as plasticizer. Solvent evaporation method was used for the preparation of fast dissolving buccal films.
Results: The films were prepared and evaluated for film thickness, folding endurance, dispersion test, drug content, and dissolution. The in vitro dissolution studies were carried out using simulated salivary fluid (pH 6.8 phosphate buffer).
Conclusion: Among all the formulations, Formulation E7 was released up to 99.6% of the drug from the film within 5 min of time which exhibits faster absorption and also shows desirable characteristics of the film. The drug-excipient interaction studies WERE carried out by Fourier-transform infrared studies, differential scanning calorimetry analysis-X-diffraction studies, and scanning electron microscopic studies and the results revealed that there were no major interactions between the drugs and excipients used for the preparation of films.
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References
Kendall MJ. Review article: Esomeprazole–the first proton pump inhibitor to be developed as an isomer. Aliment Pharmacol Ther 2003;17 Suppl 1:1-4.
Patel SR, Patel PR, Vora CN, Patel ND, Patel JK. Optimization and evaluation of delayed release tablets of rabeprazole sodium. Int J Pharmacy Pharm Sci 2011;2:144-56.
Chen CY, Lu CL, Luo JC, Chang FY, Lee SD, Lai YL, et al. Esomeprazole tablet vs omeprazole capsule in treating erosive esophagitis. World J Gastroenterol 2005;11:3112-7.
Miner P Jr. Katz PO, Chen Y, Sostek M. Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: A five-way crossover study. Am J Gastroenterol 2003;98:2616-20.
Edwards SJ, Lind T, Lundell L. Systematic review: Proton pump inhibitors (PPIs) for the healing of reflux oesophagitis-a comparison of esomeprazole with other PPIs. Aliment Pharmacol Ther 2006;24:743 50.
Moayyedi P, Talley NJ. Gastro-oesophageal reflux disease. Lancet 2006;367:2086-100.
Hatlebakk JG. Review article: Gastric acidity–comparison of esomeprazole with other proton pump inhibitors. Aliment Pharmacol Ther 2003;17 Suppl 1:10-5.
Narwal S, Saini V. Formulation, development and evaluation of fast disintegrating thin film of esomeprazole magnesium trihydrate. Am J Pharm Tech Res 2016;6:520-42.
Abouhussein DM, El-Bary AA, El Nabarawi SH. Chitosan mucoadhesive buccal films effect of different casting solvents on their physicochemical properties. Int J Pharm Pharm Sci 2016;8:206-13.
Yassina BG, Abassb HA. Design and evaluation of fast dissolving oro-dispersible films of metoclopramide hydrochloride using 32 multifactorial designs. Int J Pharm Pharm Sci 2016;8:218-22.
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