SARGASSUM POLYCYSTUM METHANOL EXTRACT AFFECTS THE NUCLEAR FACTOR-k BETA AND INTERLEUKIN-6 EXPRESSION IN STREPTOZOTOCIN-INDUCED DIABETES RATS

  • Muhamad Firdaus Department of Fish Product Technology, Faculty of Fisheries and Marine Sciences, Brawijaya University, Malang-65145, Indonesia.
  • Anies Chamidah Department of Fish Product Technology, Faculty of Fisheries and Marine Sciences, Brawijaya University, Malang-65145, Indonesia.

Abstract

Objective: The objective of this study is to investigate the attenuation of the nuclear factor-κ beta (NF-κB) and interleukin (IL)-6 expression in streptozotocin-induced diabetic rats by Sargassum polycystum methanol extract.

Methods: Diabetic rats were intraperitoneally induced by streptozotocin (40 mg/kg b.w.). S. polycystum methanol extract was administered to diabetic rats for 45 days. The effect of S. polycystum methanol extract on blood glucose, hemoglobin A1c (HbA1c), NF-κB, and IL-6 expression was investigated on streptozotocin-induced diabetic rats. The gliclazide (30 mg/kg b.w., p.o.) was used as a reference antidiabetic drug.

Results: The administration of S. polycystum methanol extract on streptozotocin-induced diabetic rats decreased the blood glucose level, HbA1c, NF-κB, and IL-6.

Conclusion: S. polycystum methanol extract indicates a promising anti-inflammation agent in diabetes.

Keywords: Diabetes mellitus, Free radical, Inflammation, Sargassum polycystum.

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Firdaus, M., and A. Chamidah. “SARGASSUM POLYCYSTUM METHANOL EXTRACT AFFECTS THE NUCLEAR FACTOR-K BETA AND INTERLEUKIN-6 EXPRESSION IN STREPTOZOTOCIN-INDUCED DIABETES RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 11, Nov. 2018, pp. 337-9, doi:10.22159/ajpcr.2018.v11i11.27658.
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